ACCELERON PHARMA INC. Forms 3, 4 and 5: Stock Options
Statements of beneficial ownership filed with the SEC by officers, directors and 10% owners: 118 rows in 2015. Transaction codes are the SEC's. Shares and prices are split-adjusted; the as-filed figure is underneath.
- 2015-12-22: Reporting owner MCLAUGHLIN KEVIN F; Form 4; Security Option to Purchase Common Stock; Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
- 2015-10-19: Reporting owner Kumar Ravindra; Form 4; Security Option to Purchase Common Stock; Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
- 2015-10-19: Reporting owner Kumar Ravindra; Form 4; Security Option to Purchase Common Stock; Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
- 2015-10-19: Reporting owner Kumar Ravindra; Form 4; Security Option to Purchase Common Stock; Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
| Transaction date | Reporting owner | Form | Security | Transaction | Shares | Price | Price that day | Filing |
|---|---|---|---|---|---|---|---|---|
| 2015-12-22 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −7,500 21,251 owned after | $3.88 exercise price | 2015-12-23 | |
| 2015-10-19 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,300 0 owned after | $1.80 exercise price | 2015-10-21 | |
| 2015-10-19 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −6,250 0 owned after | $5.08 exercise price | 2015-10-21 | |
| 2015-10-19 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,516 10,984 owned after | $5.28 exercise price | 2015-10-21 | |
| 2015-10-07 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −7,000 28,751 owned after | $3.88 exercise price | 2015-10-09 | |
| 2015-10-07 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −19,000 202,133 owned after | $5.08 exercise price | 2015-10-09 | |
| 2015-09-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 32,307 owned after | $5.28 exercise price | 2015-09-16 | |
| 2015-09-15 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −11,485 13,515 owned after | $3.88 exercise price | 2015-09-16 | |
| 2015-09-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,500 22,000 owned after | $3.88 exercise price | 2015-09-16 | |
| 2015-09-14 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −8,500 0 owned after | $0.40 exercise price | 2015-09-15 | |
| 2015-09-08 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 37,251 owned after | $3.88 exercise price | 2015-09-10 | |
| 2015-09-08 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 35,751 owned after | $3.88 exercise price | 2015-09-10 | |
| 2015-09-08 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −19,000 221,133 owned after | $5.08 exercise price | 2015-09-10 | |
| 2015-08-24 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −20,000 3,500 owned after | $3.88 exercise price | 2015-08-25 | |
| 2015-08-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 0 owned after | $0.48 exercise price | 2015-08-19 | |
| 2015-08-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,600 19,896 owned after | $5.08 exercise price | 2015-08-19 | |
| 2015-08-17 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 34,307 owned after | $5.28 exercise price | 2015-08-19 | |
| 2015-08-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,461 0 owned after | $5.88 exercise price | 2015-08-17 | |
| 2015-08-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,039 27,500 owned after | $3.88 exercise price | 2015-08-17 | |
| 2015-08-10 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 43,751 owned after | $3.88 exercise price | 2015-08-12 | |
| 2015-08-10 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 42,251 owned after | $3.88 exercise price | 2015-08-12 | |
| 2015-08-10 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −19,000 240,133 owned after | $5.08 exercise price | 2015-08-12 | |
| 2015-07-30 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 8,500 owned after | $0.40 exercise price | 2015-08-03 | |
| 2015-07-30 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −7,527 2,346 owned after | $5.28 exercise price | 2015-08-03 | |
| 2015-07-30 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,895 6,250 owned after | $5.28 exercise price | 2015-08-03 | |
| 2015-07-28 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 48,751 owned after | $3.88 exercise price | 2015-07-30 | |
| 2015-07-20 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 4,000 owned after | $0.48 exercise price | 2015-07-21 | |
| 2015-07-20 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −800 21,496 owned after | $5.08 exercise price | 2015-07-21 | |
| 2015-07-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −807 23,693 owned after | $3.88 exercise price | 2015-07-17 | |
| 2015-07-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,193 36,307 owned after | $5.28 exercise price | 2015-07-17 | |
| 2015-07-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,500 4,461 owned after | $5.88 exercise price | 2015-07-16 | |
| 2015-07-07 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 55,751 owned after | $3.88 exercise price | 2015-07-09 | |
| 2015-07-07 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 53,751 owned after | $3.88 exercise price | 2015-07-09 | |
| 2015-07-07 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −15,633 27,867 owned after | $3.88 exercise price | 2015-07-09 | |
| 2015-07-07 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −3,367 259,133 owned after | $5.08 exercise price | 2015-07-09 | |
| 2015-06-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 8,000 owned after | $0.48 exercise price | 2015-06-19 | |
| 2015-06-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,600 22,296 owned after | $5.08 exercise price | 2015-06-19 | |
| 2015-06-17 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −7,701 28,539 owned after | $3.88 exercise price | 2015-06-18 | |
| 2015-06-15 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,500 9,961 owned after | $5.88 exercise price | 2015-06-16 | |
| 2015-06-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 24,500 owned after | $3.88 exercise price | 2015-06-16 | |
| 2015-06-10 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 60,751 owned after | $3.88 exercise price | 2015-06-10 | |
| 2015-06-08 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 67,251 owned after | $3.88 exercise price | 2015-06-09 | |
| 2015-06-08 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 65,751 owned after | $3.88 exercise price | 2015-06-09 | |
| 2015-06-08 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −19,000 43,500 owned after | $3.88 exercise price | 2015-06-09 | |
| 2015-05-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 12,000 owned after | $0.48 exercise price | 2015-05-19 | |
| 2015-05-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,600 23,896 owned after | $5.08 exercise price | 2015-05-19 | |
| 2015-05-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 26,500 owned after | $3.88 exercise price | 2015-05-18 | |
| 2015-05-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,500 15,461 owned after | $5.88 exercise price | 2015-05-18 | |
| 2015-05-11 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −6,500 77,251 owned after | $3.88 exercise price | 2015-05-13 | |
| 2015-05-11 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 72,251 owned after | $3.88 exercise price | 2015-05-13 | |
| 2015-05-11 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −20,000 62,500 owned after | $3.88 exercise price | 2015-05-13 | |
| 2015-05-11 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 95,000 owned after | $1.80 exercise price | 2015-05-13 | |
| 2015-05-08 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 28,500 owned after | $3.88 exercise price | 2015-05-11 | |
| 2015-04-28 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 2,300 owned after | $1.80 exercise price | 2015-04-30 | |
| 2015-04-20 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 16,000 owned after | $0.48 exercise price | 2015-04-21 | |
| 2015-04-16 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −12,000 23,500 owned after | $3.88 exercise price | 2015-04-17 | |
| 2015-04-15 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 33,500 owned after | $3.88 exercise price | 2015-04-17 | |
| 2015-04-07 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 88,751 owned after | $3.88 exercise price | 2015-04-08 | |
| 2015-04-07 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 83,751 owned after | $3.88 exercise price | 2015-04-08 | |
| 2015-04-07 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 82,500 owned after | $3.88 exercise price | 2015-04-08 | |
| 2015-04-06 | Nader Francois Director | 4 | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $34.14 exercise price | 2015-04-08 | |
| 2015-03-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 20,000 owned after | $0.48 exercise price | 2015-03-20 | |
| 2015-03-18 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −800 25,496 owned after | $5.08 exercise price | 2015-03-20 | |
| 2015-03-16 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,461 0 owned after | $5.88 exercise price | 2015-03-17 | |
| 2015-03-16 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,039 20,961 owned after | $5.88 exercise price | 2015-03-17 | |
| 2015-03-13 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 0 owned after | $5.08 exercise price | 2015-03-17 | |
| 2015-03-09 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 92,251 owned after | $3.88 exercise price | 2015-03-10 | |
| 2015-03-09 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 90,751 owned after | $3.88 exercise price | 2015-03-10 | |
| 2015-03-04 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 0 owned after | $1.80 exercise price | 2015-03-06 | |
| 2015-03-04 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 4,000 owned after | $5.08 exercise price | 2015-03-06 | |
| 2015-03-04 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,500 1,461 owned after | $5.88 exercise price | 2015-03-06 | |
| 2015-03-04 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −500 0 owned after | $5.88 exercise price | 2015-03-06 | |
| 2015-03-04 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −3,500 0 owned after | $5.88 exercise price | 2015-03-06 | |
| 2015-03-04 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 24,000 owned after | $0.48 exercise price | 2015-03-06 | |
| 2015-03-04 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,600 26,296 owned after | $5.08 exercise price | 2015-03-06 | |
| 2015-03-04 | Sherman Matthew L Officer (EVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +15,000 15,000 owned after | $41.01 exercise price | 2015-03-06 | |
| 2015-03-04 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,094 0 owned after | $1.80 exercise price | 2015-03-06 | |
| 2015-03-04 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −3,906 2,344 owned after | $5.08 exercise price | 2015-03-06 | |
| 2015-03-04 | Ertel Steven D Officer (EVP & Chief Operating Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +30,000 30,000 owned after | $41.01 exercise price | 2015-03-06 | |
| 2015-02-09 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 98,751 owned after | $3.88 exercise price | 2015-02-11 | |
| 2015-02-09 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 97,251 owned after | $3.88 exercise price | 2015-02-11 | |
| 2015-02-02 | Ertel Steven D Officer (SVP & Chief Business Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −5,000 1,094 owned after | $1.80 exercise price | 2015-02-04 | |
| 2015-02-02 | Kumar Ravindra Officer (VP & Chief Scientific Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 500 owned after | $5.88 exercise price | 2015-02-04 | |
| 2015-01-21 | Knopf John L Director, Officer (CEO and President) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −12,500 0 owned after | $0.40 exercise price | 2015-01-22 | |
| 2015-01-20 | Sherman Matthew L Officer (SVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,600 27,896 owned after | $5.08 exercise price | 2015-01-22 | |
| 2015-01-20 | Sherman Matthew L Officer (SVP & Chief Medical Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −4,000 28,000 owned after | $0.48 exercise price | 2015-01-22 | |
| 2015-01-15 | Ertel Steven D Officer (SVP & Chief Business Officer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 35,500 owned after | $3.88 exercise price | 2015-01-16 | |
| 2015-01-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −3,500 0 owned after | $0.92 exercise price | 2015-01-16 | |
| 2015-01-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −500 2,000 owned after | $1.80 exercise price | 2015-01-16 | |
| 2015-01-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,562 12,145 owned after | $5.28 exercise price | 2015-01-16 | |
| 2015-01-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −1,500 6,000 owned after | $5.08 exercise price | 2015-01-16 | |
| 2015-01-14 | Quisel John D Officer (SVP Gen. Counsel & Secretary) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,438 6,961 owned after | $5.88 exercise price | 2015-01-16 | |
| 2015-01-12 | MCLAUGHLIN KEVIN F Officer (SVP, CFO and Treasurer) | 4 | Option to Purchase Common Stock Derivative · Direct | M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | −2,000 103,751 owned after | $3.88 exercise price | 2015-01-13 | |
| 2015-01-08 | Kearney Terrence C Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +4,665 4,665 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | Nader Francois Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +576 576 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | POPS RICHARD F Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | Zakrzewski Joseph S Director | 4/A | Option to purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | Maniatis Tom Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | George Jean Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $41.20 exercise price | 2015-04-08 | |
| 2015-01-08 | MCGUIRE TERRANCE Director | 4/A | Option to Purchase Common Stock Derivative · Direct | A Grant, award or other acquisition pursuant to Rule 16b-3(d) | +10,000 10,000 owned after | $41.20 exercise price | 2015-04-08 |