PBE additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
|---|---|---|---|
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2026-04-30 | Added / first present |
| CareDx, Inc. | CareDx, Inc. | 2026-04-30 | Added / first present |
| Theravance Biopharma Inc. | Theravance Biopharma Inc. | 2026-04-30 | Added / first present |
| Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | 2026-01-31 | Added / first present |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2026-01-31 | Added / first present |
| TG Therapeutics, Inc. | TG Therapeutics, Inc. | 2026-01-31 | Added / first present |
| Repligen Corp. | Repligen Corp. | 2026-01-31 | Added / first present |
| Protagonist Therapeutics, Inc. | Protagonist Therapeutics, Inc. | 2026-01-31 | Added / first present |
| Qiagen N.V. | Qiagen N.V. | 2026-01-31 | Added / first present |
| Biogen Inc. | Biogen Inc. | 2025-10-31 | Added / first present |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2025-10-31 | Added / first present |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2025-10-31 | Added / first present |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2025-10-31 | Added / first present |
| Madrigal Pharmaceuticals, Inc. | Madrigal Pharmaceuticals, Inc. | 2025-10-31 | Added / first present |
| CorMedix Inc. | CorMedix Inc. | 2025-10-31 | Added / first present |
| Vericel Corp. | Vericel Corp. | 2025-10-31 | Added / first present |
| Akebia Therapeutics, Inc. | Akebia Therapeutics, Inc. | 2025-10-31 | Added / first present |
| Bio-Techne Corp. | Bio-Techne Corp. | 2025-10-31 | Added / first present |
| Vertex Pharmaceuticals Inc. | Vertex Pharmaceuticals Inc. | 2025-07-31 | Added / first present |
| Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | 2025-07-31 | Added / first present |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2025-07-31 | Added / first present |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2025-07-31 | Added / first present |
| Repligen Corp. | Repligen Corp. | 2025-07-31 | Added / first present |
| Anavex Life Sciences Corp. | Anavex Life Sciences Corp. | 2025-07-31 | Added / first present |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2025-04-30 | Added / first present |
| Dynavax Technologies Corp. | Dynavax Technologies Corp. | 2025-04-30 | Added / first present |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2025-01-31 | Added / first present |
| Exact Sciences Corp. | Exact Sciences Corp. | 2025-01-31 | Added / first present |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2025-01-31 | Added / first present |
| Axsome Therapeutics, Inc. | Axsome Therapeutics, Inc. | 2025-01-31 | Added / first present |
| Royalty Pharma PLC | Royalty Pharma PLC | 2025-01-31 | Added / first present |
| Qiagen N.V. | Qiagen N.V. | 2025-01-31 | Added / first present |
| Biogen Inc. | Biogen Inc. | 2024-10-31 | Added / first present |
| Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | 2024-10-31 | Added / first present |
| Acadia Pharmaceuticals Inc. | Acadia Pharmaceuticals Inc. | 2024-10-31 | Added / first present |
| Natera, Inc. | Natera, Inc. | 2024-10-31 | Added / first present |
| CareDx, Inc. | CareDx, Inc. | 2024-10-31 | Added / first present |
| BioCryst Pharmaceuticals, Inc. | BioCryst Pharmaceuticals, Inc. | 2024-10-31 | Added / first present |
| Novavax, Inc. | Novavax, Inc. | 2024-10-31 | Added / first present |
| Protagonist Therapeutics, Inc. | Protagonist Therapeutics, Inc. | 2024-10-31 | Added / first present |
| Illumina, Inc. | Illumina, Inc. | 2024-07-31 | Added / first present |
| Incyte Corp. | Incyte Corp. | 2024-07-31 | Added / first present |
| Sage Therapeutics, Inc. | Sage Therapeutics, Inc. | 2024-07-31 | Added / first present |
| Xencor, Inc. | Xencor, Inc. | 2024-07-31 | Added / first present |
| Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. | 2024-07-31 | Added / first present |
| OPKO Health, Inc. | OPKO Health, Inc. | 2024-07-31 | Added / first present |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2024-04-30 | Added / first present |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2024-04-30 | Added / first present |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2024-04-30 | Added / first present |
| Bio-Techne Corp. | Bio-Techne Corp. | 2024-04-30 | Added / first present |
| Xenon Pharmaceuticals Inc. | Xenon Pharmaceuticals Inc. | 2024-04-30 | Added / first present |
| EyePoint Pharmaceuticals, Inc. | EyePoint Pharmaceuticals, Inc. | 2024-04-30 | Added / first present |
| Illumina, Inc. | Illumina, Inc. | 2024-01-31 | Added / first present |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2024-01-31 | Added / first present |
| Collegium Pharmaceutical, Inc. | Collegium Pharmaceutical, Inc. | 2024-01-31 | Added / first present |
| ImmunoGen, Inc. | ImmunoGen, Inc. | 2024-01-31 | Added / first present |
| TG Therapeutics, Inc. | TG Therapeutics, Inc. | 2024-01-31 | Added / first present |
| Celldex Therapeutics, Inc. | Celldex Therapeutics, Inc. | 2024-01-31 | Added / first present |
| Qiagen N.V. | Qiagen N.V. | 2024-01-31 | Added / first present |
| Amgen Inc. | Amgen Inc. | 2023-10-31 | Added / first present |
| Incyte Corp. | Incyte Corp. | 2023-10-31 | Added / first present |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2023-10-31 | Added / first present |
| OPKO Health, Inc. | OPKO Health, Inc. | 2023-10-31 | Added / first present |
| Intra-Cellular Therapies, Inc. | Intra-Cellular Therapies, Inc. | 2023-10-31 | Added / first present |
| Fulgent Genetics, Inc. | Fulgent Genetics, Inc. | 2023-10-31 | Added / first present |
| Illumina, Inc. | Illumina, Inc. | 2023-07-31 | Added / first present |
| Viking Therapeutics, Inc. | Viking Therapeutics, Inc. | 2023-07-31 | Added / first present |
| TG Therapeutics, Inc. | TG Therapeutics, Inc. | 2023-07-31 | Added / first present |
| CymaBay Therapeutics, Inc. | CymaBay Therapeutics, Inc. | 2023-07-31 | Added / first present |
| MannKind Corp. | MannKind Corp. | 2023-07-31 | Added / first present |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2023-07-31 | Added / first present |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2023-07-31 | Added / first present |
| Qiagen N.V. | Qiagen N.V. | 2023-07-31 | Added / first present |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2023-04-30 | Added / first present |
| FibroGen, Inc. | FibroGen, Inc. | 2023-04-30 | Added / first present |
| Catalent, Inc. | Catalent, Inc. | 2023-04-30 | Added / first present |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2023-01-31 | Added / first present |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2023-01-31 | Added / first present |
| Avid Bioservices, Inc. | Avid Bioservices, Inc. | 2023-01-31 | Added / first present |
| Cassava Sciences, Inc. | Cassava Sciences, Inc. | 2023-01-31 | Added / first present |
| BioMarin Pharmaceutical Inc. | BioMarin Pharmaceutical Inc. | 2022-10-31 | Added / first present |
| FibroGen, Inc. | FibroGen, Inc. | 2022-10-31 | Added / first present |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2022-10-31 | Added / first present |
| Veracyte, Inc. | Veracyte, Inc. | 2022-10-31 | Added / first present |
| Vericel Corp. | Vericel Corp. | 2022-10-31 | Added / first present |
| Catalyst Pharmaceuticals, Inc. | Catalyst Pharmaceuticals, Inc. | 2022-10-31 | Added / first present |
| Invesco Government & Agency Portfolio | Invesco Government & Agency Portfolio | 2022-10-31 | Added / first present |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2022-07-31 | Added / first present |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2022-07-31 | Added / first present |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2022-07-31 | Added / first present |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2022-07-31 | Added / first present |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2022-07-31 | Added / first present |
| Vertex Pharmaceuticals, Inc. | Vertex Pharmaceuticals, Inc. | 2022-04-30 | Added / first present |
| Incyte Corp. | Incyte Corp. | 2022-04-30 | Added / first present |
| Acadia Pharmaceuticals, Inc. | Acadia Pharmaceuticals, Inc. | 2022-04-30 | Added / first present |
| FibroGen, Inc. | FibroGen, Inc. | 2022-04-30 | Added / first present |
| Xencor, Inc. | Xencor, Inc. | 2022-04-30 | Added / first present |
| OPKO Health, Inc. | OPKO Health, Inc. | 2022-04-30 | Added / first present |
| ChemoCentryx, Inc. | ChemoCentryx, Inc. | 2022-04-30 | Added / first present |
| Enanta Pharmaceuticals, Inc. | Enanta Pharmaceuticals, Inc. | 2022-04-30 | Added / first present |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2022-01-31 | Added / first present |
| Intellia Therapeutics, Inc. | Intellia Therapeutics, Inc. | 2022-01-31 | Added / first present |
| Novavax, Inc. | Novavax, Inc. | 2022-01-31 | Added / first present |
| Cytokinetics, Inc. | Cytokinetics, Inc. | 2022-01-31 | Added / first present |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2022-01-31 | Added / first present |
| Xenon Pharmaceuticals, Inc. | Xenon Pharmaceuticals, Inc. | 2022-01-31 | Added / first present |
| Anavex Life Sciences Corp. | Anavex Life Sciences Corp. | 2022-01-31 | Added / first present |
| Incyte Corp. | Incyte Corp. | 2021-10-31 | Added / first present |
| Dicerna Pharmaceuticals, Inc. | Dicerna Pharmaceuticals, Inc. | 2021-10-31 | Added / first present |
| CareDx, Inc. | CareDx, Inc. | 2021-10-31 | Added / first present |
| Dynavax Technologies Corp. | Dynavax Technologies Corp. | 2021-10-31 | Added / first present |
| Celldex Therapeutics, Inc. | Celldex Therapeutics, Inc. | 2021-10-31 | Added / first present |
| Avid Bioservices, Inc. | Avid Bioservices, Inc. | 2021-10-31 | Added / first present |
| Prothena Corp. PLC | Prothena Corp. PLC | 2021-10-31 | Added / first present |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2021-07-31 | Added / first present |
| Biogen, Inc. | Biogen, Inc. | 2021-07-31 | Added / first present |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2021-07-31 | Added / first present |
| Neurocrine Biosciences, Inc. | Neurocrine Biosciences, Inc. | 2021-07-31 | Added / first present |
| Cardiovascular Systems, Inc. | Cardiovascular Systems, Inc. | 2021-07-31 | Added / first present |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2021-07-31 | Added / first present |
| Exelixis, Inc. | Exelixis, Inc. | 2021-07-31 | Added / first present |
| Repligen Corp. | Repligen Corp. | 2021-07-31 | Added / first present |
| Amgen, Inc. | Amgen, Inc. | 2021-04-30 | Added / first present |
| Illumina, Inc. | Illumina, Inc. | 2021-04-30 | Added / first present |
| BioMarin Pharmaceutical, Inc. | BioMarin Pharmaceutical, Inc. | 2021-04-30 | Added / first present |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2021-04-30 | Added / first present |
| Veracyte, Inc. | Veracyte, Inc. | 2021-04-30 | Added / first present |
| MannKind Corp. | MannKind Corp. | 2021-04-30 | Added / first present |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2021-04-30 | Added / first present |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2021-04-30 | Added / first present |
| Alexion Pharmaceuticals, Inc. | Alexion Pharmaceuticals, Inc. | 2021-01-31 | Added / first present |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2021-01-31 | Added / first present |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2021-01-31 | Added / first present |
| Xencor, Inc. | Xencor, Inc. | 2021-01-31 | Added / first present |
| Vericel Corp. | Vericel Corp. | 2021-01-31 | Added / first present |
| Five Prime Therapeutics, Inc. | Five Prime Therapeutics, Inc. | 2021-01-31 | Added / first present |
| Bio-Techne Corp. | Bio-Techne Corp. | 2021-01-31 | Added / first present |
| Catalent, Inc. | Catalent, Inc. | 2021-01-31 | Added / first present |
| Repligen Corp. | Repligen Corp. | 2021-01-31 | Added / first present |
| Fulgent Genetics, Inc. | Fulgent Genetics, Inc. | 2021-01-31 | Added / first present |
| Precigen, Inc. | Precigen, Inc. | 2021-01-31 | Added / first present |
| Seagen, Inc. | Seagen, Inc. | 2021-01-31 | Added / first present |
| Illumina, Inc. | Illumina, Inc. | 2020-10-31 | Added / first present |
| FibroGen, Inc. | FibroGen, Inc. | 2020-10-31 | Added / first present |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2020-10-31 | Added / first present |
| Insmed, Inc. | Insmed, Inc. | 2020-10-31 | Added / first present |
| Fate Therapeutics, Inc. | Fate Therapeutics, Inc. | 2020-10-31 | Added / first present |
| Sangamo Therapeutics, Inc. | Sangamo Therapeutics, Inc. | 2020-10-31 | Added / first present |
| Intellia Therapeutics, Inc. | Intellia Therapeutics, Inc. | 2020-10-31 | Added / first present |
| Fluidigm Corp. | Fluidigm Corp. | 2020-10-31 | Added / first present |
| Exelixis, Inc. | Exelixis, Inc. | 2020-10-31 | Added / first present |
| Invesco Government & Agency Portfolio | Invesco Government & Agency Portfolio | 2020-10-31 | Added / first present |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2020-10-31 | Added / first present |
| QIAGEN NV | QIAGEN NV | 2020-10-31 | Added / first present |
| Alkermes PLC | Alkermes PLC | 2020-10-31 | Added / first present |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2020-07-31 | Added / first present |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2020-07-31 | Added / first present |
| Nektar Therapeutics | Nektar Therapeutics | 2020-07-31 | Added / first present |
| United Therapeutics Corp. | United Therapeutics Corp. | 2020-07-31 | Added / first present |
| Acceleron Pharma, Inc. | Acceleron Pharma, Inc. | 2020-07-31 | Added / first present |
| MyoKardia, Inc. | MyoKardia, Inc. | 2020-07-31 | Added / first present |
| OPKO Health, Inc. | OPKO Health, Inc. | 2020-07-31 | Added / first present |
| CareDx, Inc. | CareDx, Inc. | 2020-07-31 | Added / first present |
| Vericel Corp. | Vericel Corp. | 2020-07-31 | Added / first present |
| ImmunoGen, Inc. | ImmunoGen, Inc. | 2020-07-31 | Added / first present |
| Vanda Pharmaceuticals, Inc. | Vanda Pharmaceuticals, Inc. | 2020-07-31 | Added / first present |
| Compugen Ltd. | Compugen Ltd. | 2020-07-31 | Added / first present |
| Vertex Pharmaceuticals, Inc. | Vertex Pharmaceuticals, Inc. | 2020-04-30 | Added / first present |
| Neurocrine Biosciences, Inc. | Neurocrine Biosciences, Inc. | 2020-04-30 | Added / first present |
| Invesco Private Government Fund | Invesco Private Government Fund | 2020-04-30 | Added / first present |
| Arena Pharmaceuticals, Inc. | Arena Pharmaceuticals, Inc. | 2020-04-30 | Added / first present |
| Halozyme Therapeutics, Inc. | Halozyme Therapeutics, Inc. | 2020-04-30 | Added / first present |
| FibroGen, Inc. | FibroGen, Inc. | 2020-04-30 | Added / first present |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2020-04-30 | Added / first present |
| Xencor, Inc. | Xencor, Inc. | 2020-04-30 | Added / first present |
| Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. | 2020-04-30 | Added / first present |
| Cardiovascular Systems, Inc. | Cardiovascular Systems, Inc. | 2020-04-30 | Added / first present |
| Coherus Biosciences, Inc. | Coherus Biosciences, Inc. | 2020-04-30 | Added / first present |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2020-04-30 | Added / first present |
| Esperion Therapeutics, Inc. | Esperion Therapeutics, Inc. | 2020-04-30 | Added / first present |
| Dicerna Pharmaceuticals, Inc. | Dicerna Pharmaceuticals, Inc. | 2020-04-30 | Added / first present |
| Akebia Therapeutics, Inc. | Akebia Therapeutics, Inc. | 2020-04-30 | Added / first present |
| Intra-Cellular Therapies, Inc. | Intra-Cellular Therapies, Inc. | 2020-04-30 | Added / first present |
| Collegium Pharmaceutical, Inc. | Collegium Pharmaceutical, Inc. | 2020-04-30 | Added / first present |
| ChemoCentryx, Inc. | ChemoCentryx, Inc. | 2020-04-30 | Added / first present |
| Bio-Techne Corp. | Bio-Techne Corp. | 2020-04-30 | Added / first present |
| Exelixis, Inc. | Exelixis, Inc. | 2020-04-30 | Added / first present |
| Invesco Premier U.S. Government Money Portfolio | Invesco Premier U.S. Government Money Portfolio | 2020-04-30 | Added / first present |
| Catalent, Inc. | Catalent, Inc. | 2020-04-30 | Added / first present |
| Repligen Corp. | Repligen Corp. | 2020-04-30 | Added / first present |
| Emergent BioSolutions, Inc. | Emergent BioSolutions, Inc. | 2020-04-30 | Added / first present |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2020-04-30 | Added / first present |
| CRISPR Therapeutics AG | CRISPR Therapeutics AG | 2020-04-30 | Added / first present |
| Alkermes PLC | Alkermes PLC | 2020-04-30 | Added / first present |
| Merck & Co., Inc. | Merck & Co., Inc. | 2020-01-31 | Added / first present |
| AbbVie, Inc. | AbbVie, Inc. | 2020-01-31 | Added / first present |
| Bristol-Myers Squibb Co. | Bristol-Myers Squibb Co. | 2020-01-31 | Added / first present |
| Johnson & Johnson | Johnson & Johnson | 2020-01-31 | Added / first present |
| Pfizer, Inc. | Pfizer, Inc. | 2020-01-31 | Added / first present |
| Abbott Laboratories | Abbott Laboratories | 2020-01-31 | Added / first present |
| Eli Lilly and Co. | Eli Lilly and Co. | 2020-01-31 | Added / first present |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Jazz Pharmaceuticals PLC | Jazz Pharmaceuticals PLC | 2020-01-31 | Added / first present |
| Bausch Health Cos. Inc. | Bausch Health Cos. Inc. | 2020-01-31 | Added / first present |
| Pacira BioSciences, Inc. | Pacira BioSciences, Inc. | 2020-01-31 | Added / first present |
| ANI Pharmaceuticals, Inc. | ANI Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Amphastar Pharmaceuticals, Inc. | Amphastar Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Innoviva, Inc. | Innoviva, Inc. | 2020-01-31 | Added / first present |
| Supernus Pharmaceuticals, Inc. | Supernus Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Eagle Pharmaceuticals, Inc. | Eagle Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Corcept Therapeutics, Inc. | Corcept Therapeutics, Inc. | 2020-01-31 | Added / first present |
| Mylan N.V. | Mylan N.V. | 2020-01-31 | Added / first present |
| Ligand Pharmaceuticals, Inc. | Ligand Pharmaceuticals, Inc. | 2020-01-31 | Added / first present |
| Prestige Consumer Healthcare Inc. | Prestige Consumer Healthcare Inc. | 2020-01-31 | Added / first present |
| Endo International PLC | Endo International PLC | 2020-01-31 | Added / first present |
| Taro Pharmaceutical Industries Ltd. | Taro Pharmaceutical Industries Ltd. | 2020-01-31 | Added / first present |
| Perrigo Co. PLC | Perrigo Co. PLC | 2020-01-31 | Added / first present |
| Horizon Therapeutics PLC | Horizon Therapeutics PLC | 2020-01-31 | Added / first present |
Removals
| Ticker | Issuer | Observed date | Change |
|---|---|---|---|
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2026-04-30 | Removed / first absent |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2026-01-31 | Removed / first absent |
| Madrigal Pharmaceuticals, Inc. | Madrigal Pharmaceuticals, Inc. | 2026-04-30 | Removed / first absent |
| CorMedix Inc. | CorMedix Inc. | 2026-01-31 | Removed / first absent |
| Akebia Therapeutics, Inc. | Akebia Therapeutics, Inc. | 2026-01-31 | Removed / first absent |
| Vertex Pharmaceuticals Inc. | Vertex Pharmaceuticals Inc. | 2026-01-31 | Removed / first absent |
| Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | 2025-10-31 | Removed / first absent |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2025-10-31 | Removed / first absent |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2025-10-31 | Removed / first absent |
| Repligen Corp. | Repligen Corp. | 2025-10-31 | Removed / first absent |
| Anavex Life Sciences Corp. | Anavex Life Sciences Corp. | 2025-10-31 | Removed / first absent |
| Dynavax Technologies Corp. | Dynavax Technologies Corp. | 2026-04-30 | Removed / first absent |
| Exact Sciences Corp. | Exact Sciences Corp. | 2026-01-31 | Removed / first absent |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2025-04-30 | Removed / first absent |
| Axsome Therapeutics, Inc. | Axsome Therapeutics, Inc. | 2025-04-30 | Removed / first absent |
| Qiagen N.V. | Qiagen N.V. | 2026-01-31 | Removed / first absent |
| Biogen Inc. | Biogen Inc. | 2025-07-31 | Removed / first absent |
| Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | 2025-01-31 | Removed / first absent |
| Natera, Inc. | Natera, Inc. | 2025-07-31 | Removed / first absent |
| CareDx, Inc. | CareDx, Inc. | 2025-10-31 | Removed / first absent |
| Novavax, Inc. | Novavax, Inc. | 2025-01-31 | Removed / first absent |
| Protagonist Therapeutics, Inc. | Protagonist Therapeutics, Inc. | 2025-10-31 | Removed / first absent |
| Sage Therapeutics, Inc. | Sage Therapeutics, Inc. | 2024-10-31 | Removed / first absent |
| Xencor, Inc. | Xencor, Inc. | 2025-07-31 | Removed / first absent |
| Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. | 2024-10-31 | Removed / first absent |
| OPKO Health, Inc. | OPKO Health, Inc. | 2025-01-31 | Removed / first absent |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2024-10-31 | Removed / first absent |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2024-10-31 | Removed / first absent |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2024-07-31 | Removed / first absent |
| Bio-Techne Corp. | Bio-Techne Corp. | 2025-07-31 | Removed / first absent |
| Xenon Pharmaceuticals Inc. | Xenon Pharmaceuticals Inc. | 2024-07-31 | Removed / first absent |
| EyePoint Pharmaceuticals, Inc. | EyePoint Pharmaceuticals, Inc. | 2024-07-31 | Removed / first absent |
| Illumina, Inc. | Illumina, Inc. | 2024-04-30 | Removed / first absent |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2025-07-31 | Removed / first absent |
| ImmunoGen, Inc. | ImmunoGen, Inc. | 2024-04-30 | Removed / first absent |
| TG Therapeutics, Inc. | TG Therapeutics, Inc. | 2025-10-31 | Removed / first absent |
| Celldex Therapeutics, Inc. | Celldex Therapeutics, Inc. | 2024-07-31 | Removed / first absent |
| Qiagen N.V. | Qiagen N.V. | 2025-01-31 | Removed / first absent |
| Incyte Corp. | Incyte Corp. | 2024-01-31 | Removed / first absent |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2024-04-30 | Removed / first absent |
| OPKO Health, Inc. | OPKO Health, Inc. | 2024-04-30 | Removed / first absent |
| Intra-Cellular Therapies, Inc. | Intra-Cellular Therapies, Inc. | 2024-10-31 | Removed / first absent |
| Fulgent Genetics, Inc. | Fulgent Genetics, Inc. | 2024-04-30 | Removed / first absent |
| Illumina, Inc. | Illumina, Inc. | 2023-10-31 | Removed / first absent |
| Viking Therapeutics, Inc. | Viking Therapeutics, Inc. | 2023-10-31 | Removed / first absent |
| TG Therapeutics, Inc. | TG Therapeutics, Inc. | 2023-10-31 | Removed / first absent |
| CymaBay Therapeutics, Inc. | CymaBay Therapeutics, Inc. | 2023-10-31 | Removed / first absent |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2025-07-31 | Removed / first absent |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2024-01-31 | Removed / first absent |
| Qiagen N.V. | Qiagen N.V. | 2024-01-31 | Removed / first absent |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2023-07-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2023-07-31 | Removed / first absent |
| Catalent, Inc. | Catalent, Inc. | 2024-01-31 | Removed / first absent |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2024-10-31 | Removed / first absent |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2023-04-30 | Removed / first absent |
| Avid Bioservices, Inc. | Avid Bioservices, Inc. | 2023-10-31 | Removed / first absent |
| Cassava Sciences, Inc. | Cassava Sciences, Inc. | 2023-07-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2023-01-31 | Removed / first absent |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2024-01-31 | Removed / first absent |
| Vericel Corp. | Vericel Corp. | 2025-01-31 | Removed / first absent |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2023-07-31 | Removed / first absent |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2023-01-31 | Removed / first absent |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2022-10-31 | Removed / first absent |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2022-10-31 | Removed / first absent |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2023-07-31 | Removed / first absent |
| Vertex Pharmaceuticals, Inc. | Vertex Pharmaceuticals, Inc. | 2024-10-31 | Removed / first absent |
| Incyte Corp. | Incyte Corp. | 2023-07-31 | Removed / first absent |
| Acadia Pharmaceuticals, Inc. | Acadia Pharmaceuticals, Inc. | 2024-07-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2022-07-31 | Removed / first absent |
| Xencor, Inc. | Xencor, Inc. | 2024-01-31 | Removed / first absent |
| OPKO Health, Inc. | OPKO Health, Inc. | 2023-01-31 | Removed / first absent |
| ChemoCentryx, Inc. | ChemoCentryx, Inc. | 2022-10-31 | Removed / first absent |
| Enanta Pharmaceuticals, Inc. | Enanta Pharmaceuticals, Inc. | 2023-01-31 | Removed / first absent |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2025-07-31 | Removed / first absent |
| Intellia Therapeutics, Inc. | Intellia Therapeutics, Inc. | 2022-04-30 | Removed / first absent |
| Novavax, Inc. | Novavax, Inc. | 2022-04-30 | Removed / first absent |
| Cytokinetics, Inc. | Cytokinetics, Inc. | 2022-04-30 | Removed / first absent |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2022-04-30 | Removed / first absent |
| Xenon Pharmaceuticals, Inc. | Xenon Pharmaceuticals, Inc. | 2022-07-31 | Removed / first absent |
| Anavex Life Sciences Corp. | Anavex Life Sciences Corp. | 2022-04-30 | Removed / first absent |
| Incyte Corp. | Incyte Corp. | 2022-01-31 | Removed / first absent |
| Dicerna Pharmaceuticals, Inc. | Dicerna Pharmaceuticals, Inc. | 2022-01-31 | Removed / first absent |
| CareDx, Inc. | CareDx, Inc. | 2022-01-31 | Removed / first absent |
| Dynavax Technologies Corp. | Dynavax Technologies Corp. | 2024-10-31 | Removed / first absent |
| Celldex Therapeutics, Inc. | Celldex Therapeutics, Inc. | 2022-04-30 | Removed / first absent |
| Avid Bioservices, Inc. | Avid Bioservices, Inc. | 2022-04-30 | Removed / first absent |
| Prothena Corp. PLC | Prothena Corp. PLC | 2022-10-31 | Removed / first absent |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2024-01-31 | Removed / first absent |
| Biogen, Inc. | Biogen, Inc. | 2024-07-31 | Removed / first absent |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2021-10-31 | Removed / first absent |
| Cardiovascular Systems, Inc. | Cardiovascular Systems, Inc. | 2022-01-31 | Removed / first absent |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2021-10-31 | Removed / first absent |
| Repligen Corp. | Repligen Corp. | 2025-01-31 | Removed / first absent |
| Amgen, Inc. | Amgen, Inc. | 2023-07-31 | Removed / first absent |
| Illumina, Inc. | Illumina, Inc. | 2022-01-31 | Removed / first absent |
| BioMarin Pharmaceutical, Inc. | BioMarin Pharmaceutical, Inc. | 2021-07-31 | Removed / first absent |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2022-07-31 | Removed / first absent |
| Veracyte, Inc. | Veracyte, Inc. | 2021-10-31 | Removed / first absent |
| MannKind Corp. | MannKind Corp. | 2021-07-31 | Removed / first absent |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2022-07-31 | Removed / first absent |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2021-07-31 | Removed / first absent |
| Alexion Pharmaceuticals, Inc. | Alexion Pharmaceuticals, Inc. | 2021-07-31 | Removed / first absent |
| Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | 2021-04-30 | Removed / first absent |
| Blueprint Medicines Corp. | Blueprint Medicines Corp. | 2022-01-31 | Removed / first absent |
| Xencor, Inc. | Xencor, Inc. | 2022-01-31 | Removed / first absent |
| Vericel Corp. | Vericel Corp. | 2022-07-31 | Removed / first absent |
| Five Prime Therapeutics, Inc. | Five Prime Therapeutics, Inc. | 2021-04-30 | Removed / first absent |
| Bio-Techne Corp. | Bio-Techne Corp. | 2022-10-31 | Removed / first absent |
| Catalent, Inc. | Catalent, Inc. | 2022-10-31 | Removed / first absent |
| Repligen Corp. | Repligen Corp. | 2021-04-30 | Removed / first absent |
| Fulgent Genetics, Inc. | Fulgent Genetics, Inc. | 2023-07-31 | Removed / first absent |
| Precigen, Inc. | Precigen, Inc. | 2021-10-31 | Removed / first absent |
| Seagen, Inc. | Seagen, Inc. | 2021-07-31 | Removed / first absent |
| Illumina, Inc. | Illumina, Inc. | 2021-01-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2021-10-31 | Removed / first absent |
| Amicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | 2021-04-30 | Removed / first absent |
| Insmed, Inc. | Insmed, Inc. | 2021-01-31 | Removed / first absent |
| Fate Therapeutics, Inc. | Fate Therapeutics, Inc. | 2021-01-31 | Removed / first absent |
| Sangamo Therapeutics, Inc. | Sangamo Therapeutics, Inc. | 2021-10-31 | Removed / first absent |
| Intellia Therapeutics, Inc. | Intellia Therapeutics, Inc. | 2021-07-31 | Removed / first absent |
| Fluidigm Corp. | Fluidigm Corp. | 2021-01-31 | Removed / first absent |
| Exelixis, Inc. | Exelixis, Inc. | 2021-04-30 | Removed / first absent |
| Invesco Government & Agency Portfolio | Invesco Government & Agency Portfolio | 2022-07-31 | Removed / first absent |
| Pacific Biosciences of California, Inc. | Pacific Biosciences of California, Inc. | 2021-01-31 | Removed / first absent |
| QIAGEN NV | QIAGEN NV | 2023-04-30 | Removed / first absent |
| Alkermes PLC | Alkermes PLC | 2024-04-30 | Removed / first absent |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2021-01-31 | Removed / first absent |
| Sarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | 2020-10-31 | Removed / first absent |
| Nektar Therapeutics | Nektar Therapeutics | 2021-01-31 | Removed / first absent |
| Acceleron Pharma, Inc. | Acceleron Pharma, Inc. | 2021-04-30 | Removed / first absent |
| MyoKardia, Inc. | MyoKardia, Inc. | 2020-10-31 | Removed / first absent |
| OPKO Health, Inc. | OPKO Health, Inc. | 2022-01-31 | Removed / first absent |
| CareDx, Inc. | CareDx, Inc. | 2021-07-31 | Removed / first absent |
| Vericel Corp. | Vericel Corp. | 2020-10-31 | Removed / first absent |
| ImmunoGen, Inc. | ImmunoGen, Inc. | 2020-10-31 | Removed / first absent |
| Vanda Pharmaceuticals, Inc. | Vanda Pharmaceuticals, Inc. | 2020-10-31 | Removed / first absent |
| Compugen Ltd. | Compugen Ltd. | 2020-10-31 | Removed / first absent |
| Vertex Pharmaceuticals, Inc. | Vertex Pharmaceuticals, Inc. | 2021-04-30 | Removed / first absent |
| Neurocrine Biosciences, Inc. | Neurocrine Biosciences, Inc. | 2021-01-31 | Removed / first absent |
| Arena Pharmaceuticals, Inc. | Arena Pharmaceuticals, Inc. | 2020-07-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2020-07-31 | Removed / first absent |
| PTC Therapeutics, Inc. | PTC Therapeutics, Inc. | 2020-07-31 | Removed / first absent |
| Xencor, Inc. | Xencor, Inc. | 2020-10-31 | Removed / first absent |
| Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. | 2023-10-31 | Removed / first absent |
| Cardiovascular Systems, Inc. | Cardiovascular Systems, Inc. | 2020-10-31 | Removed / first absent |
| Coherus Biosciences, Inc. | Coherus Biosciences, Inc. | 2021-04-30 | Removed / first absent |
| REGENXBIO, Inc. | REGENXBIO, Inc. | 2020-07-31 | Removed / first absent |
| Esperion Therapeutics, Inc. | Esperion Therapeutics, Inc. | 2020-07-31 | Removed / first absent |
| Dicerna Pharmaceuticals, Inc. | Dicerna Pharmaceuticals, Inc. | 2021-07-31 | Removed / first absent |
| Akebia Therapeutics, Inc. | Akebia Therapeutics, Inc. | 2021-01-31 | Removed / first absent |
| Intra-Cellular Therapies, Inc. | Intra-Cellular Therapies, Inc. | 2020-07-31 | Removed / first absent |
| Collegium Pharmaceutical, Inc. | Collegium Pharmaceutical, Inc. | 2020-10-31 | Removed / first absent |
| ChemoCentryx, Inc. | ChemoCentryx, Inc. | 2020-07-31 | Removed / first absent |
| Bio-Techne Corp. | Bio-Techne Corp. | 2020-10-31 | Removed / first absent |
| Exelixis, Inc. | Exelixis, Inc. | 2020-07-31 | Removed / first absent |
| Invesco Premier U.S. Government Money Portfolio | Invesco Premier U.S. Government Money Portfolio | 2020-10-31 | Removed / first absent |
| Catalent, Inc. | Catalent, Inc. | 2020-07-31 | Removed / first absent |
| Repligen Corp. | Repligen Corp. | 2020-10-31 | Removed / first absent |
| Emergent BioSolutions, Inc. | Emergent BioSolutions, Inc. | 2023-04-30 | Removed / first absent |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2020-10-31 | Removed / first absent |
| CRISPR Therapeutics AG | CRISPR Therapeutics AG | 2021-01-31 | Removed / first absent |
| Alkermes PLC | Alkermes PLC | 2020-07-31 | Removed / first absent |
| Merck & Co., Inc. | Merck & Co., Inc. | 2020-04-30 | Removed / first absent |
| AbbVie, Inc. | AbbVie, Inc. | 2020-04-30 | Removed / first absent |
| Bristol-Myers Squibb Co. | Bristol-Myers Squibb Co. | 2020-04-30 | Removed / first absent |
| Johnson & Johnson | Johnson & Johnson | 2020-04-30 | Removed / first absent |
| Pfizer, Inc. | Pfizer, Inc. | 2020-04-30 | Removed / first absent |
| Abbott Laboratories | Abbott Laboratories | 2020-04-30 | Removed / first absent |
| Eli Lilly and Co. | Eli Lilly and Co. | 2020-04-30 | Removed / first absent |
| Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Jazz Pharmaceuticals PLC | Jazz Pharmaceuticals PLC | 2020-04-30 | Removed / first absent |
| Bausch Health Cos. Inc. | Bausch Health Cos. Inc. | 2020-04-30 | Removed / first absent |
| Pacira BioSciences, Inc. | Pacira BioSciences, Inc. | 2020-04-30 | Removed / first absent |
| ANI Pharmaceuticals, Inc. | ANI Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Amphastar Pharmaceuticals, Inc. | Amphastar Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Innoviva, Inc. | Innoviva, Inc. | 2020-04-30 | Removed / first absent |
| Supernus Pharmaceuticals, Inc. | Supernus Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Eagle Pharmaceuticals, Inc. | Eagle Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Corcept Therapeutics, Inc. | Corcept Therapeutics, Inc. | 2020-04-30 | Removed / first absent |
| Mylan N.V. | Mylan N.V. | 2020-04-30 | Removed / first absent |
| Ligand Pharmaceuticals, Inc. | Ligand Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Prestige Consumer Healthcare Inc. | Prestige Consumer Healthcare Inc. | 2020-04-30 | Removed / first absent |
| Endo International PLC | Endo International PLC | 2020-04-30 | Removed / first absent |
| Taro Pharmaceutical Industries Ltd. | Taro Pharmaceutical Industries Ltd. | 2020-04-30 | Removed / first absent |
| Perrigo Co. PLC | Perrigo Co. PLC | 2020-04-30 | Removed / first absent |
| Horizon Therapeutics PLC | Horizon Therapeutics PLC | 2020-04-30 | Removed / first absent |
| Vertex Pharmaceuticals, Inc. | Vertex Pharmaceuticals, Inc. | 2020-01-31 | Removed / first absent |
| Gilead Sciences, Inc. | Gilead Sciences, Inc. | 2021-01-31 | Removed / first absent |
| Biogen, Inc. | Biogen, Inc. | 2021-04-30 | Removed / first absent |
| Amgen, Inc. | Amgen, Inc. | 2021-01-31 | Removed / first absent |
| Celgene Corp. | Celgene Corp. | 2020-01-31 | Removed / first absent |
| Alexion Pharmaceuticals, Inc. | Alexion Pharmaceuticals, Inc. | 2020-07-31 | Removed / first absent |
| Incyte Corp. | Incyte Corp. | 2020-01-31 | Removed / first absent |
| Nektar Therapeutics | Nektar Therapeutics | 2020-01-31 | Removed / first absent |
| Neurocrine Biosciences, Inc. | Neurocrine Biosciences, Inc. | 2020-01-31 | Removed / first absent |
| United Therapeutics Corp. | United Therapeutics Corp. | 2020-01-31 | Removed / first absent |
| Portola Pharmaceuticals, Inc. | Portola Pharmaceuticals, Inc. | 2020-01-31 | Removed / first absent |
| Arena Pharmaceuticals, Inc. | Arena Pharmaceuticals, Inc. | 2020-01-31 | Removed / first absent |
| Halozyme Therapeutics, Inc. | Halozyme Therapeutics, Inc. | 2020-01-31 | Removed / first absent |
| FibroGen, Inc. | FibroGen, Inc. | 2020-01-31 | Removed / first absent |
| Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | 2020-01-31 | Removed / first absent |
| Natera, Inc. | Natera, Inc. | 2020-01-31 | Removed / first absent |
| Xencor, Inc. | Xencor, Inc. | 2020-01-31 | Removed / first absent |
| Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. | 2020-01-31 | Removed / first absent |
| Coherus Biosciences, Inc. | Coherus Biosciences, Inc. | 2020-01-31 | Removed / first absent |
| Radius Health, Inc. | Radius Health, Inc. | 2020-01-31 | Removed / first absent |
| Veracyte, Inc. | Veracyte, Inc. | 2020-01-31 | Removed / first absent |
| Voyager Therapeutics, Inc. | Voyager Therapeutics, Inc. | 2020-01-31 | Removed / first absent |
| Exelixis, Inc. | Exelixis, Inc. | 2020-01-31 | Removed / first absent |
| Invesco Government & Agency Portfolio | Invesco Government & Agency Portfolio | 2020-04-30 | Removed / first absent |
| Invesco Liquid Assets Portfolio | Invesco Liquid Assets Portfolio | 2020-04-30 | Removed / first absent |
| Enanta Pharmaceuticals, Inc. | Enanta Pharmaceuticals, Inc. | 2020-07-31 | Removed / first absent |
| Invesco Premier U.S. Government Money Portfolio | Invesco Premier U.S. Government Money Portfolio | 2020-01-31 | Removed / first absent |
| Repligen Corp. | Repligen Corp. | 2020-01-31 | Removed / first absent |
| Emergent BioSolutions, Inc. | Emergent BioSolutions, Inc. | 2020-01-31 | Removed / first absent |
| Myriad Genetics, Inc. | Myriad Genetics, Inc. | 2020-01-31 | Removed / first absent |
| Genomic Health, Inc. | Genomic Health, Inc. | 2020-01-31 | Removed / first absent |
| Vanda Pharmaceuticals, Inc. | Vanda Pharmaceuticals, Inc. | 2020-04-30 | Removed / first absent |
| Alkermes PLC | Alkermes PLC | 2020-01-31 | Removed / first absent |