| 2026-06-17 | 8-K | 10.1 | Voting and Support Agreement, dated as of June 15, 2026 by and among SP Evolution HoldCo II, LLC, SP Evolution BidCo II, LLC, Dr. Walter S. Woltosz and Virginia E. Woltosz. |
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| 2026-02-18 | 8-K | 10.1 | Third Amendment to 2021 Equity Incentive Plan, of Simulations Plus, Inc. dated February 12, 2026. |
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| 2025-12-08 | 8-K | 10.7 | Employment Agreement between Simulations Plus, Inc. and Viera Lukacova, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.6 | Employment Agreement between Simulations Plus, Inc. and Josh Fohey, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.5 | Employment Agreement between Simulations Plus, Inc. and Erik Guffrey, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.4 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Jill Fiedler-Kelly, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.3 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and John DiBella, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.2 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Will Frederick, dated December 2, 2025. |
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| 2025-12-08 | 8-K | 10.1 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Shawn O’Connor, dated December 2, 2025. |
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| 2024-06-12 | 8-K | 10.1 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Michael Raymer, dated June 11, 2024. |
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| 2024-02-12 | 8-K | 10.1 | Second Amendment to 2021 Equity Incentive Plan, of Simulations Plus, Inc., dated February 8, 2024. |
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| 2023-11-01 | 8-K | 10.5 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Jill Fiedler-Kelly, dated June 16, 2023. |
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| 2023-11-01 | 8-K | 10.4 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and John DiBella, dated June 16, 2023. |
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| 2023-11-01 | 8-K | 10.3 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Brett Howell, dated June 16, 2023. |
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| 2023-11-01 | 8-K | 10.2 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Will Frederick, dated November 1, 2023. |
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| 2023-11-01 | 8-K | 10.1 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Shawn O’Connor, dated November 1, 2023. |
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| 2023-06-20 | 8-K | 10.2 | Amended and Restated Employment Agreement between Simulations Plus, Inc. and Steven Chang, dated June 16, 2023. |
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| 2023-06-20 | 8-K | 10.1 | Earnout Agreement by and among Simulations Plus, Inc., Insight Merger Sub, Inc., Immunetrics, Inc. and LaunchCyte LLC, dated June 16, 2023. |
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| 2023-04-07 | 10-Q | 10.3 | Fourth Amendment to Lease by and between the Company and Crest Development LLC, dated as of February 17, 2023. |
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| 2023-02-13 | 8-K | 10.1 | First Amendment to 2021 Equity Incentive Plan, of Simulations Plus, Inc., dated February 9, 2023. |
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| 2023-01-12 | 8-K | 10.1 | Confirmation for Fixed Dollar Accelerated Share Repurchase Transaction, dated as of January 11, 2023, by and between Simulations Plus, Inc. and Morgan Stanley & Co. LLC. |
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| 2022-10-28 | 10-K | 10.14 | Employment Agreement by and between the Company and Jill Fiedler-Kelly, dated January 1, 2022. |
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| 2022-10-28 | 10-K | 10.13 | Employment Agreement by and between the Company and Brett Howell, dated January 1, 2022. |
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| 2022-10-28 | 10-K | 10.12 | Employment Agreement by and between the Company and John DiBella, dated January 1, 2022. |
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| 2021-11-19 | 8-K | 10.1 | First Amendment to Employment Agreement, by and between Simulations Plus, Inc. and Shawn O’Connor, dated November 19, 2021. |
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| 2021-06-08 | 8-K | 10.1 | EQUITY INCENTIVE PLAN |
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| 2021-04-14 | 10-Q | 10.2 | FIRST SEPARATION AGREEMENT |
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| 2021-01-11 | 10-Q | 10.2 | EMPLOYMENT AGREEMENT BY AND BETWEEN THE COMPANY AND WILLIAM W. FREDERICK |
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| 2021-01-04 | 8-K | 10.1 | THIRD AMENDMENT TO LEASE |
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| 2020-09-09 | 8-K | 10.1 | EMPLOYMENT AGREEMENT |
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| 2018-07-10 | 10-Q | 10.10 | EMPLOYMENT AGREEMENT - SHAWN O'CONNOR |
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| 2017-09-06 | 8-K | 10.3 | EMPLOYMENT AGREEMENT |
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| 2017-09-06 | 8-K | 10.2 | EMPLOYMENT AGREEMENT |
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| 2017-09-06 | 8-K | 10.1 | EMPLOYMENT AGREEMENT |
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| 2017-07-10 | 10-Q | 10.1 | STOCK OPTION PLAN |
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| 2017-04-10 | 10-Q | 10.12 | EQUITY INCENTIVE PLAN |
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| 2016-11-14 | 10-K | 10.4.D | AMENDMENT TO LEASE |
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| 2016-08-11 | 8-K | 10.1 | EMPLOYMENT AGREEMENT |
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| 2016-08-10 | 8-K | 10.1 | FORM OF INDEMNIFICATION AGREEMENT |
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| 2014-05-19 | 8-K | 10.1 | TERMINATION AND NON-ASSERTION AGREEMENT |
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| 2014-04-09 | 10-Q | 10.3 | AMENDED STOCK OPTION PLAN |
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| 2013-11-18 | 10-K | 10.9 | EMPLOYMENT AGREEMENT |
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| 2013-07-10 | 10-Q | 10.8 | AMENDMENT TO LEASE AGREEMENT |
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| 2011-11-29 | 10-K | 10.48 | EMPLOYMENT AGREEMENT |
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| 2011-11-16 | 8-K | 10.1 | STOCK PURCHASE AGREEMENT |
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| 2011-09-22 | 8-K | 10.1 | BILL OF SALE |
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| 2010-11-29 | 10-K | 10.47 | EXTENSION OF LEASE |
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| 2010-03-01 | 10-K/A | 10.41 | TECHNOLOGY TRANSFER AGREEMENT |
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| 2010-03-01 | 10-K/A | 10.34 | OEM/REMARKETING AGREEMENT |
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| 2010-01-13 | 10-Q | 10.46 | 2007 STOCK OPTION PLAN |
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| 2009-11-30 | 10-K | 10.45 | EMPLOYMENT AGREEMENT |
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