HRTS additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| GUBRA | Gubra A/S | 2026-02-28 | Added / first present |
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| ISRG | Intuitive Surgical Inc | 2025-11-30 | Added / first present |
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| JNJ | Johnson & Johnson | 2025-11-30 | Added / first present |
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| MLYS | Mineralys Therapeutics Inc | 2025-11-30 | Added / first present |
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| QURE | uniQure NV | 2025-11-30 | Added / first present |
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| TEVA | Teva Pharmaceutical Industries | 2025-11-30 | Added / first present |
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| NBIX | Neurocrine Biosciences Inc | 2025-08-31 | Added / first present |
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| RNA | Avidity Biosciences Inc | 2025-08-31 | Added / first present |
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| RVMD | Revolution Medicines Inc | 2025-08-31 | Added / first present |
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| MTSR | Metsera Inc | 2025-05-31 | Added / first present |
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| SRRK | Scholar Rock Holding Corp | 2025-05-31 | Added / first present |
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| RHHBY | Roche Holding AG | 2025-02-28 | Added / first present |
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| ABBV | AbbVie Inc | 2025-02-28 | Added / first present |
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| ABT | Abbott Laboratories | 2025-02-28 | Added / first present |
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| BMY | Bristol-Myers Squibb Co | 2025-02-28 | Added / first present |
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| DHR | Danaher Corp | 2025-02-28 | Added / first present |
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| GILD | Gilead Sciences Inc | 2025-02-28 | Added / first present |
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| INSM | Insmed Inc | 2025-02-28 | Added / first present |
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| MCK | McKesson Corp | 2025-02-28 | Added / first present |
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| MRK | Merck & Co Inc | 2025-02-28 | Added / first present |
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| TMO | Thermo Fisher Scientific Inc | 2025-02-28 | Added / first present |
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| UNH | UnitedHealth Group Inc | 2025-02-28 | Added / first present |
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| GPCR | Structure Therapeutics Inc | 2024-11-30 | Added / first present |
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| RANI | Rani Therapeutics Holdings Inc | 2024-11-30 | Added / first present |
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| REGN | Regeneron Pharmaceuticals Inc | 2024-11-30 | Added / first present |
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| TERN | Terns Pharmaceuticals Inc | 2024-08-31 | Added / first present |
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| GUBRA | Gubra A/S | 2024-08-31 | Added / first present |
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| AZN | AstraZeneca PLC | 2024-08-31 | Added / first present |
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| CRBP | Corbus Pharmaceuticals Holding | 2024-08-31 | Added / first present |
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| EWTX | Edgewise Therapeutics Inc | 2024-08-31 | Added / first present |
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| SLNO | Soleno Therapeutics Inc | 2024-05-31 | Added / first present |
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| SKYE | Skye Bioscience Inc | 2024-05-31 | Added / first present |
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| SLN | Silence Therapeutics PLC | 2024-05-31 | Added / first present |
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Removals
| Ticker | Issuer | Observed date | Change |
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| MLYS | Mineralys Therapeutics Inc | 2026-02-28 | Removed / first absent |
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| QURE | uniQure NV | 2026-02-28 | Removed / first absent |
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| RNA | Avidity Biosciences Inc | 2025-11-30 | Removed / first absent |
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| MTSR | Metsera Inc | 2025-08-31 | Removed / first absent |
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| GPCR | Structure Therapeutics Inc | 2025-11-30 | Removed / first absent |
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| RANI | Rani Therapeutics Holdings Inc | 2025-02-28 | Removed / first absent |
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| TERN | Terns Pharmaceuticals Inc | 2025-02-28 | Removed / first absent |
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| GUBRA | Gubra A/S | 2025-08-31 | Removed / first absent |
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| CRBP | Corbus Pharmaceuticals Holding | 2025-02-28 | Removed / first absent |
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| EWTX | Edgewise Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| SLNO | Soleno Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| SKYE | Skye Bioscience Inc | 2024-11-30 | Removed / first absent |
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| SLN | Silence Therapeutics PLC | 2025-02-28 | Removed / first absent |
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| CBAY | Cymabay Therapeutics Inc | 2024-05-31 | Removed / first absent |
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| BAYN | Bayer AG | 2024-05-31 | Removed / first absent |
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| AKRO | Akero Therapeutics Inc | 2025-11-30 | Removed / first absent |
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| SWAV | Shockwave Medical Inc | 2024-05-31 | Removed / first absent |
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| NARI | Inari Medical Inc | 2025-02-28 | Removed / first absent |
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| VERV | Verve Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| ARCT | Arcturus Therapeutics Holdings | 2024-11-30 | Removed / first absent |
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| BMY | Bristol-Myers Squibb Co | 2024-08-31 | Removed / first absent |
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| GPCR | Structure Therapeutics Inc | 2024-08-31 | Removed / first absent |
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| KROS | Keros Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| MIRM | Mirum Pharmaceuticals Inc | 2025-11-30 | Removed / first absent |
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| MLYS | Mineralys Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| MREO | Mereo Biopharma Group PLC | 2025-08-31 | Removed / first absent |
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| OMCL | Omnicell Inc | 2024-08-31 | Removed / first absent |
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| OSCR | Oscar Health Inc | 2024-11-30 | Removed / first absent |
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| RARE | Ultragenyx Pharmaceutical Inc | 2025-02-28 | Removed / first absent |
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| RCKT | Rocket Pharmaceuticals Inc | 2025-08-31 | Removed / first absent |
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| TNYA | Tenaya Therapeutics Inc | 2025-02-28 | Removed / first absent |
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| WST | West Pharmaceutical Services I | 2025-11-30 | Removed / first absent |
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