CANC additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| DAWN | Day One Biopharmaceuticals Inc | 2026-02-28 | Added / first present |
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| ARVN | Arvinas Inc | 2026-02-28 | Added / first present |
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| AVBP | ArriVent Biopharma Inc | 2026-02-28 | Added / first present |
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| CMPX | Compass Therapeutics Inc | 2026-02-28 | Added / first present |
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| ERAS | Erasca Inc | 2026-02-28 | Added / first present |
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| GLUE | Monte Rosa Therapeutics Inc | 2026-02-28 | Added / first present |
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| NTRA | Natera Inc | 2026-02-28 | Added / first present |
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| TYRA | Tyra Biosciences Inc | 2026-02-28 | Added / first present |
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| TERN | Terns Pharmaceuticals Inc | 2025-11-30 | Added / first present |
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| BBOT | BridgeBio Oncology Therapeutic | 2025-11-30 | Added / first present |
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| CRVS | Corvus Pharmaceuticals Inc | 2025-11-30 | Added / first present |
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| HALO | Halozyme Therapeutics Inc | 2025-11-30 | Added / first present |
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| JNJ | Johnson & Johnson | 2025-11-30 | Added / first present |
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| OLMA | Olema Pharmaceuticals Inc | 2025-11-30 | Added / first present |
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| ORIC | ORIC Pharmaceuticals Inc | 2025-11-30 | Added / first present |
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| PYXS | Pyxis Oncology Inc | 2025-11-30 | Added / first present |
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| XNCR | Xencor Inc | 2025-11-30 | Added / first present |
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| AAPG | Ascentage Pharma Group Interna | 2025-08-31 | Added / first present |
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| HCM | HUTCHMED China Ltd | 2025-08-31 | Added / first present |
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| IOVA | Iovance Biotherapeutics Inc | 2025-08-31 | Added / first present |
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| NUVB | Nuvation Bio Inc | 2025-08-31 | Added / first present |
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| URGN | UroGen Pharma Ltd | 2025-08-31 | Added / first present |
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| ANAB | AnaptysBio Inc | 2025-05-31 | Added / first present |
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| ELVN | Enliven Therapeutics Inc | 2025-05-31 | Added / first present |
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| IMNM | Immunome Inc | 2025-05-31 | Added / first present |
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| RHHBY | Roche Holding AG | 2025-02-28 | Added / first present |
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| ABBV | AbbVie Inc | 2025-02-28 | Added / first present |
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| AUTL | Autolus Therapeutics PLC | 2025-02-28 | Added / first present |
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| BBIO | Bridgebio Pharma Inc | 2025-02-28 | Added / first present |
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| BMY | Bristol-Myers Squibb Co | 2025-02-28 | Added / first present |
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| CELC | Celcuity Inc | 2025-02-28 | Added / first present |
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| IOVA | Iovance Biotherapeutics Inc | 2025-02-28 | Added / first present |
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| LLY | Eli Lilly & Co | 2025-02-28 | Added / first present |
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| ONC | BeiGene Ltd | 2025-02-28 | Added / first present |
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| REPL | Replimune Group Inc | 2025-02-28 | Added / first present |
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| SMMT | Summit Therapeutics Inc | 2025-02-28 | Added / first present |
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| SNDX | Syndax Pharmaceuticals Inc | 2025-02-28 | Added / first present |
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| ZLAB | Zai Lab Ltd | 2025-02-28 | Added / first present |
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| ZYME | Zymeworks Inc | 2025-02-28 | Added / first present |
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| BNTX | BioNTech SE | 2024-11-30 | Added / first present |
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| NRIX | Nurix Therapeutics Inc | 2024-11-30 | Added / first present |
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| ORIC | ORIC Pharmaceuticals Inc | 2024-11-30 | Added / first present |
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| TERN | Terns Pharmaceuticals Inc | 2024-08-31 | Added / first present |
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| BCYC | Bicycle Therapeutics PLC | 2024-08-31 | Added / first present |
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| CGON | CG oncology Inc | 2024-08-31 | Added / first present |
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| CRBP | Corbus Pharmaceuticals Holding | 2024-08-31 | Added / first present |
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| JANX | Janux Therapeutics Inc | 2024-08-31 | Added / first present |
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| JSPR | Jasper Therapeutics Inc | 2024-08-31 | Added / first present |
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| MRSN | Mersana Therapeutics Inc | 2024-05-31 | Added / first present |
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| AMGN | Amgen Inc | 2024-05-31 | Added / first present |
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| IDYA | Ideaya Biosciences Inc | 2024-05-31 | Added / first present |
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Removals
| Ticker | Issuer | Observed date | Change |
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| BBOT | BridgeBio Oncology Therapeutic | 2026-02-28 | Removed / first absent |
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| PYXS | Pyxis Oncology Inc | 2026-02-28 | Removed / first absent |
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| AAPG | Ascentage Pharma Group Interna | 2026-02-28 | Removed / first absent |
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| IOVA | Iovance Biotherapeutics Inc | 2025-11-30 | Removed / first absent |
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| ELVN | Enliven Therapeutics Inc | 2026-02-28 | Removed / first absent |
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| AUTL | Autolus Therapeutics PLC | 2025-11-30 | Removed / first absent |
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| IOVA | Iovance Biotherapeutics Inc | 2025-05-31 | Removed / first absent |
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| REPL | Replimune Group Inc | 2026-02-28 | Removed / first absent |
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| BNTX | BioNTech SE | 2025-02-28 | Removed / first absent |
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| ORIC | ORIC Pharmaceuticals Inc | 2025-05-31 | Removed / first absent |
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| TERN | Terns Pharmaceuticals Inc | 2025-02-28 | Removed / first absent |
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| BCYC | Bicycle Therapeutics PLC | 2025-02-28 | Removed / first absent |
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| CRBP | Corbus Pharmaceuticals Holding | 2025-02-28 | Removed / first absent |
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| JSPR | Jasper Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| MRSN | Mersana Therapeutics Inc | 2024-08-31 | Removed / first absent |
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| DCPH | Deciphera Pharmaceuticals Inc | 2024-08-31 | Removed / first absent |
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| BGNE | BeiGene Ltd | 2025-02-28 | Removed / first absent |
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| BPMC | Blueprint Medicines Corp | 2025-08-31 | Removed / first absent |
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| EXAS | Exact Sciences Corp | 2025-05-31 | Removed / first absent |
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| SHL | Siemens Healthineers AG | 2025-02-28 | Removed / first absent |
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| 4568 | Daiichi Sankyo Co Ltd | 2026-02-28 | Removed / first absent |
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| SWTX | SpringWorks Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| MOR | MorphoSys AG | 2024-05-31 | Removed / first absent |
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| FUSN | Fusion Pharmaceuticals Inc | 2024-05-31 | Removed / first absent |
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| MRUS | Merus NV | 2025-11-30 | Removed / first absent |
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| DAWN | Day One Biopharmaceuticals Inc | 2025-11-30 | Removed / first absent |
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| AGIO | Agios Pharmaceuticals Inc | 2025-05-31 | Removed / first absent |
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| ARVN | Arvinas Inc | 2025-11-30 | Removed / first absent |
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| BMY | Bristol-Myers Squibb Co | 2024-08-31 | Removed / first absent |
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| CLDX | Celldex Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| CRSP | CRISPR Therapeutics AG | 2025-02-28 | Removed / first absent |
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| FATE | Fate Therapeutics Inc | 2024-11-30 | Removed / first absent |
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| ILMN | Illumina Inc | 2025-11-30 | Removed / first absent |
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| INCY | Incyte Corp | 2025-08-31 | Removed / first absent |
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| LNTH | Lantheus Holdings Inc | 2025-08-31 | Removed / first absent |
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| MREO | Mereo Biopharma Group PLC | 2025-08-31 | Removed / first absent |
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| MRNA | Moderna Inc | 2025-02-28 | Removed / first absent |
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| NTLA | Intellia Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| OPCH | Option Care Health Inc | 2024-08-31 | Removed / first absent |
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| PYXS | Pyxis Oncology Inc | 2024-08-31 | Removed / first absent |
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| SDGR | Schrodinger Inc/United States | 2026-02-28 | Removed / first absent |
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| TXG | 10X Genomics Inc | 2024-08-31 | Removed / first absent |
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