| BlackRock Funds III | BlackRock Funds III | 9.662015% | 784,812,698.34 | 784,655,767.188 NS |
|---|
| GILD | Gilead Sciences, Inc. | 7.748127% | 629,354,084.59 | 4,515,707 NS |
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| AMGN | Amgen, Inc. | 7.507492% | 609,808,123.8 | 1,733,148 NS |
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| VRTX | Vertex Pharmaceuticals, Inc. | 7.443742% | 604,629,895.82 | 1,354,033 NS |
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| REGN | Regeneron Pharmaceuticals, Inc. | 7.21242% | 585,840,372.48 | 758,232 NS |
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| ALNY | Alnylam Pharmaceuticals, Inc. | 3.990492% | 324,134,148.54 | 979,642 NS |
|---|
| INSM | Insmed, Inc. | 3.196629% | 259,651,282.24 | 1,587,887 NS |
|---|
| ARGX | Argenx SE | 3.073624% | 249,660,060.75 | 341,883 NS |
|---|
| BIIB | Biogen, Inc. | 2.462512% | 200,021,463.18 | 1,091,046 NS |
|---|
| NTRA | Natera, Inc. | 2.414413% | 196,114,593.78 | 980,622 NS |
|---|
| UTHR | United Therapeutics Corp. | 2.303316% | 187,090,526.82 | 315,509 NS |
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| BeOne Medicines Ltd. | BeOne Medicines Ltd. | 1.934583% | 157,139,596.71 | 529,143 NS |
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| INCY | Incyte Corp. | 1.700932% | 138,160,912.76 | 1,467,923 NS |
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| MRNA | Moderna, Inc. | 1.683893% | 136,776,917.2 | 2,692,459 NS |
|---|
| ILMN | Illumina, Inc. | 1.680295% | 136,484,688.66 | 1,107,291 NS |
|---|
| Revolution Medicines, Inc. | Revolution Medicines, Inc. | 1.537187% | 124,860,442 | 1,283,912 NS |
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| ROIV | Roivant Sciences Ltd. | 1.242189% | 100,898,828.9 | 3,642,557 NS |
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| NBIX | Neurocrine Biosciences, Inc. | 1.179923% | 95,841,113.48 | 727,502 NS |
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| Genmab A/S | Genmab A/S | 1.174286% | 95,383,279.34 | 3,555,098 NS |
|---|
| BBIO | Bridgebio Pharma, Inc. | 1.132448% | 91,984,896.62 | 1,238,687 NS |
|---|
| IONS | Ionis Pharmaceuticals, Inc. | 1.114471% | 90,524,674.41 | 1,205,549 NS |
|---|
| MEDP | Medpace Holdings, Inc. | 1.004533% | 81,594,845.18 | 169,922 NS |
|---|
| MDGL | Madrigal Pharmaceuticals, Inc. | 1.001105% | 81,316,353.27 | 155,341 NS |
|---|
| EXEL | Exelixis, Inc. | 0.988114% | 80,261,172.14 | 1,871,326 NS |
|---|
| BMRN | BioMarin Pharmaceutical, Inc. | 0.982222% | 79,782,521.7 | 1,412,330 NS |
|---|
| ASND | Ascendis Pharma A/S | 0.957276% | 77,756,306.04 | 339,948 NS |
|---|
| PRAX | Praxis Precision Medicines, Inc. | 0.773863% | 62,858,302.43 | 195,097 NS |
|---|
| CRL | Charles River Laboratories International, Inc. | 0.769126% | 62,473,462.5 | 362,165 NS |
|---|
| ARWR | Arrowhead Pharmaceuticals, Inc. | 0.752752% | 61,143,472.5 | 975,175 NS |
|---|
| PCVX | Vaxcyte, Inc. | 0.748096% | 60,765,336.45 | 1,045,695 NS |
|---|
| TECH | Bio-Techne Corp. | 0.741148% | 60,200,907 | 1,151,950 NS |
|---|
| CYTK | Cytokinetics, Inc. | 0.727833% | 59,119,424.52 | 896,972 NS |
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| HALO | Halozyme Therapeutics, Inc. | 0.691046% | 56,131,284.26 | 868,502 NS |
|---|
| AXSM | Axsome Therapeutics, Inc. | 0.663973% | 53,932,253.76 | 319,088 NS |
|---|
| BNTX | BioNTech SE | 0.655993% | 53,284,093.28 | 599,506 NS |
|---|
| KRYS | Krystal Biotech, Inc. | 0.600957% | 48,813,697.12 | 188,966 NS |
|---|
| PTGX | Protagonist Therapeutics, Inc. | 0.58009% | 47,118,753.8 | 447,047 NS |
|---|
| RGEN | Repligen Corp. | 0.575702% | 46,762,286.72 | 396,896 NS |
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| KYMR | Kymera Therapeutics, Inc. | 0.53463% | 43,426,156.65 | 521,385 NS |
|---|
| ALKS | Alkermes plc | 0.529644% | 43,021,168.32 | 1,216,662 NS |
|---|
| RYTM | Rhythm Pharmaceuticals, Inc. | 0.508093% | 41,270,656.83 | 474,539 NS |
|---|
| Abivax SA | Abivax SA | 0.503736% | 40,916,782.35 | 367,461 NS |
|---|
| PTCT | PTC Therapeutics, Inc. | 0.497515% | 40,411,445.76 | 593,152 NS |
|---|
| COGT | Cogent Biosciences, Inc. | 0.478312% | 38,851,652.04 | 1,009,396 NS |
|---|
| Arcellx, Inc. | Arcellx, Inc. | 0.474699% | 38,558,163.48 | 335,814 NS |
|---|
| Terns Pharmaceuticals, Inc. | Terns Pharmaceuticals, Inc. | 0.463322% | 37,634,066.56 | 713,848 NS |
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| Nuvalent, Inc. | Nuvalent, Inc. | 0.448363% | 36,419,028.45 | 355,481 NS |
|---|
| MIRM | Mirum Pharmaceuticals, Inc. | 0.446596% | 36,275,501.26 | 392,677 NS |
|---|
| TEM | Tempus AI, Inc. | 0.430844% | 34,996,029.32 | 773,906 NS |
|---|
| XENE | Xenon Pharmaceuticals, Inc. | 0.428386% | 34,796,378.5 | 598,390 NS |
|---|
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 0.410822% | 33,369,703.5 | 2,307,725 NS |
|---|
| CRSP | CRISPR Therapeutics AG | 0.388712% | 31,573,778.81 | 663,733 NS |
|---|
| Apellis Pharmaceuticals, Inc. | Apellis Pharmaceuticals, Inc. | 0.38545% | 31,308,796.35 | 778,245 NS |
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| APGE | Apogee Therapeutics, Inc. | 0.36633% | 29,755,778.4 | 353,520 NS |
|---|
| SRRK | Scholar Rock Holding Corp. | 0.359338% | 29,187,766.8 | 593,730 NS |
|---|
| ACAD | ACADIA Pharmaceuticals, Inc. | 0.3429% | 27,852,624.66 | 1,251,241 NS |
|---|
| Bruker Corp. | Bruker Corp. | 0.339889% | 27,608,033.04 | 764,342 NS |
|---|
| CRNX | Crinetics Pharmaceuticals, Inc. | 0.324818% | 26,383,864.96 | 726,428 NS |
|---|
| CGON | CG oncology, Inc. | 0.316038% | 25,670,685.6 | 379,295 NS |
|---|
| SYRE | Spyre Therapeutics, Inc. | 0.297392% | 24,156,169.96 | 478,909 NS |
|---|
| ERAS | Erasca, Inc. | 0.275766% | 22,399,575.82 | 1,384,399 NS |
|---|
| TARS | Tarsus Pharmaceuticals, Inc. | 0.25695% | 20,871,168.3 | 297,522 NS |
|---|
| TWST | Twist Bioscience Corp. | 0.255538% | 20,756,498.4 | 436,795 NS |
|---|
| Centessa Pharmaceuticals plc | Centessa Pharmaceuticals plc | 0.254654% | 20,684,666.64 | 520,762 NS |
|---|
| IDYA | Ideaya Biosciences, Inc. | 0.25254% | 20,512,991.52 | 615,636 NS |
|---|
| DNLI | Denali Therapeutics, Inc. | 0.249426% | 20,260,032 | 1,055,210 NS |
|---|
| TVTX | Travere Therapeutics, Inc. | 0.246746% | 20,042,366 | 674,600 NS |
|---|
| IBRX | ImmunityBio, Inc. | 0.242933% | 19,732,616.67 | 2,572,701 NS |
|---|
| ARQT | Arcutis Biotherapeutics, Inc. | 0.236329% | 19,196,193.24 | 814,779 NS |
|---|
| VCYT | Veracyte, Inc. | 0.229736% | 18,660,638.03 | 579,343 NS |
|---|
| GPCR | Structure Therapeutics, Inc. | 0.226487% | 18,396,783.2 | 381,676 NS |
|---|
| EWTX | Edgewise Therapeutics, Inc. | 0.221898% | 18,024,048 | 572,192 NS |
|---|
| TXG | 10X Genomics, Inc. | 0.219997% | 17,869,630.68 | 841,716 NS |
|---|
| LEGN | Legend Biotech Corp. | 0.219131% | 17,799,257.52 | 983,928 NS |
|---|
| Newamsterdam Pharma Co. NV | Newamsterdam Pharma Co. NV | 0.211931% | 17,214,465.84 | 537,784 NS |
|---|
| VERA | Vera Therapeutics, Inc. | 0.207908% | 16,887,668.94 | 419,778 NS |
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| DYN | Dyne Therapeutics, Inc. | 0.204782% | 16,633,731.1 | 917,470 NS |
|---|
| BEAM | Beam Therapeutics, Inc. | 0.203053% | 16,493,314.92 | 692,124 NS |
|---|
| BCRX | BioCryst Pharmaceuticals, Inc. | 0.2011% | 16,334,663.52 | 1,715,826 NS |
|---|
| KOD | Kodiak Sciences, Inc. | 0.198249% | 16,103,069.72 | 422,431 NS |
|---|
| SRPT | Sarepta Therapeutics, Inc. | 0.198135% | 16,093,848.32 | 739,607 NS |
|---|
| CAI | Caris Life Sciences, Inc. | 0.197675% | 16,056,436.68 | 898,011 NS |
|---|
| IMVT | Immunovant, Inc. | 0.191502% | 15,555,081.24 | 626,211 NS |
|---|
| ADMA | ADMA Biologics, Inc. | 0.189818% | 15,418,263.39 | 1,711,239 NS |
|---|
| ADPT | Adaptive Biotechnologies Corp. | 0.188993% | 15,351,238.36 | 1,105,997 NS |
|---|
| SMMT | Summit Therapeutics, Inc. | 0.186615% | 15,158,083.92 | 799,477 NS |
|---|
| ORKA | Oruka Therapeutics, Inc. | 0.183775% | 14,927,435.55 | 304,331 NS |
|---|
| SNDX | Syndax Pharmaceuticals, Inc. | 0.18162% | 14,752,400.64 | 631,524 NS |
|---|
| TNGX | Tango Therapeutics, Inc. | 0.177166% | 14,390,554.2 | 687,885 NS |
|---|
| RARE | Ultragenyx Pharmaceutical, Inc. | 0.17546% | 14,251,991.7 | 680,286 NS |
|---|
| IRON | Disc Medicine, Inc. | 0.169156% | 13,740,002.66 | 214,889 NS |
|---|
| AGIO | Agios Pharmaceuticals, Inc. | 0.166632% | 13,534,943.21 | 400,087 NS |
|---|
| GRAL | GRAIL, Inc. | 0.166089% | 13,490,805.6 | 261,045 NS |
|---|
| DFTX | Definium Therapeutics, Inc. | 0.163583% | 13,287,267 | 703,030 NS |
|---|
| ZYME | Zymeworks, Inc. | 0.163379% | 13,270,724.24 | 529,981 NS |
|---|
| RCUS | Arcus Biosciences, Inc. | 0.162839% | 13,226,868 | 612,355 NS |
|---|
| BlackRock Funds III | BlackRock Funds III | 0.159999% | 12,996,156.43 | 12,996,156.43 NS |
|---|
| AUPH | Aurinia Pharmaceuticals, Inc. | 0.159525% | 12,957,659.52 | 874,336 NS |
|---|
| ELVN | Enliven Therapeutics, Inc. | 0.155666% | 12,644,195.2 | 322,556 NS |
|---|
| Day One Biopharmaceuticals, Inc. | Day One Biopharmaceuticals, Inc. | 0.152769% | 12,408,893.12 | 578,773 NS |
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