| 2026-08-10 | 10-Q | 10.1 | Orchestra BioMed Holdings, Inc. 2026 Employee Stock Purchase Plan. |
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| 2026-05-12 | 10-Q | 10.2 | Third Amendment to Loan and Security Agreement by and among the Company and certain of its subsidiaries, the lenders named therein and Hercules Capital, Inc., dated as of April 6, 2026. |
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| 2026-05-12 | 10-Q | 10.1 | First Amendment to Loan and Security Agreement by and among the Company and certain of its subsidiaries, the lenders named therein and Hercules Capital, Inc., dated as of December 30, 2024. |
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| 2025-11-10 | 10-Q | 10.15 | Form of Restricted Stock Unit Grant Notice and Award Agreement for the Orchestra BioMed Holdings, Inc. 2025 New Hire Inducement Plan. |
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| 2025-11-10 | 10-Q | 10.14 | Form of Stock Option Grant Notice and Stock Option Agreement for the Orchestra BioMed Holdings, Inc. 2025 New Hire Inducement Plan. |
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| 2025-11-10 | 10-Q | 10.13 | Orchestra BioMed Holdings, Inc. 2025 New Hire Inducement Plan. |
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| 2025-10-28 | 8-K | 10.3 | Lockup Agreement, by and among the Company, Terumo Corporation and Terumo Medical Corporation, dated October 24, 2025 |
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| 2025-10-28 | 8-K | 10.2 | Stock Purchase Agreement, by and between the Company and Terumo Medical Corporation, dated October 24, 2025 |
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| 2025-10-28 | 8-K | 10.1 | Termination and ROFR Agreement, by and between the Orchestra BioMed, Inc., Terumo Corporation and Terumo Medical Corporation, dated October 24, 2025 |
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| 2025-08-12 | 10-Q | 10.9 | Amendment No. 1 to Exclusive License and Collaboration Agreement, dated as of August 1, 2025, by and among the Company, BackBeat Medical, LLC and Medtronic, Inc. |
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| 2025-08-12 | 10-Q | 10.8 | Registration Rights Agreement, dated August 4, 2025, by and among the Company, Ligand Pharmaceuticals Incorporated and Covidien Group S.à.r.l. |
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| 2025-08-12 | 10-Q | 10.6 | Amendment No. 1 to Stock Purchase Agreement, by and between the Company and Covidien Group S.à.r.l., dated August 1, 2025. |
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| 2025-07-31 | 8-K | 10.7 | Form of Registration Rights Agreement |
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| 2025-07-31 | 8-K | 10.6 | Second Amendment to Loan and Security Agreement, by and among the Company and certain of its subsidiaries, the lenders named therein and Hercules Capital, Inc., dated July 31, 2025. |
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| 2025-07-31 | 8-K | 10.5 | Stock Purchase Agreement, by and between the Company and Covidien Group S.à.r.l., dated July 31, 2025 |
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| 2025-07-31 | 8-K | 10.4 | Form of Secured Subordinated Promissory Note by and among the Company, Orchestra BioMed, Inc, BackBeat Medical, LLC and Medtronic Inc. |
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| 2025-07-31 | 8-K | 10.3 | Loan Agreement, by and among the Company, Orchestra BioMed, Inc, BackBeat Medical, LLC and Medtronic Inc., dated July 31, 2025 |
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| 2025-07-31 | 8-K | 10.2 | Stock Purchase Agreement, by and between the Company and Ligand Pharmaceuticals, Incorporated, dated July 31, 2025 |
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| 2025-07-31 | 8-K | 10.1 | Revenue Participation Right Purchase and Sale Agreement, by and between the Company and Ligand Pharmaceuticals Inc., dated July 31, 2025 |
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| 2025-03-31 | 10-K | 10.19 | Amendment to Distribution Agreement, by and among Orchestra Biomed, Inc., Terumo Corporation and Terumo Medical Corporation, dated June 30, 2020. |
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| 2025-03-31 | 10-K | 10.18 | Letter Agreement to Distribution Agreement, by and among Orchestra Biomed, Inc., Terumo Corporation and Terumo Medical Corporation, dated June 13, 2019. |
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| 2025-03-31 | 10-K | 10.13 | Lease Agreement, dated as of September 9, 2024, by and between Victoriana Building, LLC and Orchestra BioMed, Inc. |
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| 2024-11-12 | 10-Q | 10.3 | Commercial Lease, by and between Caliber Therapeutics, Inc. and Union Square, L.P. for facilities at 150 and 140 Union Square Drive, New Hope, Pennsylvania, dated December 14, 2009 and amended June 22, 2010, February 1, 2011, September 18, 2012, January 15, 2015, January 20, 2017, August 8, 2017, January 29, 2019, August 30, 2019 and August 8, 2024. |
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| 2024-11-12 | 10-Q | 10.2 | Bonus Letter Agreement, dated November 8, 2024, by and between the Company and Darren Sherman. |
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| 2024-11-12 | 10-Q | 10.1 | Loan and Security Agreement, dated November 6, 2024, by and among the Company and certain of its subsidiaries, the lenders named therein and Hercules Capital, Inc., as administrative agent and collateral agent for itself and the lenders. |
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| 2024-05-13 | 10-Q | 10.1 | First Amendment of Lease dated as of November 22, 2022, by and between ESRT One Grand Central Place, L.L.C., and Orchestra BioMed, Inc. |
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| 2024-03-27 | 10-K | 10.33 | Orchestra BioMed Holdings, Inc. Non-Employee Director Compensation Policy. |
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| 2023-11-28 | 8-K | 10.1 | Second Amended and Restated Registration Rights and Lock-Up Agreement, dated November 21, 2023 |
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| 2023-06-08 | 8-K | 10.2 | Offer Letter, dated as of June 5, 2023, by and between the Company and Andrew Taylor. |
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| 2023-06-08 | 8-K | 10.1 | Consulting Agreement, dated as of June 5, 2023, by and between the Company and Michael Kaswan. |
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| 2023-01-31 | 8-K | 10.20 | EMPLOYMENT AGREEMENT, BY AND BETWEEN ORCHESTRA BIOMED HOLDINGS, INC. AND DARREN R. SHERMAN, DATED JANUARY 26, 2023 |
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| 2023-01-31 | 8-K | 10.19 | EMPLOYMENT AGREEMENT, BY AND BETWEEN ORCHESTRA BIOMED HOLDINGS, INC. AND DAVID P. HOCHMAN, DATED JANUARY 26, 2023 |
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| 2023-01-31 | 8-K | 10.9 | FORM OF RESTRICTED STOCK UNIT AWARD GRANT NOTICE AND RESTRICTED STOCK UNIT AWARD AGREEMENT UNDER THE ORCHESTRA BIOMED HOLDINGS, INC. 2023 EQUITY INCENTIVE PLAN |
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| 2023-01-31 | 8-K | 10.8 | FORM OF STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT UNDER THE ORCHESTRA BIOMED HOLDINGS,INC. 2023 EQUITY INCENTIVE PLAN |
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| 2023-01-31 | 8-K | 10.7 | ORCHESTRA BIOMED HOLDINGS, INC. 2023 EQUITY INCENTIVE PLAN |
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| 2023-01-31 | 8-K | 10.2 | FORM OF INDEMNIFICATION AGREEMENT OF ORCHESTRA BIOMED HOLDINGS, INC |
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| 2023-01-31 | 8-K | 10.1 | AMENDED AND RESTATED REGISTRATION RIGHTS AND LOCK-UP AGREEMENT, BY AND AMONG HEALTH SCIENCES ACQUISITIONS CORPORATION 2, EQUITYHOLDERS THEREOF AND CERTAIN STOCKHOLDERS OF ORCHESTRA BIOMED, INC |
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| 2022-10-21 | 8-K | 10.2 | AMENDMENT TO BACKSTOP AGREEMENT DATED AS OF OCTOBER 21, 2022, BY AND AMONG HEALTH SCIENCES ACQUISITIONS CORPORATION 2, ORCHESTRA BIOMED, INC., RTW MASTER FUND, LTD., RTW INNOVATION MASTER FUND, LTD., AND RTW VENTURE FUND LIMITED |
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| 2022-10-21 | 8-K | 10.1 | AMENDMENT TO FORWARD PURCHASE AGREEMENT DATED AS OF OCTOBER 21, 2022, BY AND AMONG HEALTH SCIENCES ACQUISITIONS CORPORATION 2, ORCHESTRA BIOMED, INC., AND RTW MASTER FUND, LTD., RTW INNOVATION MASTER FUND, LTD., AND RTW VENTURE FUND LIMITED |
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| 2022-07-05 | 8-K | 10.7 | Form of Earnout Election Agreement. |
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| 2022-07-05 | 8-K | 10.6 | Form of Amended and Restated Registration Rights and Lock-Up Agreement |
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| 2022-07-05 | 8-K | 10.5 | Orchestra Support Agreement dated as of July 4, 2022 by and among Health Sciences Acquisitions Corporation 2, Orchestra BioMed, Inc., and Covidien Group S.À.R.L. |
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| 2022-07-05 | 8-K | 10.4 | Parent Support Agreement dated as of July 4, 2022 by and among Health Sciences Acquisitions Corporation 2, Orchestra BioMed, Inc., HSAC 2 Holdings, LLC, Alice Lee, Stephanie A. Sirota, Pedro Granadillo, Stuart Peltz, Michael Brophy, and Carsten Boess |
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| 2022-07-05 | 8-K | 10.3 | Backstop Agreement dated as of July 4, 2022, by and among Health Sciences Acquisitions Corporation 2, Orchestra BioMed, Inc., RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd., and RTW Venture Fund Limited |
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| 2022-07-05 | 8-K | 10.2 | Forward Purchase Agreement dated as of July 4, 2022, by and among Health Sciences Acquisitions Corporation 2, Orchestra BioMed, Inc., and RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd., and RTW Venture Fund Limited |
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| 2022-07-05 | 8-K | 10.1 | Forward Purchase Agreement dated as of July 4, 2022, by and among Health Sciences Acquisitions Corporation 2, Orchestra BioMed, Inc., and Covidien Group S.à.r.l. |
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| 2020-08-07 | 8-K | 10.8 | PURCHASE AGREEMENT, DATED AUGUST 3, 2020, BY AND BETWEEN THE COMPANY AND HSAC 2 HOLDINGS, LLC |
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| 2020-08-07 | 8-K | 10.7 | ADMINISTRATIVE SERVICES AGREEMENT, DATED AUGUST 3, 2020, BY AND BETWEEN THE COMPANY AND HSAC 2 HOLDINGS, LLC |
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| 2020-08-07 | 8-K | 10.6 | SUBSCRIPTION AGREEMENT, DATED AUGUST 3, 2020, BY AND BETWEEN THE COMPANY AND CHARDAN CAPITAL MARKETS, LLC |
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| 2020-08-07 | 8-K | 10.5 | INDEMNITY AGREEMENTS, DATED AUGUST 3, 2020, BY AND AMONG THE COMPANY AND THE DIRECTORS AND OFFICERS OF THE COMPANY |
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| 2020-08-07 | 8-K | 10.4 | REGISTRATION RIGHTS AGREEMENT, DATED AUGUST 3, 2020, BY AND BETWEEN THE COMPANY AND INITIAL STOCKHOLDERS |
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| 2020-08-07 | 8-K | 10.3 | SHARE ESCROW AGREEMENT, DATED AUGUST 3, 2020, AMONG THE COMPANY, CONTINENTAL STOCK TRANSFER & TRUST COMPANY AND THE INITIAL STOCKHOLDERS |
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| 2020-08-07 | 8-K | 10.2 | INVESTMENT MANAGEMENT TRUST AGREEMENT, DATED AUGUST 3, 2020, BY AND BETWEEN CONTINENTAL STOCK TRANSFER & TRUST COMPANY AND THE COMPANY |
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| 2020-08-07 | 8-K | 10.1 | LETTER AGREEMENTS, DATED AUGUST 3, 2020, AMONG THE COMPANY AND THE COMPANY'S OFFICERS, DIRECTORS AND INITIAL STOCKHOLDERS |
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