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Palo Alto Investors LP Last Quarter Change: USA Stocks, Reduced

Palo Alto Investors LP quarter change: USA Stocks, Reduced

In share positions in stocks (listed in the US), from the quarter ended 2026-03-31 to 2026-06-30, Palo Alto Investors LP opened 3 positions, added to 5, reduced 13, sold out of 2 and left 25 unchanged. The largest increase in value was PTCT (+$12,161,183); the largest decrease was INSM (-$23,766,239).

  • INSM: Country of operation United States; Class COM PAR $.01; Shares 2026-03-31 415,269; Shares 2026-06-30 413,980.
  • PTCT: Country of operation United States; Class COM; Shares 2026-03-31 921,607; Shares 2026-06-30 918,846.
  • ACAD: Country of operation United States; Class COM; Shares 2026-03-31 2,872,695; Shares 2026-06-30 2,864,096.
  • ANAB: Country of operation United States; Class COM; Shares 2026-03-31 638,161; Shares 2026-06-30 603,489.

Two Form 13F-HR filings compared (SEC CIK 1306923): 2026-03-31 (filed 2026-05-15) and 2026-06-30 (filed 2026-08-19). Rows for the same security, class and put/call are added together. Value change is the filed value at each quarter end, so it includes the price move; share change is the position change.

StockCountry of operationClassShares 2026-03-31Shares 2026-06-30Share changeValue 2026-03-31Value 2026-06-30Value change
INSM
INSMED INC
United StatesCOM PAR $.01415,269413,980-1,289$67,904,787$44,138,548-$23,766,239
PTCT
PTC THERAPEUTICS INC
United StatesCOM921,607918,846-2,761$62,789,085$74,950,268+$12,161,183
ACAD
ACADIA PHARMACEUTICALS INC
United StatesCOM2,872,6952,864,096-8,599$63,946,191$72,461,629+$8,515,438
ANAB
ANAPTYSBIO INC
United StatesCOM638,161603,489-34,672$35,392,409$40,735,508+$5,343,099
UTHR
UNITED THERAPEUTICS CORP
United StatesCOM62,80962,587-222$37,244,481$33,911,514-$3,332,967
TVTX
TRAVERE THERAPEUTICS INC
United StatesCOM230,453167,525-62,928$6,846,759$9,517,095+$2,670,336
ALGN
ALIGN TECHNOLOGY INC
United StatesCOM41,52031,389-10,131$7,117,774$5,294,069-$1,823,705
PYXS
PYXIS ONCOLOGY INC
United StatesCOMMON STOCK1,010,510864,277-146,233$1,475,345$2,601,474+$1,126,129
PRTA
PROTHENA CORP PLC
IrelandSHS1,208,5681,143,155-65,413$11,747,281$11,191,487-$555,794
BMRN
BIOMARIN PHARMACEUTICAL INC
United StatesCOM685,182682,777-2,405$38,705,931$39,068,500+$362,569
NUVB
NUVATION BIO INC
United StatesCOM CL A508,846326,609-182,237$2,182,949$1,855,139-$327,810
IOVA
IOVANCE BIOTHERAPEUTICS INC
United StatesCOM6,349,5635,296,209-1,053,354$22,286,966$22,032,229-$254,737
ORKA
ORUKA THERAPEUTICS INC - Restricted
United StatesCOM59,98533,546-26,439$2,942,264$3,192,573+$250,309

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