| 2026-05-07 | 10-Q | 10.1 | Third Amended and Restated Non-Employee Director Compensation Policy |
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| 2026-04-16 | 8-K | 10.1 | Employment Agreement, effective as of April 16, 2026, by and between Prime Medicine, Inc. and Svetlana Makhni |
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| 2025-11-07 | 10-Q | 10.3 | Side Letter No. 2 to License Agreement, dated September 11, 2025, between The Broad Institute, Inc. and the Registrant |
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| 2025-11-07 | 10-Q | 10.2 | Amendment No. 5 to License Agreement, dated September 11, 2025, between The Broad Institute, Inc. and the Registrant |
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| 2025-11-07 | 10-Q | 10.1 | Amendment No. 4 to License Agreement, dated September 11, 2025, between The Broad Institute, Inc. and the Registrant |
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| 2025-08-07 | 10-Q | 10.6 | Consulting Agreement, dated July 15, 2025, between the Registrant and Jeremy Duffield |
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| 2025-08-07 | 10-Q | 10.5 | Separation Agreement, dated July 17, 2025, between the Registrant and Jeremy Duffield |
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| 2025-08-07 | 10-Q | 10.4 | Amended and Restated Employment Agreement, effective May 19, 2025, between the Registrant and Allan Reine |
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| 2025-08-07 | 10-Q | 10.3 | Consulting Agreement, dated May 18, 2025, between the Registrant and KMG Strategic Consulting LLC |
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| 2025-08-07 | 10-Q | 10.2 | Separation Agreement, dated May 18, 2025, between the Registrant and Keith Gottesdiener |
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| 2025-08-07 | 10-Q | 10.1 | Second Amended and Restated Non-Employee Director Compensation Policy |
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| 2024-11-12 | 10-Q | 10.3 | Amendment No. 4 to License Agreement, dated September 27, 2024, by and between the Broad Institute, Inc. and the Registrant. |
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| 2024-11-12 | 10-Q | 10.2 | Research Collaboration and License Agreement, dated September 28, 2024, by and between Juno Therapeutics, Inc. and the Registrant. |
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| 2024-11-12 | 10-Q | 10.1 | Securities Purchase Agreement, dated September 28, 2024, by and between Juno Therapeutics, Inc. and the Registrant. |
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| 2024-08-08 | 10-Q | 10.1 | Amended and Restated Non-Employee Director Compensation Policy |
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| 2024-03-01 | 10-K | 10.22 | Amendment No. 12 to License Agreement, dated October 2, 2023, between MIL 21E, LLC and the Registrant |
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| 2024-01-05 | 8-K | 10.1 | Employment Agreement, effective as of January 17, 2024. |
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| 2023-11-03 | 10-Q | 10.1 | Amendment No. 1 to the Amended and Restated Employment Agreement, dated July 6, 2023, between the Registrant and Keith Gottesdiener. |
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| 2023-08-07 | 10-Q | 10.5 | Eleventh Amendment to License Agreement, dated May 4, 2023, between Prime Medicine, Inc. and MIL 21E, LLC |
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| 2023-08-07 | 10-Q | 10.4 | Tenth Amendment to License Agreement, dated April 14, 2023, between Prime Medicine, Inc. and MIL 21E, LLC |
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| 2023-08-07 | 10-Q | 10.3 | Ninth Amendment to License Agreement, dated March 17, 2023, between Prime Medicine, Inc. and MIL 21E, LLC |
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| 2023-08-07 | 10-Q | 10.2 | Sixth Amendment to License Agreement, dated April 5, 2022, between Prime Medicine, Inc. and MIL 21E, LLC |
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| 2023-08-07 | 10-Q | 10.1 | Lease Agreement, dated as of November 22, 2021, between NW Cambridge Property Owner, LLC and the Registrant |
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| 2023-03-09 | 10-K | 10.18 | License Agreement, dated December 22, 2022, between The Broad Institute, Inc. and the Registrant |
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| 2023-03-09 | 10-K | 10.17 | Amendment No. 3 to License Agreement, dated December 22, 2022, between The Broad Institute, Inc. and the Registrant |
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