NASDAQ:IONS | Roast Me | IONIS PHARMACEUTICALS INC

52/120 All 120 Win/Lose results shown below

Every strict quarterly win earns 1 point. A loss, tie, or unavailable scoring value earns 0. Gray context columns never affect the score. CEO quarterly pay is the explicitly marked annual ÷ 4 estimate.

Trailing 1 year (4 quarters): 6 wins, 6 lossesLast fetched: 4 Sept 2026

Complete point ledger

Each cell identifies the missing side explicitly. Unavailable evidence scores 0 only in Win/Lose columns; gray columns award no points.

QuarterTotal returnRevenue growthEPS growthNet marginNon-scoringTrailing P/ENon-scoringPrice/bookNon-scoringCEO quarterly payNon-scoringImplied DilutionNon-scoringImplied BuybackNon-scoring
2026-Q21/3 LoseIONS / S&P
5.59% / 15.20%
LoseIONS / S&P
-7.41% / 15.00%
WinIONS / S&P
89.13% / 50.40%
Non-scoringIONS / S&P
-64.66% / 15.70%
Non-scoringIONS / S&P
IONS unavailable / 28.47
Non-scoringIONS / S&P
29.87 / S&P unavailable
Non-scoringIONS / S&P
IONS unavailable / S&P unavailable
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.36b
2026-Q11/3 LoseIONS / S&P
-5.08% / -4.33%
WinIONS / S&P
47.53% / 11.30%
LoseIONS / S&P
-30.10% / 27.70%
Non-scoringIONS / S&P
-30.90% / 14.80%
Non-scoringIONS / S&P
IONS unavailable / 25.43
Non-scoringIONS / S&P
25.35 / S&P unavailable
Non-scoringIONS / S&P
IONS unavailable / S&P unavailable
Non-scoringIONS / S&P
IONS unavailable / $0.27b
Non-scoringIONS / S&P
IONS unavailable / $0.00b
2025-Q42/3 WinIONS / S&P
20.93% / 2.65%
WinIONS / S&P
33.83% / 9.00%
LoseIONS / S&P
-19.08% / 13.40%
Non-scoringIONS / S&P
-40.41% / 13.20%
Non-scoringIONS / S&P
IONS unavailable / 28.48
Non-scoringIONS / S&P
26.41 / 5.39
Non-scoringIONS / S&P
IONS unavailable / $4.42m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.20b
2025-Q32/3 WinIONS / S&P
65.58% / 8.12%
WinIONS / S&P
20.41% / 4.61%
LoseIONS / S&P
-30.74% / 13.45%
Non-scoringIONS / S&P
-26.51% / 11.78%
Non-scoringIONS / S&P
IONS unavailable / 28.13
Non-scoringIONS / S&P
17.06 / 5.27
Non-scoringIONS / S&P
IONS unavailable / $4.42m
Non-scoringIONS / S&P
IONS unavailable / $0.11b
Non-scoringIONS / S&P
IONS unavailable / $0.00b
2025-Q22/3 WinIONS / S&P
30.96% / 10.94%
WinIONS / S&P
16.05% / 4.83%
LoseIONS / S&P
-26.98% / 10.63%
Non-scoringIONS / S&P
-28.41% / 11.45%
Non-scoringIONS / S&P
IONS unavailable / 27.10
Non-scoringIONS / S&P
9.96 / 5.01
Non-scoringIONS / S&P
IONS unavailable / $4.42m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.23b
2025-Q11/3 LoseIONS / S&P
-13.70% / -4.27%
LoseIONS / S&P
-7.64% / 4.98%
WinIONS / S&P
11.99% / 10.57%
Non-scoringIONS / S&P
-63.86% / 11.39%
Non-scoringIONS / S&P
IONS unavailable / 26.23
Non-scoringIONS / S&P
10.09 / 4.69
Non-scoringIONS / S&P
IONS unavailable / $4.42m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.10b
2024-Q41/3 LoseIONS / S&P
-12.73% / 2.41%
LoseIONS / S&P
-10.48% / 5.25%
WinIONS / S&P
18.75% / 6.15%
Non-scoringIONS / S&P
-64.37% / 11.29%
Non-scoringIONS / S&P
IONS unavailable / 28.60
Non-scoringIONS / S&P
9.38 / 4.99
Non-scoringIONS / S&P
IONS unavailable / $4.28m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.08b
2024-Q31/3 LoseIONS / S&P
-15.95% / 5.89%
WinIONS / S&P
30.57% / 5.89%
LoseIONS / S&P
-14.98% / 6.11%
Non-scoringIONS / S&P
-44.68% / 10.87%
Non-scoringIONS / S&P
IONS unavailable / 28.09
Non-scoringIONS / S&P
9.54 / 4.94
Non-scoringIONS / S&P
IONS unavailable / $4.28m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.21b
2024-Q23/3 WinIONS / S&P
9.94% / 4.28%
WinIONS / S&P
29.00% / 5.38%
WinIONS / S&P
16.13% / 5.12%
Non-scoringIONS / S&P
-44.96% / 10.85%
Non-scoringIONS / S&P
IONS unavailable / 27.64
Non-scoringIONS / S&P
26.39 / 4.79
Non-scoringIONS / S&P
IONS unavailable / $4.28m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.36b
2024-Q12/3 LoseIONS / S&P
-14.31% / 10.56%
WinIONS / S&P
34.84% / 5.71%
WinIONS / S&P
15.58% / 5.59%
Non-scoringIONS / S&P
-49.54% / 10.81%
Non-scoringIONS / S&P
IONS unavailable / 27.02
Non-scoringIONS / S&P
21.32 / 4.71
Non-scoringIONS / S&P
IONS unavailable / $4.28m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.12b
2023-Q42/3 LoseIONS / S&P
11.53% / 11.69%
WinIONS / S&P
34.10% / 6.81%
WinIONS / S&P
34.74% / 7.78%
Non-scoringIONS / S&P
-46.50% / 11.19%
Non-scoringIONS / S&P
IONS unavailable / 24.35
Non-scoringIONS / S&P
18.88 / 4.31
Non-scoringIONS / S&P
IONS unavailable / $4.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.01b
2023-Q31/3 WinIONS / S&P
10.55% / -3.27%
LoseIONS / S&P
-29.75% / 7.52%
LoseIONS / S&P
-4200.00% / -5.03%
Non-scoringIONS / S&P
-66.57% / 10.84%
Non-scoringIONS / S&P
IONS unavailable / 23.93
Non-scoringIONS / S&P
20.62 / 3.98
Non-scoringIONS / S&P
IONS unavailable / $4.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.24b
2023-Q22/3 WinIONS / S&P
14.80% / 8.74%
LoseIONS / S&P
-25.71% / 9.50%
WinIONS / S&P
1105.56% / -8.57%
Non-scoringIONS / S&P
-49.01% / 10.88%
Non-scoringIONS / S&P
IONS unavailable / 24.01
Non-scoringIONS / S&P
13.72 / 4.19
Non-scoringIONS / S&P
IONS unavailable / $4.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.17b
2023-Q11/3 LoseIONS / S&P
-5.37% / 7.50%
LoseIONS / S&P
-31.49% / 10.77%
WinIONS / S&P
23000.00% / -15.69%
Non-scoringIONS / S&P
-57.10% / 10.82%
Non-scoringIONS / S&P
IONS unavailable / 22.66
Non-scoringIONS / S&P
10.51 / 3.93
Non-scoringIONS / S&P
IONS unavailable / $4.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.13b
2022-Q41/3 LoseIONS / S&P
-14.61% / 7.56%
LoseIONS / S&P
-27.53% / 11.88%
WinIONS / S&P
900.00% / -17.99%
Non-scoringIONS / S&P
-45.92% / 11.09%
Non-scoringIONS / S&P
IONS unavailable / 22.65
Non-scoringIONS / S&P
9.37 / 3.75
Non-scoringIONS / S&P
IONS unavailable / $3.70m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.15b
2022-Q32/3 WinIONS / S&P
19.48% / -4.88%
WinIONS / S&P
32.50% / 13.47%
LoseIONS / S&P
-101.62% / -1.41%
Non-scoringIONS / S&P
0.84% / 12.28%
Non-scoringIONS / S&P
858.00 / 20.58
Non-scoringIONS / S&P
10.57 / 3.60
Non-scoringIONS / S&P
IONS unavailable / $3.70m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.17b
2022-Q22/3 WinIONS / S&P
-0.05% / -16.10%
WinIONS / S&P
23.42% / 13.71%
LoseIONS / S&P
-95.42% / 11.04%
Non-scoringIONS / S&P
-3.32% / 13.03%
Non-scoringIONS / S&P
IONS unavailable / 20.28
Non-scoringIONS / S&P
8.40 / 3.78
Non-scoringIONS / S&P
IONS unavailable / $3.70m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.17b
2022-Q12/3 WinIONS / S&P
21.72% / -4.60%
WinIONS / S&P
18.84% / 15.97%
LoseIONS / S&P
-99.72% / 42.23%
Non-scoringIONS / S&P
-0.46% / 14.22%
Non-scoringIONS / S&P
IONS unavailable / 22.19
Non-scoringIONS / S&P
7.40 / 4.51
Non-scoringIONS / S&P
IONS unavailable / $3.70m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.20b
2021-Q40/3 LoseIONS / S&P
-9.27% / 11.03%
LoseIONS / S&P
11.13% / 15.00%
LoseIONS / S&P
-94.03% / 96.40%
Non-scoringIONS / S&P
-3.53% / 15.13%
Non-scoringIONS / S&P
IONS unavailable / 23.63
Non-scoringIONS / S&P
5.57 / 4.73
Non-scoringIONS / S&P
IONS unavailable / $3.63m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.13b
2021-Q30/3 LoseIONS / S&P
-15.92% / 0.58%
LoseIONS / S&P
-29.16% / 10.77%
LoseIONS / S&P
-1021.28% / 69.42%
Non-scoringIONS / S&P
-91.98% / 14.13%
Non-scoringIONS / S&P
IONS unavailable / 25.35
Non-scoringIONS / S&P
8.93 / 4.38
Non-scoringIONS / S&P
IONS unavailable / $3.63m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.19b
2021-Q20/3 LoseIONS / S&P
-11.28% / 8.55%
LoseIONS / S&P
-26.88% / 6.58%
LoseIONS / S&P
-573.49% / 51.81%
Non-scoringIONS / S&P
-79.94% / 13.34%
Non-scoringIONS / S&P
IONS unavailable / 26.70
Non-scoringIONS / S&P
9.65 / 4.43
Non-scoringIONS / S&P
IONS unavailable / $3.63m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.11b
2021-Q10/3 LoseIONS / S&P
-20.48% / 6.17%
LoseIONS / S&P
-26.21% / -1.06%
LoseIONS / S&P
-454.00% / 7.39%
Non-scoringIONS / S&P
-69.89% / 11.60%
Non-scoringIONS / S&P
IONS unavailable / 30.50
Non-scoringIONS / S&P
9.31 / 4.23
Non-scoringIONS / S&P
IONS unavailable / $3.63m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.10b
2020-Q41/3 WinIONS / S&P
19.16% / 12.15%
LoseIONS / S&P
-35.04% / -3.72%
LoseIONS / S&P
-267.37% / -33.42%
Non-scoringIONS / S&P
-60.92% / 8.86%
Non-scoringIONS / S&P
IONS unavailable / 39.26
Non-scoringIONS / S&P
10.68 / 4.05
Non-scoringIONS / S&P
IONS unavailable / $3.17m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.01b
2020-Q31/3 LoseIONS / S&P
-19.52% / 8.93%
WinIONS / S&P
13.60% / -2.04%
LoseIONS / S&P
-85.27% / -27.10%
Non-scoringIONS / S&P
8.44% / 9.24%
Non-scoringIONS / S&P
84.30 / 34.27
Non-scoringIONS / S&P
4.80 / 3.65
Non-scoringIONS / S&P
IONS unavailable / $3.17m
Non-scoringIONS / S&P
IONS unavailable / $0.02b
Non-scoringIONS / S&P
IONS unavailable / $0.00b
2020-Q22/3 WinIONS / S&P
24.70% / 20.54%
WinIONS / S&P
17.78% / -0.46%
LoseIONS / S&P
-72.15% / -27.11%
Non-scoringIONS / S&P
13.75% / 9.37%
Non-scoringIONS / S&P
63.60 / 31.29
Non-scoringIONS / S&P
5.97 / 3.44
Non-scoringIONS / S&P
IONS unavailable / $3.17m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.03b
2020-Q11/3 LoseIONS / S&P
-21.73% / -19.60%
WinIONS / S&P
27.41% / 3.47%
LoseIONS / S&P
-62.96% / -14.75%
Non-scoringIONS / S&P
16.07% / 10.68%
Non-scoringIONS / S&P
42.74 / 22.80
Non-scoringIONS / S&P
4.84 / 2.92
Non-scoringIONS / S&P
IONS unavailable / $3.17m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.05b
2019-Q41/3 LoseIONS / S&P
0.83% / 9.07%
WinIONS / S&P
87.20% / 5.36%
LoseIONS / S&P
-8.21% / 2.99%
Non-scoringIONS / S&P
24.78% / 12.81%
Non-scoringIONS / S&P
30.48 / 22.78
Non-scoringIONS / S&P
5.76 / 3.53
Non-scoringIONS / S&P
IONS unavailable / $3.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.05b
2019-Q31/3 LoseIONS / S&P
-6.78% / 1.70%
WinIONS / S&P
42.70% / 5.02%
LoseIONS / S&P
-1129.03% / 0.21%
Non-scoringIONS / S&P
52.35% / 12.41%
Non-scoringIONS / S&P
19.60 / 22.44
Non-scoringIONS / S&P
6.31 / 3.30
Non-scoringIONS / S&P
IONS unavailable / $3.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.09b
2019-Q21/3 LoseIONS / S&P
-20.82% / 4.30%
WinIONS / S&P
45.65% / 6.64%
LoseIONS / S&P
-1093.33% / 8.65%
Non-scoringIONS / S&P
49.98% / 12.79%
Non-scoringIONS / S&P
22.61 / 21.37
Non-scoringIONS / S&P
7.11 / 3.32
Non-scoringIONS / S&P
IONS unavailable / $3.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.27b
2019-Q12/3 WinIONS / S&P
50.15% / 13.65%
WinIONS / S&P
38.63% / 8.12%
LoseIONS / S&P
-9100.00% / 14.29%
Non-scoringIONS / S&P
47.79% / 12.97%
Non-scoringIONS / S&P
31.52 / 20.86
Non-scoringIONS / S&P
9.38 / 3.26
Non-scoringIONS / S&P
IONS unavailable / $3.08m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $34.35b
2018-Q43/3 WinIONS / S&P
4.81% / -13.52%
WinIONS / S&P
16.63% / 9.05%
WinIONS / S&P
4040.00% / 18.23%
Non-scoringIONS / S&P
45.65% / 13.10%
Non-scoringIONS / S&P
27.24 / 19.39
Non-scoringIONS / S&P
7.11 / 2.94
Non-scoringIONS / S&P
IONS unavailable / $3.00m
Non-scoringIONS / S&P
IONS unavailable / $0.01b
Non-scoringIONS / S&P
IONS unavailable / $0.00b
2018-Q31/3 WinIONS / S&P
23.78% / 7.71%
LoseIONS / S&P
7.97% / 10.21%
LoseIONS / S&P
-167.39% / 19.06%
Non-scoringIONS / S&P
-8.56% / 13.01%
Non-scoringIONS / S&P
IONS unavailable / 22.25
Non-scoringIONS / S&P
9.98 / 3.45
Non-scoringIONS / S&P
IONS unavailable / $3.00m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.17b
2018-Q20/3 LoseIONS / S&P
-5.47% / 3.43%
LoseIONS / S&P
4.33% / 9.03%
LoseIONS / S&P
-155.56% / 14.46%
Non-scoringIONS / S&P
-8.63% / 12.56%
Non-scoringIONS / S&P
IONS unavailable / 22.49
Non-scoringIONS / S&P
8.21 / 3.25
Non-scoringIONS / S&P
IONS unavailable / $3.00m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.19b
2018-Q11/3 LoseIONS / S&P
-12.37% / -0.76%
WinIONS / S&P
20.17% / 7.68%
LoseIONS / S&P
-133.33% / 12.46%
Non-scoringIONS / S&P
-1.85% / 12.27%
Non-scoringIONS / S&P
IONS unavailable / 23.41
Non-scoringIONS / S&P
18.35 / 3.17
Non-scoringIONS / S&P
IONS unavailable / $3.00m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.08b
2017-Q41/3 LoseIONS / S&P
-0.79% / 6.64%
WinIONS / S&P
37.93% / 7.03%
LoseIONS / S&P
-110.00% / 13.82%
Non-scoringIONS / S&P
0.07% / 12.09%
Non-scoringIONS / S&P
18064.11 / 24.25
Non-scoringIONS / S&P
22.37 / 3.23
Non-scoringIONS / S&P
IONS unavailable / $2.92m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.05b
2017-Q31/3 LoseIONS / S&P
-0.33% / 4.48%
WinIONS / S&P
124.05% / 5.68%
LoseIONS / S&P
-130.07% / 17.57%
Non-scoringIONS / S&P
10.38% / 12.04%
Non-scoringIONS / S&P
114.28 / 23.28
Non-scoringIONS / S&P
20.52 / 3.08
Non-scoringIONS / S&P
IONS unavailable / $2.92m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.11b
2017-Q22/3 WinIONS / S&P
26.54% / 3.09%
WinIONS / S&P
198.52% / 4.83%
LoseIONS / S&P
-128.57% / 17.74%
Non-scoringIONS / S&P
12.42% / 11.96%
Non-scoringIONS / S&P
96.79 / 23.40
Non-scoringIONS / S&P
29.30 / 3.03
Non-scoringIONS / S&P
IONS unavailable / $2.92m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.08b
2017-Q11/3 LoseIONS / S&P
-15.95% / 6.07%
WinIONS / S&P
75.08% / 3.67%
LoseIONS / S&P
-107.96% / 13.32%
Non-scoringIONS / S&P
2.54% / 11.75%
Non-scoringIONS / S&P
433.76 / 23.60
Non-scoringIONS / S&P
24.68 / 3.01
Non-scoringIONS / S&P
IONS unavailable / $2.92m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $20.24b
2016-Q42/3 WinIONS / S&P
30.54% / 3.82%
WinIONS / S&P
31.40% / 2.09%
LoseIONS / S&P
IONS unavailable / 7.05%
Non-scoringIONS / S&P
-16.20% / 11.37%
Non-scoringIONS / S&P
IONS unavailable / 23.76
Non-scoringIONS / S&P
58.43 / 2.91
Non-scoringIONS / S&P
IONS unavailable / $2.88m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $1.11b
2016-Q31/3 WinIONS / S&P
57.32% / 3.85%
LoseIONS / S&P
-24.97% / 0.20%
LoseIONS / S&P
IONS unavailable / -3.15%
Non-scoringIONS / S&P
-77.30% / 10.82%
Non-scoringIONS / S&P
IONS unavailable / 24.22
Non-scoringIONS / S&P
31.79 / 2.78
Non-scoringIONS / S&P
IONS unavailable / $2.88m
Non-scoringIONS / S&P
IONS unavailable / $0.00b
Non-scoringIONS / S&P
IONS unavailable / $0.16b

Dividend-reinvested, split-adjusted total return

1Y · 2025-08-29 to 2026-08-27

MetricIONS total returnS&P 500 Total Return Index
Total return46.41%20.78%
Annualized return46.41%20.78%

5Y · 2021-09-01 to 2026-08-27

MetricIONS total returnS&P 500 Total Return Index
Total return54.99%83.14%
Annualized return9.16%12.86%

10Y · 2016-09-01 to 2026-08-27

MetricIONS total returnS&P 500 Total Return Index
Total return107.82%319.30%
Annualized return7.59%15.41%

Calculation rules

window
Latest 40 completed benchmark quarters; unavailable issuer evidence remains visible and scores 0.
return Basis
Issuer adjusted close reinvests distributions and normalizes splits; the S&P 500 Total Return Index is the direct benchmark.
point Rule
Strict same-quarter win = 1. Loss, tie or unavailable evidence = 0. No partial or subjective points.
frequency
Quarter endpoints only.
fundamentals
Trailing-four-quarter issuer revenue and EPS growth use the issuer's normalized government-filed facts.
non Scoring
Net margin, P/E, P/B and other gray context columns never enter the score.

Snapshot captured 2026-09-04.