Return on investment (ROI), also called return on invested capital, is the profit a company earns for every dollar of long-term capital from both lenders and shareholders, shown as a percentage. It is net income divided by long-term debt plus shareholder equity, and the table shows both amounts. Because debt is included in the base, ROI does not rise just because a company replaces equity with borrowing, which sets it apart from ROE. Quarterly points divide the trailing four quarters of net income by the balance at that quarter end; annual points divide the filed fiscal-year net income by the fiscal-year-end balance.
IONIS PHARMACEUTICALS INC roi for fiscal 2025 was -16.96%, a change of 8.39% from fiscal 2024.
IONIS PHARMACEUTICALS INC roi for fiscal 2024 was -25.34%, a change of -2.84% from fiscal 2023.
IONIS PHARMACEUTICALS INC roi for fiscal 2023 was -22.50%, a change of -7.08% from fiscal 2022.
IONIS PHARMACEUTICALS INC roi for fiscal 2022 was -15.42%.