| 2026-07-21 | 8-K | 10.2 | Form of Amendment No. 1 to Preferred Stock Purchase Agreement. |
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| 2026-03-31 | 8-K | 10.4 | Registration Rights Agreement, dated March 27, 2026, by and between SmartKem, Inc. and the investor signatory thereto |
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| 2026-03-31 | 8-K | 10.3 | Common Stock Purchase Agreement, dated March 27, 2026, by and between SmartKem, Inc. and the investor signatory thereto |
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| 2026-03-31 | 8-K | 10.2 | Form of Preferred Stock Registration Rights Agreement |
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| 2026-03-31 | 8-K | 10.1 | Form of Preferred Stock Purchase Agreement |
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| 2026-03-26 | 8-K | 10.1 | Form of Securities Purchase Agreement |
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| 2026-03-19 | 8-K | 10.8 | Form of Waiver and Termination Agreement |
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| 2026-03-19 | 8-K | 10.7 | Form of Intellectual Property Assignment Agreement |
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| 2026-03-19 | 8-K | 10.6 | Form of Settlement Agreement and Release |
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| 2026-03-19 | 8-K | 10.5 | Form of Intellectual Property Security Agreement |
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| 2026-03-19 | 8-K | 10.4 | Form of Guaranty |
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| 2026-03-19 | 8-K | 10.3 | Form of Security and Pledge Agreement |
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| 2026-03-19 | 8-K | 10.2 | Form of Senior Secured Promissory Note |
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| 2026-03-19 | 8-K | 10.1 | Form of Securities Purchase Agreement |
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| 2026-02-06 | 8-K | 10.1 | Form of Debt Conversion Agreement |
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| 2026-01-30 | 8-K | 10.1 | Form of Securities Purchase Agreement |
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| 2025-11-03 | 8-K | 10.3 | Security Agreement, dated October 31, 2025, by and between SmartKem, Inc. and The Hewlett Fund LP, as collateral agent |
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| 2025-11-03 | 8-K | 10.2 | Form of Senior Secured Noted |
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| 2025-11-03 | 8-K | 10.1 | Form of Securities Purchase Agreement |
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| 2025-10-14 | 8-K | 10.1 | Amendment Agreement, dated October 13, 2025 |
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| 2025-09-05 | 8-K | 10.1 | Amendment No. 1 to Employment Agreement, dated September 3, 2025, by and between SmartKem, Inc. and Ian Jenks. |
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| 2025-08-12 | 10-Q | 10.4 | Lease of The Whole of the 8th Floor, Hexagon Tower, Manchester, M9 8GP, dated May 22, 2025, between AG Hexagon BV and SmartKem Limited |
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| 2025-06-24 | 8-K | 10.1 | Letter of Variation, dated June 19, 2025, by and between SmartKem Limited and CPI Innovation Services Limited. |
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| 2025-06-04 | 8-K | 10.1 | Letter of Variation, dated June 1, 2025, by and between SmartKem Limited and CPI Innovation Services Limited. |
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| 2025-05-28 | 8-K | 10.1 | Amendment to the 2021 Equity Incentive Plan. |
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| 2025-03-31 | 10-K | 10.32 | License of Office Space, dated March 28, 2025, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2025-03-31 | 10-K | 10.31 | Letter of Variation, dated March 28, 2025, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2025-03-10 | 8-K | 10.1 | Employment Agreement, dated as of March 10, 2025, by and between the SmartKem Limited and Jonathan Watkins |
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| 2024-12-20 | 8-K | 10.3 | Form of Registration Rights Agreement, dated December 18, 2024 among the Company and the parties thereto |
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| 2024-12-20 | 8-K | 10.2 | Form of Securities Purchase Agreement, dated December 18, 2024 among the Company and the PIPE Investors party thereto |
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| 2024-12-20 | 8-K | 10.1 | Form of Securities Purchase Agreement, dated December 18, 2024 among the Company and the RD Purchasers party thereto |
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| 2024-12-18 | 8-K | 10.2 | General Release dated December 17, 2024 |
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| 2024-12-18 | 8-K | 10.1 | Consent and Amendment Agreement dated December 17, 2024 |
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| 2024-12-12 | 8-K | 10.1 | Consent Agreement, dated December 11, 2024, between the Company and the Consenting Holders |
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| 2024-12-05 | 8-K | 10.1 | Collaboration Agreement, dated December 2, 2024, by and between SmartKem Limited and FlexiIC |
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| 2024-11-25 | 8-K | 10.1 | Collaboration Agreement, dated November 19, 2024, by and between SmartKem Limited and AUO |
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| 2024-11-08 | 10-Q | 10.1 | Joint Development Agreement, dated July 26, 2024, by and between SmartKem Limited and Shanghai Chip Foundation Semiconductor Technology Co., Ltd. |
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| 2024-03-27 | 10-K | 10.28 | Framework Supply Agreement, dated March 22, 2024, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2024-01-29 | 8-K | 10.2 | Form of Registration Rights Agreement |
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| 2024-01-29 | 8-K | 10.1 | Form of Consent Agreement |
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| 2023-08-28 | 8-K | 10.1 | Amendment to the 2021 Equity Incentive Plan. |
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| 2023-08-14 | 10-Q | 10.3 | License of Office Space, dated May 31, 2023, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2023-06-15 | 8-K | 10.2 | Form of Registration Rights Agreement |
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| 2023-06-15 | 8-K | 10.1 | Form of Purchase Agreement |
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| 2023-03-30 | 10-K | 10.25 | Employment Agreement, dated as of December 14, 2022, by and between the Registrant and Barbra Keck |
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| 2022-12-20 | 8-K | 10.1 | Offer Letter, effective December 14, 2022, by and between SmartKem, Inc. and Barbra Keck. |
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| 2022-09-19 | 8-K | 10.1 | Service Agreement, dated September 19, 2022, by and between SmartKem Limited and Robert Bahns. |
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| 2022-09-08 | 8-K | 10.1 | Service Agreement, dated September 7, 2022, by and between SmartKem Limited and Nigel Prue. |
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| 2022-08-23 | 10-Q/A | 10.3 | Renewal Lease by Reference of Lease of The Whole of the 8th Floor, Hexagon Tower, Manchester, M9 8GP, dated April 12, 2022, between AG Hexagon BV and SmartKem Limited |
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| 2022-08-23 | 10-K/A | 10.21 | Contract Variation relating to the Framework Services Agreement, dated February 23, 2021, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2022-05-13 | 10-Q | 10.3 | Renewal Lease by Reference of Lease of The Whole of the 8th Floor, Hexagon Tower, Manchester, M9 8GP, dated April 12, 2022, between AG Hexagon BV and SmartKem Limited |
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| 2022-03-28 | 10-K | 10.21 | Contract Variation relating to the Framework Services Agreement, dated February 23, 2021, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2022-01-27 | 8-K | 10.2 | Registration Rights Agreement, dated January 27, 2022, by and between the Company and the Purchasers. |
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| 2022-01-27 | 8-K | 10.1 | Subscription Agreement, dated January 27, 2022, by and between the Company and the Purchasers. |
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| 2021-02-24 | 8-K | 10.18 | Letter Agreement, dated as of February 23, 2021, among the Registrant and Octopus Titan VCT plc and certain related parties |
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| 2021-02-24 | 8-K | 10.17 | Form of Pre-Exchange Indemnity Agreement |
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| 2021-02-24 | 8-K | 10.16 | Form of Director and Officer Indemnification Agreement |
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| 2021-02-24 | 8-K | 10.15 | Debenture Agreement, dated January 26, 2021, by and between SmartKem Limited and FRCF 2 Limited |
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| 2021-02-24 | 8-K | 10.14 | Facility Agreement, dated January 26, 2021, by and between SmartKem Limited and FRCF 2 Limited |
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| 2021-02-24 | 8-K | 10.13 | Framework Services Agreement, dated February 23, 2021, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2021-02-24 | 8-K | 10.12 | Lease of The Whole of the 8th Floor, Hexagon Tower, Manchester, M9 8GP, dated April 16, 2019, between AG Hexagon BV and SmartKem Limited. |
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| 2021-02-24 | 8-K | 10.11 | Licence of Office Space, dated April 21, 2020, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2021-02-24 | 8-K | 10.10 | Licence of Office Space, dated September 16, 2020, by and between SmartKem Limited and CPI Innovation Services Limited |
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| 2021-02-24 | 8-K | 10.9 | Consultancy Agreement, dated as of February 23, 2021, by and between SmartKem Limited and B Brown Consultants Ltd. |
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| 2021-02-24 | 8-K | 10.8 | Employment Agreement, dated as of February 23, 2021, by and between SmartKem Limited and Simon Ogier |
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| 2021-02-24 | 8-K | 10.7 | Employment Agreement, dated as of February 23, 2021, by and between SmartKem Limited and Robert Bahns |
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| 2021-02-24 | 8-K | 10.6 | Employment Agreement, dated as of February 23, 2021, by and between the Registrant and Ian Jenks |
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| 2021-02-24 | 8-K | 10.5 | Form of Subscription Agreement |
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| 2021-02-24 | 8-K | 10.4 | Form of Lock-Up Agreement |
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| 2021-02-24 | 8-K | 10.3 | U.K. Tax Advantaged Sub-Plan |
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| 2021-02-24 | 8-K | 10.2 | 2021 Equity Incentive Plan |
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| 2021-02-24 | 8-K | 10.1 | Engagement Letter, dated December 15, 2020, by and between GP Nurmenkari Inc. and SmartKem Limited |
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