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State Street(R) SPDR(R) S&P(R) Biotech ETF (XBI) ETF Holdings

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XBI ETF holdings

State Street(R) SPDR(R) S&P(R) Biotech ETF (XBI). Weights reproduce the dated portfolio and may not sum to exactly 100% because of cash, derivatives, rounding, liabilities, or other positions. Provenance stays internal.

  • Fund: Reported value State Street(R) SPDR(R) S&P(R) Biotech ETF.
  • Report date: Reported value 2026-03-31.
  • Reported holdings: Reported value 158.
  • SEC series ID: Reported value S000010018.
Snapshot fieldReported value
FundState Street(R) SPDR(R) S&P(R) Biotech ETF
Report date2026-03-31
Reported holdings158
SEC series IDS000010018

Positions 1–158 of 158

TickerIssuerWeightValue (USD)Balance
State Street Global AdvisorsState Street Global Advisors8.009477343429%595,460,501595,460,501 NS
Apellis Pharmaceuticals IncApellis Pharmaceuticals Inc1.834674850602%136,397,964.423,390,454 NS
Alkermes PLCAlkermes PLC1.451047012575%107,877,348.83,050,830 NS
Madrigal Pharmaceuticals IncMadrigal Pharmaceuticals Inc1.382936341539%102,813,695.76196,408 NS
TG Therapeutics IncTG Therapeutics Inc1.349587581325%100,334,399.223,020,301 NS
Insmed IncInsmed Inc1.336949323513%99,394,814.4607,845 NS
Scholar Rock Holding CorpScholar Rock Holding Corp1.29734161303%96,450,199.41,961,965 NS
Apogee Therapeutics IncApogee Therapeutics Inc1.284317696506%95,481,942.981,134,394 NS
Protagonist Therapeutics IncProtagonist Therapeutics Inc1.244862726598%92,548,683.4878,071 NS
Summit Therapeutics IncSummit Therapeutics Inc1.241085320587%92,267,854.084,866,448 NS
United Therapeutics CorpUnited Therapeutics Corp1.240524758795%92,226,179.4155,530 NS
Praxis Precision Medicines IncPraxis Precision Medicines Inc1.236209206642%91,905,341.88285,252 NS
Arrowhead Pharmaceuticals IncArrowhead Pharmaceuticals Inc1.229809768219%91,429,578.91,458,207 NS
Cogent Biosciences IncCogent Biosciences Inc1.215670570777%90,378,407.492,348,101 NS
Bridgebio Pharma IncBridgebio Pharma Inc1.185467238192%88,132,956.161,186,816 NS
PTC Therapeutics IncPTC Therapeutics Inc1.182233388139%87,892,537.231,290,071 NS
Cytokinetics IncCytokinetics Inc1.180397744345%87,756,067.231,331,453 NS
Alnylam Pharmaceuticals IncAlnylam Pharmaceuticals Inc1.176738374117%87,484,013.22264,406 NS
Exelixis IncExelixis Inc1.170672263831%87,033,031.352,029,215 NS
Nuvalent IncNuvalent Inc1.166883822301%86,751,381.6846,768 NS
Kymera Therapeutics IncKymera Therapeutics Inc1.164331509381%86,561,631.21,039,280 NS
CG oncology IncCG oncology Inc1.162452612886%86,421,945.61,276,920 NS
Natera IncNatera Inc1.159229039318%86,182,290.67430,933 NS
Neurocrine Biosciences IncNeurocrine Biosciences Inc1.158979738929%86,163,756.56654,044 NS
Twist Bioscience CorpTwist Bioscience Corp1.155672354038%85,917,870.721,808,036 NS
Krystal Biotech IncKrystal Biotech Inc1.154541455419%85,833,794.64332,277 NS
Vaxcyte IncVaxcyte Inc1.151120542947%85,579,468.651,472,715 NS
Mirum Pharmaceuticals IncMirum Pharmaceuticals Inc1.147501809221%85,310,435.74923,473 NS
Amicus Therapeutics IncAmicus Therapeutics Inc1.146707566894%85,251,388.25,895,670 NS
Ionis Pharmaceuticals IncIonis Pharmaceuticals Inc1.144266543192%85,069,911.541,132,906 NS
Travere Therapeutics IncTravere Therapeutics Inc1.144206320571%85,065,434.322,863,192 NS
Arcellx IncArcellx Inc1.144091979615%85,056,933.7740,785 NS
Regeneron Pharmaceuticals IncRegeneron Pharmaceuticals Inc1.1369614215%84,526,816109,400 NS
Incyte CorpIncyte Corp1.133084974926%84,238,623.56895,013 NS
Celcuity IncCelcuity Inc1.123713680988%83,541,919.5731,925 NS
Revolution Medicines IncRevolution Medicines Inc1.112889321176%82,737,188850,768 NS
Halozyme Therapeutics IncHalozyme Therapeutics Inc1.107953327473%82,370,224.071,274,489 NS
Rhythm Pharmaceuticals IncRhythm Pharmaceuticals Inc1.100994305542%81,852,859.14941,162 NS
Biogen IncBiogen Inc1.096991426598%81,555,267.15444,855 NS
Arcutis Biotherapeutics IncArcutis Biotherapeutics Inc1.089451105092%80,994,685.83,437,805 NS
AbbVie IncAbbVie Inc1.088563287705%80,928,681.47372,103 NS
Gilead Sciences IncGilead Sciences Inc1.087792715593%80,871,393.68580,264 NS
CRISPR Therapeutics AGCRISPR Therapeutics AG1.0857136091%80,716,823.571,696,801 NS
BioMarin Pharmaceutical IncBioMarin Pharmaceutical Inc1.067273599669%79,345,910.491,404,601 NS
Roivant Sciences LtdRoivant Sciences Ltd1.067185555618%79,339,364.92,864,237 NS
Amgen IncAmgen Inc1.06270836028%79,006,510.1224,546 NS
ImmunityBio IncImmunityBio Inc1.056859394804%78,571,671.7510,244,025 NS
Beam Therapeutics IncBeam Therapeutics Inc1.041297862482%77,414,757.583,248,626 NS
Viking Therapeutics IncViking Therapeutics Inc1.036975450372%77,093,410.062,369,189 NS
Vera Therapeutics IncVera Therapeutics Inc1.034668922449%76,921,932.421,912,054 NS
Moderna IncModerna Inc1.034333236236%76,896,9761,513,720 NS
Vertex Pharmaceuticals IncVertex Pharmaceuticals Inc1.033562958833%76,839,710.12172,078 NS
Erasca IncErasca Inc1.03008927567%76,581,460.924,733,094 NS
ACADIA Pharmaceuticals IncACADIA Pharmaceuticals Inc1.021806743535%75,965,700.33,412,655 NS
Sarepta Therapeutics IncSarepta Therapeutics Inc0.894766695036%66,520,972.83,057,030 NS
Agios Pharmaceuticals IncAgios Pharmaceuticals Inc0.878381998674%65,302,860.921,930,324 NS
Ultragenyx Pharmaceutical IncUltragenyx Pharmaceutical Inc0.87577688601%65,109,185.153,107,837 NS
Disc Medicine IncDisc Medicine Inc0.870412184001%64,710,349.121,012,048 NS
Immunome IncImmunome Inc0.863333927275%64,184,119.742,934,802 NS
Immunovant IncImmunovant Inc0.857529001782%63,752,555.522,566,528 NS
BioCryst Pharmaceuticals IncBioCryst Pharmaceuticals Inc0.852196509154%63,356,114.086,655,054 NS
Veracyte IncVeracyte Inc0.848171879035%63,056,905.011,957,681 NS
Dyne Therapeutics IncDyne Therapeutics Inc0.838290919478%62,322,310.123,437,524 NS
Catalyst Pharmaceuticals IncCatalyst Pharmaceuticals Inc0.755441467217%56,162,909.922,268,292 NS
Syndax Pharmaceuticals IncSyndax Pharmaceuticals Inc0.736260917624%54,736,941.762,343,191 NS
Denali Therapeutics IncDenali Therapeutics Inc0.731088443313%54,352,396.82,830,854 NS
Ideaya Biosciences IncIdeaya Biosciences Inc0.729968703558%54,269,150.321,628,726 NS
Spyre Therapeutics IncSpyre Therapeutics Inc0.725654386735%53,948,404.641,069,556 NS
GRAIL IncGRAIL Inc0.723848213316%53,814,125.61,041,295 NS
Viridian Therapeutics IncViridian Therapeutics Inc0.701688283238%52,166,656.922,667,007 NS
Recursion Pharmaceuticals IncRecursion Pharmaceuticals Inc0.690956510652%51,368,808.7716,732,511 NS
Kodiak Sciences IncKodiak Sciences Inc0.689210952217%51,239,036.121,344,151 NS
Soleno Therapeutics IncSoleno Therapeutics Inc0.673737785423%50,088,691.441,496,078 NS
Dianthus Therapeutics IncDianthus Therapeutics Inc0.662236014539%49,233,598.16586,673 NS
Intellia Therapeutics IncIntellia Therapeutics Inc0.64722657519%48,117,729.063,753,333 NS
Mineralys Therapeutics IncMineralys Therapeutics Inc0.646144575152%48,037,288.321,773,248 NS
Arcus Biosciences IncArcus Biosciences Inc0.628542093301%46,728,640.82,163,363 NS
Ardelyx IncArdelyx Inc0.617531226322%45,910,043.527,664,448 NS
ADMA Biologics IncADMA Biologics Inc0.595793843771%44,293,988.924,916,092 NS
Nurix Therapeutics IncNurix Therapeutics Inc0.58582813644%43,553,093.52,809,877 NS
Tango Therapeutics IncTango Therapeutics Inc0.555067172071%41,266,185.321,972,571 NS
Celldex Therapeutics IncCelldex Therapeutics Inc0.521586281283%38,777,065.61,222,480 NS
Novavax IncNovavax Inc0.511069489662%37,995,200.14,667,715 NS
Oruka Therapeutics IncOruka Therapeutics Inc0.502104044366%37,328,668.65761,033 NS
Olema Pharmaceuticals IncOlema Pharmaceuticals Inc0.495742405921%36,855,715.892,471,879 NS
Stoke Therapeutics IncStoke Therapeutics Inc0.493000634843%36,651,880.321,125,672 NS
Vericel CorpVericel Corp0.483019350567%35,909,826.841,116,252 NS
Capricor Therapeutics IncCapricor Therapeutics Inc0.479195943567%35,625,577.61,171,894 NS
Palvella Therapeutics IncPalvella Therapeutics Inc0.459792234999%34,183,018.8274,232 NS
Biohaven LtdBiohaven Ltd0.437503977991%32,526,009.723,844,682 NS
Monte Rosa Therapeutics IncMonte Rosa Therapeutics Inc0.435173142551%32,352,724.951,966,731 NS
Corvus Pharmaceuticals IncCorvus Pharmaceuticals Inc0.416569310217%30,969,632.542,116,858 NS
Iovance Biotherapeutics IncIovance Biotherapeutics Inc0.38430493744%28,570,954.238,139,873 NS
AnaptysBio IncAnaptysBio Inc0.382075737509%28,405,225.5512,175 NS
Relay Therapeutics IncRelay Therapeutics Inc0.378976416324%28,174,808.052,831,639 NS
uniQure NVuniQure NV0.373296299948%27,752,522.71,697,402 NS
ORIC Pharmaceuticals IncORIC Pharmaceuticals Inc0.37007527223%27,513,057.042,171,512 NS
MannKind CorpMannKind Corp0.360315337112%26,787,459.6510,933,657 NS
CareDx IncCareDx Inc0.345689023537%25,700,073.841,480,419 NS
Taysha Gene Therapies IncTaysha Gene Therapies Inc0.339042375265%25,205,932.175,638,911 NS
Tyra Biosciences IncTyra Biosciences Inc0.337671337932%25,104,003.1655,457 NS
Geron CorpGeron Corp0.332968897519%24,754,402.5716,613,693 NS
Day One Biopharmaceuticals IncDay One Biopharmaceuticals Inc0.321090611169%23,871,317.441,113,401 NS
Precigen IncPrecigen Inc0.312579359458%23,238,552.786,004,794 NS
Vir Biotechnology IncVir Biotechnology Inc0.304649927335%22,649,043.22,527,795 NS
KalVista Pharmaceuticals IncKalVista Pharmaceuticals Inc0.291873332168%21,699,173.761,077,952 NS
CytomX Therapeutics IncCytomX Therapeutics Inc0.285184140191%21,201,869.24,511,036 NS
Annexon IncAnnexon Inc0.284909600945%21,181,458.723,823,368 NS
Kura Oncology IncKura Oncology Inc0.275929798566%20,513,859.92,523,230 NS
Inhibrx Biosciences IncInhibrx Biosciences Inc0.268199309366%19,939,140.63296,581 NS
SELLAS Life Sciences Group IncSELLAS Life Sciences Group Inc0.266837482401%19,837,896.34,689,810 NS
Janux Therapeutics IncJanux Therapeutics Inc0.266342619897%19,801,1061,424,540 NS
Compass Therapeutics IncCompass Therapeutics Inc0.262206278471%19,493,591.813,684,989 NS
Savara IncSavara Inc0.261083725731%19,410,136.23,554,970 NS
Rigel Pharmaceuticals IncRigel Pharmaceuticals Inc0.257790500328%19,165,303.04708,776 NS
Sana Biotechnology IncSana Biotechnology Inc0.257629963345%19,153,3686,650,475 NS
Cullinan Therapeutics IncCullinan Therapeutics Inc0.249904478955%18,579,020.811,307,461 NS
ARS Pharmaceuticals IncARS Pharmaceuticals Inc0.239082323341%17,774,453.182,213,506 NS
Zenas Biopharma IncZenas Biopharma Inc0.238313363453%17,717,285.25906,255 NS
Xencor IncXencor Inc0.230700163377%17,151,285.781,422,163 NS
Replimune Group IncReplimune Group Inc0.226212502165%16,817,652.92,198,386 NS
Sionna Therapeutics IncSionna Therapeutics Inc0.224666238261%16,702,696.7416,630 NS
Vor BioPharma IncVor BioPharma Inc0.223742421299%16,634,016932,400 NS
ArriVent Biopharma IncArriVent Biopharma Inc0.217556141111%16,174,100.16701,088 NS
Ironwood Pharmaceuticals IncIronwood Pharmaceuticals Inc0.188813944533%14,037,276.243,999,224 NS
Bicara Therapeutics IncBicara Therapeutics Inc0.187716392166%13,955,679.27701,643 NS
Prime Medicine IncPrime Medicine Inc0.186299963977%13,850,375.643,979,993 NS
Altimmune IncAltimmune Inc0.180343162533%13,407,520.284,353,091 NS
Absci CorpAbsci Corp0.179507037613%13,345,3594,448,453 NS
Emergent BioSolutions IncEmergent BioSolutions Inc0.17560518149%13,055,277.51,572,925 NS
Allogene Therapeutics IncAllogene Therapeutics Inc0.171078701261%12,718,758.645,212,606 NS
Hyperliquid Strategies IncHyperliquid Strategies Inc0.167830869405%12,477,300.242,451,336 NS
4D Molecular Therapeutics Inc4D Molecular Therapeutics Inc0.165058812424%12,271,213.081,318,068 NS
Vanda Pharmaceuticals IncVanda Pharmaceuticals Inc0.158382340824%11,774,854.211,704,031 NS
REGENXBIO IncREGENXBIO Inc0.153726630439%11,428,727.81,363,810 NS
Lexeo Therapeutics IncLexeo Therapeutics Inc0.143816149797%10,691,938.181,862,707 NS
Verastem IncVerastem Inc0.143613128965%10,676,844.72,014,499 NS
Arbutus Biopharma CorpArbutus Biopharma Corp0.137283780203%10,206,292.52,268,065 NS
Myriad Genetics IncMyriad Genetics Inc0.13076214012%9,721,444.52,160,321 NS
Prothena Corp PLCProthena Corp PLC0.12857865696%9,559,114.56983,448 NS
Ocugen IncOcugen Inc0.127155388453%9,453,302.395,222,819 NS
Rocket Pharmaceuticals IncRocket Pharmaceuticals Inc0.12553715378%9,332,995.562,606,982 NS
MiMedx Group IncMiMedx Group Inc0.121280099036%9,016,5072,282,660 NS
Akebia Therapeutics IncAkebia Therapeutics Inc0.112909590642%8,394,205.836,038,997 NS
Anavex Life Sciences CorpAnavex Life Sciences Corp0.109590110973%8,147,420.812,653,883 NS
CONTRA METSERA INCCONTRA METSERA INC0.100888427528%7,500,498.61,530,714 NS
Invivyd IncInvivyd Inc0.098877705525%7,351,012.55,654,625 NS
Perspective Therapeutics IncPerspective Therapeutics Inc0.096110340351%7,145,274.151,713,495 NS
State Street Global AdvisorsState Street Global Advisors0.063221826087%4,700,194.364,700,194.36 NS
Damora Therapeutics IncDamora Therapeutics Inc0.03267683092%2,429,342.393,797 NS
CONTRA AKERO THERAPEUTCONTRA AKERO THERAPEUT0.017783211185%1,322,083.752,033,975 NS
CONTRA INHIBRX INCCONTRA INHIBRX INC0.014390877697%1,069,882.451,645,973 NS
CONTRA MIRATI THERAPEUCONTRA MIRATI THERAPEU0.012895191179%958,686.41,369,552 NS
CONTRA VERVE THERAPEUTCONTRA VERVE THERAPEUT0.00762897152%567,171.99900,273 NS
CONTRA BLUEPRINT MEDICCONTRA BLUEPRINT MEDIC0.004680585531%347,975.74756,469 NS
State Street Global AdvisorsState Street Global Advisors0.000491637382%36,550.5336,550.53 NS
OMNIAB INCOMNIAB INC0%0161,959 NS
OMNIAB INCOMNIAB INC0%0161,959 NS

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