Rock Springs Capital Management LP Last Quarter Change: USA Stocks, New

Rock Springs Capital Management LP quarter change: USA Stocks, New

In share positions in stocks (listed in the US), from the quarter ended 2026-03-31 to 2026-06-30, Rock Springs Capital Management LP opened 17 positions, added to 37, reduced 27, sold out of 10 and left 15 unchanged. The largest increase in value was RVMD (+$89,363,258); the largest decrease was ACLX (-$19,503,210).

ASND: Country of operation —; Class ORD SHS; Shares 2026-03-31 0; Shares 2026-06-30 168,750.
AVLN: Country of operation United States; Class COM SHS; Shares 2026-03-31 0; Shares 2026-06-30 662,918.
COAG: Country of operation United States; Class COM SHS; Shares 2026-03-31 0; Shares 2026-06-30 575,432.
PBLS: Country of operation United States; Class COM; Shares 2026-03-31 0; Shares 2026-06-30 578,028.

Two Form 13F-HR filings compared (SEC CIK 1595725): 2026-03-31 (filed 2026-05-15) and 2026-06-30 (filed 2026-08-14). Rows for the same security, class and put/call are added together. Value change is the filed value at each quarter end, so it includes the price move; share change is the position change.

Stock	Country of operation	Class	Shares 2026-06-30	Share change	Value 2026-03-31	Value 2026-06-30	Value change
ASND ASCENDIS PHARMA A/S		ORD SHS	168,750	+168,750	$0	$45,009,000	+$45,009,000
AVLN AVALYN PHARMACEUTICALS INC	United States	COM SHS	662,918	+662,918	$0	$21,823,261	+$21,823,261
COAG HEMAB THERAPEUTICS HLDGS INC	United States	COM SHS	575,432	+575,432	$0	$21,135,617	+$21,135,617
PBLS PARABILIS MEDICINES INC	United States	COM	578,028	+578,028	$0	$15,820,626	+$15,820,626
OMER OMEROS CORP	United States	COM	718,499	+718,499	$0	$6,832,925	+$6,832,925
DFTX DEFINIUM THERAPEUTICS INC	United States	COM SHS	143,187	+143,187	$0	$6,735,516	+$6,735,516
MOBI MOBIA MED INC	United States	COMMON STOCK	418,200	+418,200	$0	$5,603,880	+$5,603,880
TRVI TREVI THERAPEUTICS INC	United States	COM	260,000	+260,000	$0	$4,849,000	+$4,849,000
SYRE SPYRE THERAPEUTICS INC	United States	COM NEW	42,254	+42,254	$0	$3,751,310	+$3,751,310
NGEN NERVGEN PHARMA CORP		COM	1,208,231	+1,208,231	$0	$2,488,956	+$2,488,956
MDT MEDTRONIC PLC	Ireland	SHS	30,900	+30,900	$0	$2,417,307	+$2,417,307
SGMT SAGIMET BIOSCIENCES INC	United States	COM SER A	250,000	+250,000	$0	$1,932,500	+$1,932,500
CAPR CAPRICOR THERAPEUTICS INC	United States	COM NEW	74,448	+74,448	$0	$1,792,708	+$1,792,708
ALT ALTIMMUNE INC	United States	COM NEW	471,465	+471,465	$0	$1,433,254	+$1,433,254
KLRA KAILERA THERAPEUTICS INC	United States	COMMON STOCK	65,000	+65,000	$0	$1,431,950	+$1,431,950
AXSM AXSOME THERAPEUTICS INC.	United States	COM	5,500	+5,500	$0	$1,346,235	+$1,346,235
GKOS GLAUKOS CORP	United States	COM	4,750	+4,750	$0	$663,860	+$663,860

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