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CYTOKINETICS, INCORPORATED (CYTK) Forms 3, 4 and 5: Stock Options

CYTOKINETICS, INCORPORATED Forms 3, 4 and 5: Stock Options

Statements of beneficial ownership filed with the SEC by officers, directors and 10% owners: 65 rows in 2026. Transaction codes are the SEC's. Shares and prices are split-adjusted; the as-filed figure is underneath.

  • 2026-09-22: Reporting owner Malik Fady Ibraham; Form 4; Security Non-Qualified Stock Option (Right to Buy); Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
  • 2026-09-14: Reporting owner Blum Robert I; Form 4; Security Non-Qualified Stock Option (Right to Buy); Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
  • 2026-09-08: Reporting owner Malik Fady Ibraham; Form 4; Security Non-Qualified Stock Option (Right to Buy); Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.
  • 2026-08-31: Reporting owner Callos Andrew; Form 4; Security Non-Qualified Stock Option (Right to Buy); Transaction M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3.

CYTK insiders transactions against the stock price

Blue: Split-adjusted close · Orange: Cumulative dividend-reinvested close

$51.00$57.34$64.47$72.48$81.49$91.622025-11-062026-11-06$25.54$34.41$46.37$62.48$84.20$113.462021-11-082026-11-06$5.61$10.24$18.69$34.09$62.19$113.462016-11-072026-11-06$2.92$6.07$12.61$26.23$54.56$113.462006-11-062026-11-06$2.92$6.07$12.61$26.23$54.56$113.462004-04-302026-11-062006-02-08: 3 option exercises at $45.72 close — Sabry James H2006-02-15: 5 option exercises at $43.20 close — MORGANS DAVID J JR, Blum Robert I2006-02-28: 1 option exercise at $42.84 close — Blum Robert I2006-03-01: 14 award or grants at $42.90 close — MORGANS DAVID J JR, WOLFF ANDREW A, TRAUTMAN JAY K and 4 more2006-03-01: 2 option exercises at $42.90 close — Sabry James H2006-03-15: 1 award or grant at $42.24 close — Morgan Bradley Paul2006-03-15: 2 option exercises at $42.24 close — Blum Robert I, MORGANS DAVID J JR2006-03-30: 1 option exercise at $43.14 close — Blum Robert I2006-04-03: 16 option exercises at $46.02 close — Sabry James H2006-04-17: 2 option exercises at $45.06 close — MORGANS DAVID J JR, Blum Robert I2006-05-01: 2 option exercises at $43.02 close — Sabry James H, Blum Robert I2006-05-15: 2 option exercises at $42.18 close — MORGANS DAVID J JR, Blum Robert I2006-05-25: 6 award or grants at $43.74 close — HEIDRICH A GRANT III, SCHMERTZLER MICHAEL, DOW STEPHEN M and 3 more2006-05-30: 1 option exercise at $42.42 close — Blum Robert I2006-06-01: 1 option exercise at $42.66 close — Sabry James H2006-06-15: 3 option exercises at $42.30 close — Blum Robert I, MORGANS DAVID J JR2006-06-30: 1 option exercise at $37.74 close — Blum Robert I2006-07-03: 1 option exercise at $38.94 close — Sabry James H2006-07-17: 1 option exercise at $32.88 close — Blum Robert I2006-07-25: 2 option exercises at $6.00 filed · Value $9.06K — MORGANS DAVID J JR2006-07-26: 2 option exercises at $6.00 filed · Value $20.94K — MORGANS DAVID J JR2006-07-31: 1 option exercise at $34.92 close — Blum Robert I2006-08-01: 1 option exercise at $35.28 close — Sabry James H2006-08-15: 1 option exercise at $33.54 close — Blum Robert I2006-08-18: 1 option exercise at $36.36 close — MORGANS DAVID J JR2006-08-30: 1 option exercise at $40.20 close — Blum Robert I2006-09-01: 1 option exercise at $40.56 close — Sabry James H2006-09-15: 2 option exercises at $41.10 close — Blum Robert I, MORGANS DAVID J JR2006-10-02: 2 option exercises at $38.10 close — Sabry James H, Blum Robert I2006-10-13: 1 option exercise at $41.16 close — MORGANS DAVID J JR2006-10-16: 1 option exercise at $40.20 close — Blum Robert I2006-10-30: 1 option exercise at $44.16 close — Blum Robert I2006-11-01: 1 option exercise at $43.74 close — Sabry James H2006-11-15: 2 option exercises at $46.14 close — MORGANS DAVID J JR, Blum Robert I2006-11-30: 1 option exercise at $45.18 close — Blum Robert I2006-12-01: 2 option exercises at $44.64 close — Sabry James H2006-12-15: 2 option exercises at $40.98 close — Blum Robert I, MORGANS DAVID J JR2007-01-03: 1 option exercise at $50.04 close — Sabry James H2007-01-16: 1 option exercise at $50.04 close — MORGANS DAVID J JR2007-02-01: 1 option exercise at $47.22 close — Sabry James H2007-03-14: 16 award or grants at $40.86 close — Morgan Bradley Paul, Blum Robert I, Cragg David and 5 more2007-05-24: 12 award or grants at $39.30 close — SCHMERTZLER MICHAEL, HEIDRICH A GRANT III, SPUDICH JAMES A and 3 more2007-06-11: 2 option exercises at $39.24 close — Sabry James H2007-06-15: 2 option exercises at $38.94 close — MORGANS DAVID J JR2007-07-02: 1 option exercise at $34.32 close — Sabry James H2007-07-16: 1 option exercise at $32.28 close — Blum Robert I2007-07-31: 1 option exercise at $30.00 close — Blum Robert I2007-08-01: 1 option exercise at $31.14 close — Sabry James H2007-08-10: 2 option exercises at $30.78 close — TRAUTMAN JAY K2007-08-15: 1 option exercise at $27.48 close — Blum Robert I2007-08-30: 2 option exercises at $30.36 close — Blum Robert I2007-09-14: 1 option exercise at $29.10 close — MORGANS DAVID J JR2007-09-28: 1 option exercise at $30.72 close — Blum Robert I2007-10-01: 1 option exercise at $31.50 close — Sabry James H2007-10-15: 1 option exercise at $36.00 close — Blum Robert I2007-10-31: 1 option exercise at $29.70 close — Blum Robert I2007-11-01: 1 option exercise at $31.14 close — Sabry James H2007-11-15: 1 option exercise at $30.72 close — Blum Robert I2007-11-30: 1 option exercise at $29.16 close — Blum Robert I2007-12-03: 1 option exercise at $31.02 close — Sabry James H2007-12-14: 1 option exercise at $29.88 close — Blum Robert I2008-02-29: 14 award or grants at $20.22 close — Morgan Bradley Paul, WOLFF ANDREW A, TRAUTMAN JAY K and 4 more2008-03-31: 2 award or grants at $19.92 close — RABSON MICHAEL2008-05-14: 1 award or grant at $23.22 close — GILBERT DENISE2008-05-22: 6 award or grants at $22.98 close — SCHMERTZLER MICHAEL, SPUDICH JAMES A, MCDADE MARK and 3 more2008-07-01: 4 award or grants at $22.38 close — SCHMERTZLER MICHAEL, SPUDICH JAMES A, DOW STEPHEN M and 1 more2008-07-31: 1 option exercise at $31.68 close — Blum Robert I2008-08-15: 1 option exercise at $29.34 close — Blum Robert I2008-08-29: 1 option exercise at $31.20 close — Blum Robert I2008-09-15: 1 option exercise at $28.20 close — Blum Robert I2009-01-02: 5 award or grants at $1.14 filed · Value $70.00K — SPUDICH JAMES A, SCHMERTZLER MICHAEL, HEIDRICH A GRANT III and 1 more2009-02-19: 1 award or grant at $11.70 close — HENDERSON JOHN T2009-02-26: 16 award or grants at $11.10 close — Morgan Bradley Paul, WOLFF ANDREW A, RABSON MICHAEL and 4 more2009-03-16: 1 option exercise at $10.50 close — Blum Robert I2009-03-17: 1 option exercise at $12.00 close — Blum Robert I2009-03-26: 1 option exercise at $11.64 close — Blum Robert I2009-03-30: 1 option exercise at $10.44 close — Blum Robert I2009-04-01: 2 award or grants at $0.70 filed · Value $22.50K — DOW STEPHEN M, HENDERSON JOHN T2009-04-21: 1 option exercise at $12.00 close — Blum Robert I2009-04-22: 1 option exercise at $12.18 close — Blum Robert I2009-04-24: 1 option exercise at $12.00 close — Blum Robert I2009-05-01: 1 option exercise at $11.70 close — Blum Robert I2009-05-06: 1 option exercise at $11.40 close — Blum Robert I2009-05-18: 1 option exercise at $11.82 close — Blum Robert I2009-05-21: 7 award or grants at $11.10 close — SCHMERTZLER MICHAEL, SPUDICH JAMES A, MCDADE MARK and 4 more2009-05-22: 1 option exercise at $12.48 close — Blum Robert I2009-06-08: 1 option exercise at $18.12 close — Blum Robert I2009-06-22: 1 option exercise at $15.60 close — Blum Robert I2009-07-08: 1 option exercise at $16.38 close — Blum Robert I2009-07-22: 1 option exercise at $16.80 close — Blum Robert I2009-08-04: 1 option exercise at $18.36 close — Blum Robert I2009-08-17: 1 option exercise at $16.68 close — Sabry James H2009-08-18: 1 option exercise at $16.86 close — Blum Robert I2009-08-19: 1 option exercise at $16.86 close — Sabry James H2009-08-20: 1 option exercise at $17.16 close — Sabry James H2009-09-10: 1 option exercise at $20.10 close — Blum Robert I2009-09-24: 1 option exercise at $26.88 close — Blum Robert I2009-10-08: 1 option exercise at $29.34 close — Blum Robert I2009-10-22: 1 option exercise at $28.80 close — Blum Robert I2009-11-05: 1 award or grant at $19.98 close — GAGE L PATRICK2009-11-10: 1 option exercise at $18.90 close — Blum Robert I2009-11-13: 1 option exercise at $20.10 close — Sabry James H2009-11-16: 3 option exercises at $20.40 close — BARBARI SHARON SURREY, Sabry James H2009-11-17: 2 option exercises at $20.76 close — Sabry James H2009-11-24: 1 option exercise at $20.46 close — Blum Robert I2009-12-01: 1 option exercise at $18.84 close — Blum Robert I2009-12-02: 1 option exercise at $18.84 close — Sabry James H2009-12-15: 3 option exercises at $18.06 close — Sabry James H, Blum Robert I2009-12-16: 1 option exercise at $18.00 close — Sabry James H2009-12-18: 1 option exercise at $15.84 close — RABSON MICHAEL2010-01-04: 5 award or grants at $1.24 filed · Value $99.68K — SCHMERTZLER MICHAEL, DOW STEPHEN M, SPUDICH JAMES A and 2 more2010-01-05: 1 option exercise at $18.84 close — Blum Robert I2010-01-19: 1 option exercise at $19.62 close — Blum Robert I2010-02-11: 1 option exercise at $18.18 close — Blum Robert I2010-02-18: 1 option exercise at $18.90 close — Blum Robert I2010-02-24: 13 award or grants at $18.48 close — Morgan Bradley Paul, WOLFF ANDREW A, MORGANS DAVID J JR and 3 more2010-03-31: 1 option exercise at $19.20 close — Sabry James H2010-04-26: 1 option exercise at $19.08 close — Sabry James H2010-05-12: 1 option exercise at $18.12 close — Sabry James H2010-05-18: 1 option exercise at $17.94 close — Sabry James H2010-05-20: 7 award or grants at $16.86 close — SCHMERTZLER MICHAEL, HEIDRICH A GRANT III, DOW STEPHEN M and 4 more2010-06-03: 1 option exercise at $17.94 close — Sabry James H2010-11-01: 1 award or grant at $15.24 close — COSTA SANTO J2011-01-03: 5 award or grants at $0.86 filed · Value $119.44K — HEIDRICH A GRANT III, DOW STEPHEN M, GAGE L PATRICK and 2 more2011-02-09: 1 award or grant at $11.04 close — WIERENGA WENDALL2011-02-28: 12 award or grants at $9.42 close — Morgan Bradley Paul, WOLFF ANDREW A, MORGANS DAVID J JR and 3 more2011-05-18: 6 award or grants at $8.64 close — WIERENGA WENDALL, SPUDICH JAMES A, HENDERSON JOHN T and 3 more2012-01-03: 3 award or grants at $0.39 filed · Value $79.59K — DOW STEPHEN M, HENDERSON JOHN T, GAGE L PATRICK2012-03-05: 11 award or grants at $6.30 close — Morgan Bradley Paul, WOLFF ANDREW A, Cragg David and 3 more2012-04-02: 1 award or grant at $0.46 filed · Value $7.57K — SMITH SANDFORD D2012-05-22: 7 award or grants at $5.46 close — DOW STEPHEN M, WIERENGA WENDALL, SMITH SANDFORD D and 4 more2013-01-02: 4 award or grants at $0.27 filed · Value $148.56K — DOW STEPHEN M, SMITH SANDFORD D, HENDERSON JOHN T and 1 more2013-02-07: 1 award or grant at $6.60 close — PARSHALL B LYNNE2013-03-05: 12 award or grants at $6.00 close — Morgan Bradley Paul, WOLFF ANDREW A, Malik Fady Ibraham and 3 more2013-04-01: 1 award or grant at $0.46 filed · Value $13.24K — PARSHALL B LYNNE2013-05-22: 7 award or grants at $6.78 close — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 4 more2014-01-02: 5 award or grants at $2.69 filed · Value $165.11K — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 2 more2014-01-31: 2 award or grants at $7.75 close — CHARPENTIER BONNIE2014-02-24: 10 award or grants at $9.65 close — Morgan Bradley Paul, Malik Fady Ibraham, Cragg David and 2 more2014-05-21: 7 award or grants at $4.44 close — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 4 more2015-01-02: 4 award or grants at $2.95 filed · Value $87.56K — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 1 more2015-02-26: 14 award or grants at $7.96 close — Morgan Bradley Paul, WOLFF ANDREW A, Malik Fady Ibraham and 4 more2015-03-11: 2 option exercises at $7.91 close — WOLFF ANDREW A2015-05-20: 7 award or grants at $6.21 close — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 4 more2015-05-20: 1 other transaction at $6.21 close — GILBERT DENISE2016-01-04: 5 award or grants at $4.00 filed · Value $147.50K — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 2 more2016-02-23: 14 award or grants at $6.67 close — Cragg David, CHARPENTIER BONNIE, Morgan Bradley Paul and 4 more2016-05-18: 7 award or grants at $7.61 close — Kaye Edward M. MD, WIERENGA WENDALL, SMITH SANDFORD D and 4 more2016-07-01: 1 award or grant at $3.86 filed · Value $19.98K — Kaye Edward M. MD2017-01-03: 5 award or grants at $4.96 filed · Value $139.99K — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 2 more2017-02-28: 16 award or grants at $10.60 close — WOLFF ANDREW A, Schnieders Elisabeth, Morgan Bradley Paul and 5 more2017-05-18: 7 award or grants at $14.25 close — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 4 more2017-06-30: 2 award or grants at $12.10 close — Jaw Ching2017-08-08: 3 option exercises at $12.50 close — McDowell Caryn Gordon2017-08-29: 2 option exercises at $14.20 close — GAGE L PATRICK, COSTA SANTO J2017-08-31: 16 option exercises at $14.85 close — COSTA SANTO J, Morgan Bradley Paul2017-09-01: 1 option exercise at $14.75 close — GAGE L PATRICK2017-09-06: 3 option exercises at $14.10 close — McDowell Caryn Gordon2017-10-02: 1 option exercise at $14.90 close — GAGE L PATRICK2017-10-06: 3 option exercises at $15.50 close — McDowell Caryn Gordon2017-11-01: 4 option exercises at $12.90 close — Malik Fady Ibraham2017-11-02: 3 option exercises at $12.88 close — McDowell Caryn Gordon2018-01-02: 6 award or grants at $3.50 filed · Value $214.99K — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 3 more2018-01-16: 6 option exercises at $8.60 close — McDowell Caryn Gordon2018-02-08: 1 award or grant at $8.35 close — Califf Robert2018-02-27: 12 award or grants at $7.80 close — RODDY PETER S, McDowell Caryn Gordon, Malik Fady Ibraham and 3 more2018-05-16: 8 award or grants at $9.45 filed · Value $1.51M — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 5 more2019-01-02: 5 award or grants at $6.82 filed · Value $162.48K — Califf Robert, HENDERSON JOHN T, Kaye Edward M. MD and 2 more2019-01-31: 2 award or grants at $7.03 filed · Value $703.00K — SCHLOSSBERG MARK A2019-02-26: 8 award or grants at $7.14 filed · Value $3.00M — Malik Fady Ibraham, Jaw Ching, Cragg David and 1 more2019-05-15: 9 award or grants at $10.68 filed · Value $1.92M — HENDERSON JOHN T, WIERENGA WENDALL, PARSHALL B LYNNE and 5 more2020-01-02: 8 award or grants at $10.55 filed · Value $348.00K — Califf Robert, HENDERSON JOHN T, Kaye Edward M. MD and 1 more2020-02-12: 5 award or grants at $15.43 filed · Value $424.22K — SMITH SANDFORD D, PARSHALL B LYNNE, Kaye Edward M. MD and 2 more2020-03-06: 12 award or grants at $14.40 filed · Value $7.63M — Wong Robert, SCHLOSSBERG MARK A, Malik Fady Ibraham and 3 more2020-04-28: 2 option exercises at $16.00 filed · Value $159.98K — WIERENGA WENDALL2020-05-05: 2 option exercises at $17.00 filed · Value $141.64K — COSTA SANTO J2020-05-11: 3 option exercises at $19.65 filed · Value $594.68K — COSTA SANTO J2020-05-13: 8 award or grants at $21.61 filed · Value $3.46M — WIERENGA WENDALL, SMITH SANDFORD D, PARSHALL B LYNNE and 5 more2020-05-18: 2 option exercises at $22.19 filed · Value $166.89K — GAGE L PATRICK, Blum Robert I2020-05-19: 1 option exercise at $20.93 filed · Value $69.76K — HENDERSON JOHN T2020-05-29: 1 option exercise at $20.10 filed · Value $100.50K — Blum Robert I2020-06-11: 1 option exercise at $20.95 close — Blum Robert I2020-06-12: 2 option exercises at $21.38 close — SMITH SANDFORD D2020-06-15: 1 option exercise at $21.73 close — SMITH SANDFORD D2020-06-17: 2 option exercises at $23.01 close — SMITH SANDFORD D2020-06-22: 5 option exercises at $24.64 close — COSTA SANTO J, PARSHALL B LYNNE, SMITH SANDFORD D2020-06-24: 2 option exercises at $23.56 close — Blum Robert I2020-07-06: 1 option exercise at $24.35 close — Blum Robert I2020-07-07: 2 option exercises at $26.04 close — SMITH SANDFORD D2020-07-08: 1 option exercise at $26.92 close — SMITH SANDFORD D2020-07-10: 1 option exercise at $25.50 close — SMITH SANDFORD D2020-07-15: 1 option exercise at $28.96 close — SMITH SANDFORD D2020-07-16: 1 option exercise at $25.72 close — Blum Robert I2020-07-28: 1 option exercise at $23.18 close — Blum Robert I2020-07-29: 1 option exercise at $22.96 close — SCHLOSSBERG MARK A2020-08-05: 1 option exercise at $22.13 close — Blum Robert I2020-08-18: 1 option exercise at $24.12 close — Blum Robert I2020-08-21: 3 option exercises at $24.24 close — Jaw Ching, SCHLOSSBERG MARK A2020-09-04: 1 option exercise at $22.62 close — Blum Robert I2020-09-11: 1 option exercise at $22.49 close — Blum Robert I2020-09-21: 1 option exercise at $21.27 close — Blum Robert I2020-10-02: 1 option exercise at $23.99 close — Blum Robert I2020-10-05: 12 option exercises at $3.48 filed · Value $35.01K — PARSHALL B LYNNE, SMITH SANDFORD D, HENDERSON JOHN T and 3 more2020-10-13: 1 option exercise at $16.89 close — Blum Robert I2020-10-29: 1 option exercise at $15.49 close — Blum Robert I2020-11-10: 1 option exercise at $16.90 close — Blum Robert I2020-11-20: 1 award or grant at $15.99 filed · Value $559.65K — Wysenski Nancy2020-11-20: 3 other transactions at $15.99 close — Biotechnology Value Trading Fund OS LP | BVF II GP LLC | BIOTECHNOLOGY VALUE FUND II LP | BVF PARTNERS L P/IL | BVF INC/IL | BVF Partners OS Ltd. | LAMPERT MARK N | BVF I GP LLC | BVF GP HOLDINGS LLC | BIOTECHNOLOGY VALUE FUND L P2020-11-23: 1 option exercise at $16.07 close — Blum Robert I2020-12-04: 1 option exercise at $17.12 close — Blum Robert I2020-12-15: 5 option exercises at $21.00 close — Cragg David, GAGE L PATRICK2020-12-16: 1 option exercise at $21.00 close — Blum Robert I2020-12-31: 1 option exercise at $20.78 close — HENDERSON JOHN T2021-01-04: 1 option exercise at $19.56 close — Blum Robert I2021-01-14: 2 option exercises at $19.80 close — Malik Fady Ibraham2021-01-20: 1 option exercise at $19.98 close — Blum Robert I2021-01-29: 1 option exercise at $19.67 close — Blum Robert I2021-02-10: 1 option exercise at $23.16 close — Blum Robert I2021-02-17: 1 award or grant at $21.86 filed · Value $765.10K — Bhanji Muna2021-02-18: 4 option exercises at $21.01 close — Blum Robert I2021-02-26: 1 option exercise at $18.73 close — Blum Robert I2021-03-02: 12 award or grants at $19.42 filed · Value $7.28M — Wong Robert, SCHLOSSBERG MARK A, Malik Fady Ibraham and 3 more2021-03-08: 1 option exercise at $19.19 close — Blum Robert I2021-03-12: 2 option exercises at $22.82 close — GAGE L PATRICK2021-03-19: 1 option exercise at $24.86 close — GAGE L PATRICK2021-03-22: 2 option exercises at $24.86 close — Blum Robert I2021-03-31: 1 award or grant at $23.26 filed · Value $3.49M — Callos Andrew2021-04-01: 3 option exercises at $24.44 close — HENDERSON JOHN T2021-04-09: 6 option exercises at $24.16 close — SMITH SANDFORD D2021-04-12: 1 option exercise at $23.85 close — Blum Robert I2021-04-15: 2 option exercises at $24.87 close — SMITH SANDFORD D2021-04-23: 1 option exercise at $26.49 close — SMITH SANDFORD D2021-04-26: 1 option exercise at $26.99 close — SMITH SANDFORD D2021-04-27: 2 option exercises at $26.76 close — SMITH SANDFORD D2021-04-30: 1 option exercise at $25.44 close — Blum Robert I2021-05-07: 1 option exercise at $24.23 close — Blum Robert I2021-05-12: 10 award or grants at $24.32 close — Wysenski Nancy, WIERENGA WENDALL, PARSHALL B LYNNE and 7 more2021-05-20: 1 option exercise at $23.84 close — Blum Robert I2021-06-01: 2 option exercises at $21.70 close — Cragg David2021-06-03: 1 option exercise at $21.04 close — Blum Robert I2021-06-18: 1 option exercise at $21.31 close — Blum Robert I2021-07-06: 1 option exercise at $19.53 close — Blum Robert I2021-07-19: 3 option exercises at $27.00 close — SMITH SANDFORD D2021-07-22: 1 option exercise at $30.10 close — Blum Robert I2021-08-05: 1 option exercise at $30.24 close — Blum Robert I2021-08-18: 1 option exercise at $30.25 close — Blum Robert I2021-09-02: 1 option exercise at $33.52 close — Blum Robert I2021-09-15: 2 option exercises at $33.70 close — Blum Robert I2021-09-30: 1 option exercise at $35.74 close — Blum Robert I2021-10-14: 1 option exercise at $38.13 close — Blum Robert I2021-10-19: 3 option exercises at $35.32 close — SCHLOSSBERG MARK A, PARSHALL B LYNNE2021-10-29: 1 option exercise at $34.91 close — Blum Robert I2021-11-01: 2 option exercises at $34.35 close — Cragg David2021-11-05: 5 option exercises at $41.10 close — HENDERSON JOHN T, PARSHALL B LYNNE2021-11-08: 2 option exercises at $41.00 close — GAGE L PATRICK2021-11-09: 2 option exercises at $41.73 close — Cragg David2021-11-12: 1 option exercise at $39.19 close — Blum Robert I2021-11-19: 3 option exercises at $40.86 close — SMITH SANDFORD D2021-12-09: 2 option exercises at $35.03 close — Malik Fady Ibraham2021-12-23: 1 option exercise at $44.66 close — Kaye Edward M. MD2021-12-27: 4 option exercises at $45.85 close — WIERENGA WENDALL, SMITH SANDFORD D2022-02-07: 1 option exercise at $34.95 close — Blum Robert I2022-02-16: 1 option exercise at $36.72 close — Blum Robert I2022-03-01: 1 option exercise at $35.95 close — HENDERSON JOHN T2022-03-02: 14 award or grants at $37.63 filed · Value $17.08M — Wong Robert, SCHLOSSBERG MARK A, Malik Fady Ibraham and 4 more2022-03-02: 2 option exercises at $37.63 close — Blum Robert I, COSTA SANTO J2022-03-09: 1 option exercise at $38.13 close — Jaw Ching2022-03-10: 1 option exercise at $37.87 close — Malik Fady Ibraham2022-03-15: 3 option exercises at $33.94 close — SCHLOSSBERG MARK A2022-03-21: 1 option exercise at $35.57 close — Blum Robert I2022-04-04: 2 option exercises at $40.04 close — Jaw Ching, Blum Robert I2022-04-05: 1 option exercise at $40.35 close — Jaw Ching2022-04-07: 1 option exercise at $43.19 close — Malik Fady Ibraham2022-04-08: 1 award or grant at $41.69 filed · Value $1.46M — Harrington Robert Arthur2022-04-20: 1 option exercise at $37.81 close — Blum Robert I2022-05-04: 1 option exercise at $41.03 close — Blum Robert I2022-05-10: 9 award or grants at $37.89 close — Wysenski Nancy, WIERENGA WENDALL, SMITH SANDFORD D and 6 more2022-05-12: 1 option exercise at $38.35 close — Malik Fady Ibraham2022-05-16: 1 option exercise at $43.40 close — Blum Robert I2022-06-06: 1 option exercise at $39.41 close — Blum Robert I2022-06-09: 1 option exercise at $38.84 close — Malik Fady Ibraham2022-06-15: 1 option exercise at $41.11 close — Blum Robert I2022-07-06: 1 option exercise at $44.14 close — Blum Robert I2022-07-14: 1 option exercise at $43.17 close — Malik Fady Ibraham2022-07-18: 1 option exercise at $38.54 close — Blum Robert I2022-08-01: 1 option exercise at $41.11 close — Blum Robert I2022-08-05: 1 option exercise at $51.82 close — Kaye Edward M. MD2022-08-17: 1 option exercise at $50.57 close — Blum Robert I2022-09-01: 6 option exercises at $53.74 close — PARSHALL B LYNNE, , WIERENGA WENDALL2022-09-02: 3 option exercises at $54.06 close — SMITH SANDFORD D2022-09-07: 1 option exercise at $50.99 close — Blum Robert I2022-09-08: 1 option exercise at $54.05 close — Malik Fady Ibraham2022-09-12: 3 option exercises at $54.46 close — HENDERSON JOHN T2022-09-19: 1 option exercise at $52.31 close — Blum Robert I2022-10-03: 1 option exercise at $51.11 close — Blum Robert I2022-10-13: 1 option exercise at $48.64 close — Malik Fady Ibraham2022-10-19: 1 option exercise at $47.10 close — Blum Robert I2022-11-02: 2 option exercises at $41.87 close — Blum Robert I2022-11-21: 1 option exercise at $39.93 close — Blum Robert I2022-12-05: 1 option exercise at $38.12 close — Blum Robert I2022-12-21: 1 option exercise at $45.12 close — Blum Robert I2023-01-04: 1 option exercise at $42.70 close — Blum Robert I2023-01-17: 1 option exercise at $42.72 close — Blum Robert I2023-02-03: 1 option exercise at $45.01 close — Jaw Ching2023-02-06: 1 option exercise at $44.84 close — WIERENGA WENDALL2023-02-09: 1 option exercise at $44.30 close — Malik Fady Ibraham2023-03-06: 10 award or grants at $39.13 close — Wong Robert, Malik Fady Ibraham, Jaw Ching and 2 more2023-03-06: 1 option exercise at $39.13 close — Blum Robert I2023-03-15: 1 option exercise at $37.27 close — Blum Robert I2023-03-28: 1 option exercise at $34.98 close — Blum Robert I2023-04-14: 1 option exercise at $34.78 close — Blum Robert I2023-04-28: 1 option exercise at $37.40 close — Blum Robert I2023-05-03: 1 option exercise at $39.34 close — Malik Fady Ibraham2023-05-10: 9 award or grants at $39.23 close — SMITH SANDFORD D, WIERENGA WENDALL, Wysenski Nancy and 6 more2023-05-15: 1 option exercise at $38.95 close — HENDERSON JOHN T2023-05-16: 1 option exercise at $37.23 close — Blum Robert I2023-05-31: 1 option exercise at $37.69 close — Blum Robert I2023-06-12: 1 option exercise at $35.96 close — Blum Robert I2023-07-03: 1 option exercise at $33.36 close — Blum Robert I2023-07-13: 1 option exercise at $35.50 close — Blum Robert I2023-08-01: 2 option exercises at $32.50 close — Blum Robert I2023-08-11: 2 option exercises at $32.75 close — Blum Robert I2023-08-21: 1 option exercise at $32.94 close — WIERENGA WENDALL2023-08-25: 2 option exercises at $34.86 close — Blum Robert I2023-09-13: 1 option exercise at $34.83 close — Blum Robert I2023-10-06: 1 option exercise at $30.60 close — Blum Robert I2023-10-16: 1 option exercise at $34.65 close — Blum Robert I2023-10-30: 1 option exercise at $32.09 close — Blum Robert I2023-11-15: 1 option exercise at $32.83 close — Blum Robert I2023-11-30: 1 option exercise at $33.48 close — Blum Robert I2023-12-18: 2 option exercises at $36.09 close — Blum Robert I, HENDERSON JOHN T2023-12-27: 2 option exercises at $83.44 close — WIERENGA WENDALL2024-01-02: 1 option exercise at $84.12 close — Blum Robert I2024-01-04: 1 option exercise at $88.24 close — Malik Fady Ibraham2024-01-12: 1 option exercise at $85.60 close — HENDERSON JOHN T2024-01-19: 1 option exercise at $80.96 close — Blum Robert I2024-01-31: 1 option exercise at $78.13 close — Blum Robert I2024-02-06: 1 option exercise at $80.16 close — Malik Fady Ibraham2024-02-13: 1 option exercise at $77.03 close — Blum Robert I2024-02-14: 1 option exercise at $76.50 close — HENDERSON JOHN T2024-03-05: 1 option exercise at $66.43 close — Malik Fady Ibraham2024-03-14: 8 award or grants at $63.75 close — Wong Robert, Callos Andrew, Malik Fady Ibraham and 1 more2024-04-09: 1 option exercise at $75.05 close — Malik Fady Ibraham2024-05-07: 1 option exercise at $65.28 close — Malik Fady Ibraham2024-05-15: 8 award or grants at $60.50 close — Bhanji Muna, COSTA SANTO J, Harrington Robert Arthur and 5 more2024-05-31: 1 award or grant at $48.51 close — Lee Sung2024-06-03: 1 option exercise at $49.87 close — PARSHALL B LYNNE2024-06-11: 1 option exercise at $53.29 close — Malik Fady Ibraham2024-06-17: 1 option exercise at $52.78 close — PARSHALL B LYNNE2024-06-25: 1 option exercise at $52.87 close — Malik Fady Ibraham2024-07-01: 1 option exercise at $54.70 close — PARSHALL B LYNNE2024-07-09: 1 option exercise at $54.86 close — Malik Fady Ibraham2024-07-10: 1 option exercise at $54.93 close — Blum Robert I2024-07-15: 1 option exercise at $57.39 close — PARSHALL B LYNNE2024-07-23: 1 option exercise at $57.38 close — Malik Fady Ibraham2024-07-29: 1 option exercise at $59.09 close — PARSHALL B LYNNE2024-07-30: 1 option exercise at $60.16 close — Blum Robert I2024-08-07: 1 option exercise at $51.22 close — Malik Fady Ibraham2024-08-12: 2 option exercises at $56.18 close — Blum Robert I, PARSHALL B LYNNE2024-08-20: 1 option exercise at $56.85 close — Malik Fady Ibraham2024-08-26: 1 option exercise at $57.07 close — PARSHALL B LYNNE2024-08-30: 1 award or grant at $57.08 close — Pletcher Brett A2024-09-03: 2 option exercises at $54.56 close — Malik Fady Ibraham, Blum Robert I2024-09-09: 1 option exercise at $55.83 close — PARSHALL B LYNNE2024-09-16: 1 option exercise at $56.75 close — Blum Robert I2024-09-17: 1 option exercise at $56.16 close — Malik Fady Ibraham2024-09-30: 1 option exercise at $52.80 close — Blum Robert I2024-10-01: 1 option exercise at $52.60 close — Malik Fady Ibraham2024-10-09: 1 option exercise at $54.40 close — Blum Robert I2024-10-15: 1 option exercise at $55.38 close — Malik Fady Ibraham2024-10-28: 1 option exercise at $52.26 close — WIERENGA WENDALL2024-10-30: 1 option exercise at $51.31 close — Malik Fady Ibraham2024-11-01: 1 option exercise at $51.82 close — Blum Robert I2024-11-12: 1 option exercise at $56.19 close — Malik Fady Ibraham2024-11-18: 1 option exercise at $51.94 close — Blum Robert I2024-11-25: 1 option exercise at $50.25 close — WIERENGA WENDALL2024-11-26: 1 option exercise at $52.02 close — Malik Fady Ibraham2024-12-02: 1 option exercise at $50.63 close — Blum Robert I2024-12-10: 1 option exercise at $50.55 close — Malik Fady Ibraham2024-12-11: 2 option exercises at $50.70 close — HENDERSON JOHN T2024-12-16: 1 option exercise at $49.02 close — WIERENGA WENDALL2025-01-07: 1 option exercise at $48.51 close — Malik Fady Ibraham2025-01-21: 1 option exercise at $45.82 close — Malik Fady Ibraham2025-02-04: 1 option exercise at $49.20 close — Malik Fady Ibraham2025-02-10: 1 award or grant at $42.21 close — Landry Robert E2025-02-18: 1 option exercise at $45.39 close — Malik Fady Ibraham2025-03-04: 1 option exercise at $43.69 close — Malik Fady Ibraham2025-03-14: 8 award or grants at $44.36 close — Lee Sung, Callos Andrew, Malik Fady Ibraham and 1 more2025-03-14: 1 option exercise at $44.36 close — Callos Andrew2025-03-17: 1 option exercise at $44.91 close — Callos Andrew2025-03-18: 1 option exercise at $43.28 close — Malik Fady Ibraham2025-04-08: 1 option exercise at $34.57 close — Malik Fady Ibraham2025-04-15: 1 option exercise at $38.56 close — HENDERSON JOHN T2025-04-21: 1 option exercise at $37.93 close — WIERENGA WENDALL2025-04-22: 1 option exercise at $37.81 close — Malik Fady Ibraham2025-05-06: 1 option exercise at $33.97 close — Malik Fady Ibraham2025-05-14: 8 award or grants at $30.00 close — Harrington Robert Arthur, PARSHALL B LYNNE, Bhanji Muna and 5 more2025-05-20: 1 option exercise at $32.66 close — Malik Fady Ibraham2025-06-03: 1 option exercise at $32.00 close — Malik Fady Ibraham2025-06-17: 1 option exercise at $32.54 close — Malik Fady Ibraham2025-07-08: 1 option exercise at $34.25 close — Malik Fady Ibraham2025-07-22: 1 option exercise at $37.70 close — Malik Fady Ibraham2025-08-05: 1 option exercise at $36.16 close — Malik Fady Ibraham2025-08-19: 1 award or grant at $37.84 close — Daly James M2025-08-19: 1 option exercise at $37.84 close — Malik Fady Ibraham2025-09-09: 1 option exercise at $51.50 close — Malik Fady Ibraham2025-09-23: 1 option exercise at $48.55 close — Malik Fady Ibraham2025-10-07: 1 option exercise at $60.17 close — Malik Fady Ibraham2025-10-21: 1 option exercise at $57.78 close — Malik Fady Ibraham2025-10-27: 1 option exercise at $60.18 close — WIERENGA WENDELL2025-11-04: 1 option exercise at $59.62 close — Malik Fady Ibraham2025-11-11: 1 option exercise at $66.50 close — Kaye Edward M. MD2025-11-18: 1 option exercise at $66.16 close — Malik Fady Ibraham2025-12-01: 2 option exercises at $66.05 close — Kaye Edward M. MD2025-12-02: 2 option exercises at $63.51 close — HENDERSON JOHN T, Malik Fady Ibraham2025-12-05: 4 option exercises at $65.67 close — Callos Andrew2025-12-08: 1 option exercise at $64.13 close — Callos Andrew2025-12-16: 1 option exercise at $62.02 close — Malik Fady Ibraham2025-12-22: 3 option exercises at $65.60 close — Blum Robert I, WIERENGA WENDELL2026-01-02: 1 option exercise at $61.73 close — Callos Andrew2026-01-05: 1 option exercise at $61.26 close — Callos Andrew2026-02-02: 1 option exercise at $65.16 close — Callos Andrew2026-02-05: 1 option exercise at $60.24 close — Callos Andrew2026-03-02: 1 option exercise at $61.43 close — Callos Andrew2026-03-05: 2 option exercises at $62.19 close — Callos Andrew2026-03-15: 10 award or grants at $60.06 close — Blum Robert I, Callos Andrew, Hessekiel Jeffrey and 2 more2026-04-07: 2 option exercises at $65.48 close — Malik Fady Ibraham2026-04-21: 1 option exercise at $65.80 close — Malik Fady Ibraham2026-04-30: 1 option exercise at $63.97 close — Callos Andrew2026-05-01: 1 option exercise at $63.35 close — Callos Andrew2026-05-05: 4 option exercises at $77.09 close — Malik Fady Ibraham, WIERENGA WENDELL, HENDERSON JOHN T and 1 more2026-05-19: 1 option exercise at $76.45 close — Malik Fady Ibraham2026-05-27: 9 award or grants at $77.15 close — Bhanji Muna, Daly James M, Harrington Robert Arthur and 6 more2026-06-01: 1 option exercise at $73.68 close — Callos Andrew2026-06-09: 1 option exercise at $68.45 close — Malik Fady Ibraham2026-06-23: 1 option exercise at $80.01 close — Malik Fady Ibraham2026-06-24: 7 option exercises at $81.20 close — Lee Sung2026-06-29: 5 option exercises at $87.26 close — Lee Sung2026-07-01: 2 option exercises at $85.26 close — Callos Andrew, Lee Sung2026-07-07: 1 option exercise at $85.56 close — Malik Fady Ibraham2026-07-13: 1 option exercise at $82.24 close — Blum Robert I2026-07-21: 1 option exercise at $81.11 close — Malik Fady Ibraham2026-07-27: 1 option exercise at $80.62 close — Blum Robert I2026-07-30: 1 option exercise at $80.42 close — Callos Andrew2026-08-10: 1 option exercise at $77.49 close — Blum Robert I2026-08-18: 1 option exercise at $76.10 close — Malik Fady Ibraham2026-08-31: 2 option exercises at $70.91 close — Callos Andrew, Blum Robert I2026-09-08: 1 option exercise at $75.35 close — Malik Fady Ibraham2026-09-14: 1 option exercise at $72.45 close — Blum Robert I2026-09-22: 1 option exercise at $67.59 close — Malik Fady Ibraham

Logarithmic scale. Both lines share the same starting value for the selected range.

Markers: each transaction type positioned at that session's split-adjusted close. Tooltips retain the reported transaction price when available.

Transaction dateReporting ownerFormSecurityTransactionSharesPricePrice that dayFiling
2026-09-22Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
23,386 owned after
$7.80
exercise price
$67.592026-09-22
2026-09-14Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−7,500
156,745 owned after
$10.60
exercise price
$72.452026-09-15
2026-09-08Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
26,886 owned after
$7.80
exercise price
$75.352026-09-08
2026-08-31Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−10,000
0 owned after
$23.26
exercise price
$70.912026-08-31
2026-08-31Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−7,500
164,245 owned after
$10.60
exercise price
$70.912026-08-31
2026-08-18Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
30,386 owned after
$7.80
exercise price
$76.102026-08-18
2026-08-10Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−7,500
171,745 owned after
$10.60
exercise price
$77.492026-08-10
2026-07-30Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−14,000
10,000 owned after
$23.26
exercise price
$80.422026-07-30
2026-07-27Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−7,500
179,245 owned after
$10.60
exercise price
$80.622026-07-27
2026-07-21Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
33,886 owned after
$7.80
exercise price
$81.112026-07-23
2026-07-13Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−7,490
186,745 owned after
$10.60
exercise price
$82.242026-07-14
2026-07-07Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
37,386 owned after
$7.80
exercise price
$85.562026-07-07
2026-07-01Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
24,000 owned after
$23.26
exercise price
$85.262026-07-02
2026-07-01Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−1,112
26,709 owned after
$48.51
exercise price
$85.262026-07-02
2026-06-29Lee Sung
Officer (EVP, Chief Financial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−188
8,828 owned after
$44.36
exercise price
$87.262026-06-29
2026-06-29Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−822
40,504 owned after
$44.36
exercise price
$87.262026-06-29
2026-06-29Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−1,113
52,304 owned after
$48.51
exercise price
$87.262026-06-29
2026-06-29Lee Sung
Officer (EVP, Chief Financial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−188
8,640 owned after
$44.36
exercise price
$87.262026-06-29
2026-06-29Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−823
39,681 owned after
$44.36
exercise price
$87.262026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−23,370
30,047 owned after
$48.51
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−9,307
32,019 owned after
$44.36
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−2,817
6,199 owned after
$44.36
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−1,113
28,934 owned after
$48.51
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−188
6,011 owned after
$44.36
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−822
31,197 owned after
$44.36
exercise price
$81.202026-06-29
2026-06-24Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−1,113
27,821 owned after
$48.51
exercise price
$81.202026-06-29
2026-06-23Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
40,886 owned after
$7.80
exercise price
$80.012026-06-23
2026-06-09Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
44,386 owned after
$7.80
exercise price
$68.452026-06-09
2026-06-01Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
39,000 owned after
$23.26
exercise price
$73.682026-06-01
2026-05-27Bhanji Muna
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27Daly James M
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27Harrington Robert Arthur
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27HENDERSON JOHN T
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27Kaye Edward M. MD
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27PARSHALL B LYNNE
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27Landry Robert E
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27WIERENGA WENDELL
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-27Wysenski Nancy
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+4,301
4,301 owned after
$77.15
exercise price
$77.152026-05-27
2026-05-19Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
47,886 owned after
$7.80
exercise price
$76.452026-05-20
2026-05-05Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
51,386 owned after
$7.80
exercise price
$77.092026-05-05
2026-05-05WIERENGA WENDELL
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−4,032
0 owned after
$12.40
exercise price
$77.092026-05-05
2026-05-05HENDERSON JOHN T
Director
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−20,000
0 owned after
$7.61
exercise price
$77.092026-05-05
2026-05-05Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−11,333
13,070 owned after
$39.13
exercise price
$77.092026-05-05
2026-05-01Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,857
0 owned after
$37.63
exercise price
$63.352026-05-04
2026-04-30Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
54,000 owned after
$23.26
exercise price
$63.972026-04-30
2026-04-21Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
54,886 owned after
$7.80
exercise price
$65.802026-04-21
2026-04-07Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−3,500
58,386 owned after
$7.80
exercise price
$65.482026-04-08
2026-04-07Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−1,000
0 owned after
$10.60
exercise price
$65.482026-04-08
2026-03-15Blum Robert I
Director, Officer (President & CEO)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+1,665
1,665 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Blum Robert I
Director, Officer (President & CEO)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+111,864
111,864 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+1,665
1,665 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+29,480
29,480 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Hessekiel Jeffrey
Officer (Chief Legal & Admin Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+8,325
8,325 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Hessekiel Jeffrey
Officer (Chief Legal & Admin Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+22,820
22,820 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Lee Sung
Officer (EVP, Chief Financial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+1,665
1,665 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Lee Sung
Officer (EVP, Chief Financial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+29,480
29,480 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Malik Fady Ibraham
Officer (EVP Research & Development)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+1,665
1,665 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-15Malik Fady Ibraham
Officer (EVP Research & Development)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
A Grant, award or other acquisition pursuant to Rule 16b-3(d)+39,527
39,527 owned after
$60.06
exercise price
$60.062026-03-17
2026-03-05Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−11,000
24,403 owned after
$39.13
exercise price
$62.192026-03-05
2026-03-05Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
69,000 owned after
$23.26
exercise price
$62.192026-03-05
2026-03-02Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−886
0 owned after
$37.63
exercise price
$61.432026-03-02
2026-02-05Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
84,000 owned after
$23.26
exercise price
$60.242026-02-05
2026-02-02Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−886
886 owned after
$37.63
exercise price
$65.162026-02-02
2026-01-05Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Non-Qualified Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−15,000
99,000 owned after
$23.26
exercise price
$61.262026-01-05
2026-01-02Callos Andrew
Officer (EVP, Chief Commercial Officer)
4Incentive Stock Option (Right to Buy)
Derivative · Direct
M Exercise or conversion of derivative security exempted pursuant to Rule 16b-3−885
1,772 owned after
$37.63
exercise price
$61.732026-01-02

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