IYH additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| MEDLINE INC. | MEDLINE INC. | 2026-04-30 | Added / first present |
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| HOLOGIC INC CVR | HOLOGIC INC CVR | 2026-04-30 | Added / first present |
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| 1XAVM26 | XAV HEALTH CARE JUN26 | 2026-04-30 | Added / first present |
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| Qiagen N.V. | Qiagen N.V. | 2026-01-31 | Added / first present |
|---|
| 1XAVH26 | XAV HEALTH CARE MAR26 | 2026-01-31 | Added / first present |
|---|
| CARIS LIFE SCIENCES, INC. | CARIS LIFE SCIENCES, INC. | 2025-10-31 | Added / first present |
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| 1XAVZ25 | XAV HEALTH CARE DEC25 | 2025-10-31 | Added / first present |
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| HALOZYME THERAPEUTICS, INC. | HALOZYME THERAPEUTICS, INC. | 2025-07-31 | Added / first present |
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| INSMED INCORPORATED | INSMED INCORPORATED | 2025-07-31 | Added / first present |
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| CORCEPT THERAPEUTICS INCORPORATED | CORCEPT THERAPEUTICS INCORPORATED | 2025-07-31 | Added / first present |
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| Revolution Medicines Inc | Revolution Medicines Inc | 2025-07-31 | Added / first present |
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| Summit Therapeutics Inc | Summit Therapeutics Inc | 2025-07-31 | Added / first present |
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| TEMPUS AI, INC. | TEMPUS AI, INC. | 2025-07-31 | Added / first present |
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| 1XAVU25 | XAV HEALTH CARE SEP25 | 2025-07-31 | Added / first present |
|---|
| 1XAVM25 | XAV HEALTH CARE JUN25 | 2025-04-30 | Added / first present |
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| Qiagen N.V. | Qiagen N.V. | 2025-01-31 | Added / first present |
|---|
| 1XAVH25 | XAV HEALTH CARE MAR25 | 2025-01-31 | Added / first present |
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| WATERS CORPORATION | WATERS CORPORATION | 2024-10-31 | Added / first present |
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| 1XAVZ24 | XAV HEALTH CARE DEC24 | 2024-10-31 | Added / first present |
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| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2024-07-31 | Added / first present |
|---|
| Viking Therapeutics Inc | Viking Therapeutics Inc | 2024-07-31 | Added / first present |
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| CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | 2024-07-31 | Added / first present |
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| LABCORP HOLDINGS INC. | LABCORP HOLDINGS INC. | 2024-07-31 | Added / first present |
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| Grail Inc | Grail Inc | 2024-07-31 | Added / first present |
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| 1XAVU24 | XAV HEALTH CARE SEP24 | 2024-07-31 | Added / first present |
|---|
| THE COOPER COMPANIES, INC. | THE COOPER COMPANIES, INC. | 2024-04-30 | Added / first present |
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| SOLVENTUM CORPORATION | SOLVENTUM CORPORATION | 2024-04-30 | Added / first present |
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| 1XAVM24 | XAV HEALTH CARE JUN24 | 2024-04-30 | Added / first present |
|---|
| Qiagen N.V. | Qiagen N.V. | 2024-01-31 | Added / first present |
|---|
| IXCH4 | XAV HEALTH CARE MAR24 | 2024-01-31 | Added / first present |
|---|
| IXCZ3 | XAV HEALTH CARE DEC23 | 2023-10-31 | Added / first present |
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| APELLIS PHARMACEUTICALS, INC. | APELLIS PHARMACEUTICALS, INC. | 2023-07-31 | Added / first present |
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| Inspire Medical Systems Inc | Inspire Medical Systems Inc | 2023-07-31 | Added / first present |
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| MEDPACE HOLDINGS, INC. | MEDPACE HOLDINGS, INC. | 2023-07-31 | Added / first present |
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| ICON PUBLIC LIMITED COMPANY | ICON PUBLIC LIMITED COMPANY | 2023-07-31 | Added / first present |
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| Karuna Therapeutics Inc | Karuna Therapeutics Inc | 2023-07-31 | Added / first present |
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| SHOCKWAVE MEDICAL, INC. | SHOCKWAVE MEDICAL, INC. | 2023-07-31 | Added / first present |
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| Roivant Sciences Ltd | Roivant Sciences Ltd | 2023-07-31 | Added / first present |
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| R1 RCM HOLDCO INC. | R1 RCM HOLDCO INC. | 2023-07-31 | Added / first present |
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| FORTREA HOLDINGS INC. | FORTREA HOLDINGS INC. | 2023-07-31 | Added / first present |
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| IXCU3 | XAV HEALTH CARE SEP23 | 2023-07-31 | Added / first present |
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| IXCM3 | XAV HEALTH CARE JUN23 | 2023-04-30 | Added / first present |
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| Azenta, Inc. | Azenta, Inc. | 2023-01-31 | Added / first present |
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| GE HEALTHCARE TECHNOLOGIES INC. | GE HEALTHCARE TECHNOLOGIES INC. | 2023-01-31 | Added / first present |
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| IXCH3 | XAV HEALTH CARE MAR23 | 2023-01-31 | Added / first present |
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| IXCZ2 | XAV HEALTH CARE DEC22 | 2022-10-31 | Added / first present |
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| STERIS PUBLIC LIMITED COMPANY | STERIS PUBLIC LIMITED COMPANY | 2022-07-31 | Added / first present |
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| JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY | JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2022-07-31 | Added / first present |
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| TENET HEALTHCARE CORPORATION | TENET HEALTHCARE CORPORATION | 2022-07-31 | Added / first present |
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| MEDTRONIC PUBLIC LIMITED COMPANY | MEDTRONIC PUBLIC LIMITED COMPANY | 2022-07-31 | Added / first present |
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| Qiagen N.V. | Qiagen N.V. | 2022-07-31 | Added / first present |
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| PERRIGO COMPANY PUBLIC LIMITED COMPANY | PERRIGO COMPANY PUBLIC LIMITED COMPANY | 2022-07-31 | Added / first present |
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| HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY | HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY | 2022-07-31 | Added / first present |
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| NOVOCURE LIMITED | NOVOCURE LIMITED | 2022-07-31 | Added / first present |
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| ROYALTY PHARMA PLC | ROYALTY PHARMA PLC | 2022-07-31 | Added / first present |
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| Doximity Inc | Doximity Inc | 2022-07-31 | Added / first present |
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| Ginkgo Bioworks Holdings Inc | Ginkgo Bioworks Holdings Inc | 2022-07-31 | Added / first present |
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| QUIDELORTHO CORPORATION | QUIDELORTHO CORPORATION | 2022-07-31 | Added / first present |
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| Enhabit Inc | Enhabit Inc | 2022-07-31 | Added / first present |
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| IXCU2 | XAV HEALTH CARE SEP22 | 2022-07-31 | Added / first present |
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| Embecta Corp | Embecta Corp | 2022-04-30 | Added / first present |
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| Zimvie Inc | Zimvie Inc | 2022-04-30 | Added / first present |
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| Enovis Corp | Enovis Corp | 2022-04-30 | Added / first present |
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| Definitive Healthcare Corp | Definitive Healthcare Corp | 2022-01-31 | Added / first present |
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| Cerner Corp | Cerner Corp | 2021-10-31 | Added / first present |
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| Veeva Systems Inc | Veeva Systems Inc | 2021-10-31 | Added / first present |
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| Cardinal Health Inc | Cardinal Health Inc | 2021-10-31 | Added / first present |
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| Sage Therapeutics Inc | Sage Therapeutics Inc | 2021-10-31 | Added / first present |
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| Envista Holdings Corp | Envista Holdings Corp | 2021-10-31 | Added / first present |
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| Mirati Therapeutics Inc | Mirati Therapeutics Inc | 2021-10-31 | Added / first present |
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| Iovance Biotherapeutics Inc | Iovance Biotherapeutics Inc | 2021-10-31 | Added / first present |
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| Natera Inc | Natera Inc | 2021-10-31 | Added / first present |
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| PerkinElmer Inc | PerkinElmer Inc | 2021-10-31 | Added / first present |
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| Adaptive Biotechnologies Corp | Adaptive Biotechnologies Corp | 2021-10-31 | Added / first present |
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| Certara Inc | Certara Inc | 2021-10-31 | Added / first present |
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| agilon health Inc | agilon health Inc | 2021-10-31 | Added / first present |
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| Sotera Health Co | Sotera Health Co | 2021-07-31 | Added / first present |
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| Maravai LifeSciences Holdings Inc | Maravai LifeSciences Holdings Inc | 2021-07-31 | Added / first present |
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| Signify Health Inc | Signify Health Inc | 2021-07-31 | Added / first present |
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| Organon & Co | Organon & Co | 2021-07-31 | Added / first present |
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| GoodRx Holdings Inc | GoodRx Holdings Inc | 2021-04-30 | Added / first present |
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| American Well Corp | American Well Corp | 2021-04-30 | Added / first present |
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| Atea Pharmaceuticals Inc | Atea Pharmaceuticals Inc | 2021-04-30 | Added / first present |
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| Oak Street Health Inc | Oak Street Health Inc | 2021-01-31 | Added / first present |
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| Berkeley Lights Inc | Berkeley Lights Inc | 2021-01-31 | Added / first present |
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| Viatris Inc | Viatris Inc | 2021-01-31 | Added / first present |
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| LHC Group Inc | LHC Group Inc | 2020-10-31 | Added / first present |
|---|
| Acceleron Pharma Inc | Acceleron Pharma Inc | 2020-10-31 | Added / first present |
|---|
| Tandem Diabetes Care Inc | Tandem Diabetes Care Inc | 2020-10-31 | Added / first present |
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| Quidel Corp | Quidel Corp | 2020-10-31 | Added / first present |
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| Novavax Inc | Novavax Inc | 2020-10-31 | Added / first present |
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| Emergent BioSolutions Inc | Emergent BioSolutions Inc | 2020-10-31 | Added / first present |
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| Seagen Inc | Seagen Inc | 2020-10-31 | Added / first present |
|---|
| 10X Genomics Inc | 10X Genomics Inc | 2020-07-31 | Added / first present |
|---|
| 1Life Healthcare Inc | 1Life Healthcare Inc | 2020-07-31 | Added / first present |
|---|
| Vir Biotechnology Inc | Vir Biotechnology Inc | 2020-07-31 | Added / first present |
|---|
| PPD Inc | PPD Inc | 2020-07-31 | Added / first present |
|---|
Removals
| Ticker | Issuer | Observed date | Change |
|---|
| 1XAVH26 | XAV HEALTH CARE MAR26 | 2026-04-30 | Removed / first absent |
|---|
| 1XAVZ25 | XAV HEALTH CARE DEC25 | 2026-01-31 | Removed / first absent |
|---|
| 1XAVU25 | XAV HEALTH CARE SEP25 | 2025-10-31 | Removed / first absent |
|---|
| 1XAVM25 | XAV HEALTH CARE JUN25 | 2025-07-31 | Removed / first absent |
|---|
| Qiagen N.V. | Qiagen N.V. | 2026-01-31 | Removed / first absent |
|---|
| 1XAVH25 | XAV HEALTH CARE MAR25 | 2025-04-30 | Removed / first absent |
|---|
| 1XAVZ24 | XAV HEALTH CARE DEC24 | 2025-01-31 | Removed / first absent |
|---|
| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2025-04-30 | Removed / first absent |
|---|
| CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | 2024-10-31 | Removed / first absent |
|---|
| Grail Inc | Grail Inc | 2025-07-31 | Removed / first absent |
|---|
| 1XAVU24 | XAV HEALTH CARE SEP24 | 2024-10-31 | Removed / first absent |
|---|
| 1XAVM24 | XAV HEALTH CARE JUN24 | 2024-07-31 | Removed / first absent |
|---|
| Qiagen N.V. | Qiagen N.V. | 2025-01-31 | Removed / first absent |
|---|
| IXCH4 | XAV HEALTH CARE MAR24 | 2024-04-30 | Removed / first absent |
|---|
| IXCZ3 | XAV HEALTH CARE DEC23 | 2024-01-31 | Removed / first absent |
|---|
| ICON PUBLIC LIMITED COMPANY | ICON PUBLIC LIMITED COMPANY | 2024-07-31 | Removed / first absent |
|---|
| Karuna Therapeutics Inc | Karuna Therapeutics Inc | 2024-04-30 | Removed / first absent |
|---|
| SHOCKWAVE MEDICAL, INC. | SHOCKWAVE MEDICAL, INC. | 2024-07-31 | Removed / first absent |
|---|
| R1 RCM HOLDCO INC. | R1 RCM HOLDCO INC. | 2025-01-31 | Removed / first absent |
|---|
| FORTREA HOLDINGS INC. | FORTREA HOLDINGS INC. | 2025-07-31 | Removed / first absent |
|---|
| IXCU3 | XAV HEALTH CARE SEP23 | 2023-10-31 | Removed / first absent |
|---|
| IXCM3 | XAV HEALTH CARE JUN23 | 2023-07-31 | Removed / first absent |
|---|
| Azenta, Inc. | Azenta, Inc. | 2025-07-31 | Removed / first absent |
|---|
| IXCH3 | XAV HEALTH CARE MAR23 | 2023-04-30 | Removed / first absent |
|---|
| IXCZ2 | XAV HEALTH CARE DEC22 | 2023-01-31 | Removed / first absent |
|---|
| Qiagen N.V. | Qiagen N.V. | 2024-01-31 | Removed / first absent |
|---|
| HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY | HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY | 2023-10-31 | Removed / first absent |
|---|
| NOVOCURE LIMITED | NOVOCURE LIMITED | 2024-07-31 | Removed / first absent |
|---|
| Ginkgo Bioworks Holdings Inc | Ginkgo Bioworks Holdings Inc | 2024-07-31 | Removed / first absent |
|---|
| QUIDELORTHO CORPORATION | QUIDELORTHO CORPORATION | 2025-07-31 | Removed / first absent |
|---|
| Enhabit Inc | Enhabit Inc | 2023-07-31 | Removed / first absent |
|---|
| IXCU2 | XAV HEALTH CARE SEP22 | 2022-10-31 | Removed / first absent |
|---|
| Embecta Corp | Embecta Corp | 2022-07-31 | Removed / first absent |
|---|
| Zimvie Inc | Zimvie Inc | 2022-07-31 | Removed / first absent |
|---|
| Enovis Corp | Enovis Corp | 2025-07-31 | Removed / first absent |
|---|
| Definitive Healthcare Corp | Definitive Healthcare Corp | 2022-07-31 | Removed / first absent |
|---|
| Cerner Corp | Cerner Corp | 2022-07-31 | Removed / first absent |
|---|
| Sage Therapeutics Inc | Sage Therapeutics Inc | 2022-07-31 | Removed / first absent |
|---|
| Mirati Therapeutics Inc | Mirati Therapeutics Inc | 2024-01-31 | Removed / first absent |
|---|
| Iovance Biotherapeutics Inc | Iovance Biotherapeutics Inc | 2022-07-31 | Removed / first absent |
|---|
| Adaptive Biotechnologies Corp | Adaptive Biotechnologies Corp | 2022-07-31 | Removed / first absent |
|---|
| agilon health Inc | agilon health Inc | 2024-07-31 | Removed / first absent |
|---|
| Maravai LifeSciences Holdings Inc | Maravai LifeSciences Holdings Inc | 2024-07-31 | Removed / first absent |
|---|
| Signify Health Inc | Signify Health Inc | 2023-04-30 | Removed / first absent |
|---|
| GoodRx Holdings Inc | GoodRx Holdings Inc | 2021-10-31 | Removed / first absent |
|---|
| American Well Corp | American Well Corp | 2021-10-31 | Removed / first absent |
|---|
| Atea Pharmaceuticals Inc | Atea Pharmaceuticals Inc | 2021-10-31 | Removed / first absent |
|---|
| Oak Street Health Inc | Oak Street Health Inc | 2023-07-31 | Removed / first absent |
|---|
| Berkeley Lights Inc | Berkeley Lights Inc | 2021-10-31 | Removed / first absent |
|---|
| LHC Group Inc | LHC Group Inc | 2021-10-31 | Removed / first absent |
|---|
| Acceleron Pharma Inc | Acceleron Pharma Inc | 2022-01-31 | Removed / first absent |
|---|
| Tandem Diabetes Care Inc | Tandem Diabetes Care Inc | 2024-07-31 | Removed / first absent |
|---|
| Quidel Corp | Quidel Corp | 2022-07-31 | Removed / first absent |
|---|
| Novavax Inc | Novavax Inc | 2023-07-31 | Removed / first absent |
|---|
| Emergent BioSolutions Inc | Emergent BioSolutions Inc | 2021-10-31 | Removed / first absent |
|---|
| Seagen Inc | Seagen Inc | 2024-01-31 | Removed / first absent |
|---|
| 10X Genomics Inc | 10X Genomics Inc | 2025-07-31 | Removed / first absent |
|---|
| 1Life Healthcare Inc | 1Life Healthcare Inc | 2021-10-31 | Removed / first absent |
|---|
| Vir Biotechnology Inc | Vir Biotechnology Inc | 2021-10-31 | Removed / first absent |
|---|
| PPD Inc | PPD Inc | 2022-01-31 | Removed / first absent |
|---|
| Chicago Mercantile Exchange | Chicago Mercantile Exchange | 2022-07-31 | Removed / first absent |
|---|
| McKesson Corp | McKesson Corp | 2021-10-31 | Removed / first absent |
|---|
| Laboratory Corp of America Holdings | Laboratory Corp of America Holdings | 2024-07-31 | Removed / first absent |
|---|
| Mettler-Toledo International Inc | Mettler-Toledo International Inc | 2021-10-31 | Removed / first absent |
|---|
| WellCare Health Plans Inc | WellCare Health Plans Inc | 2020-01-31 | Removed / first absent |
|---|
| Waters Corp | Waters Corp | 2021-10-31 | Removed / first absent |
|---|
| Cooper Cos Inc/The | Cooper Cos Inc/The | 2024-04-30 | Removed / first absent |
|---|
| Varian Medical Systems Inc | Varian Medical Systems Inc | 2021-04-30 | Removed / first absent |
|---|
| CVS Health Corp | CVS Health Corp | 2021-10-31 | Removed / first absent |
|---|
| Celgene Corp | Celgene Corp | 2020-01-31 | Removed / first absent |
|---|
| Alexion Pharmaceuticals Inc | Alexion Pharmaceuticals Inc | 2021-07-31 | Removed / first absent |
|---|
| Seattle Genetics Inc | Seattle Genetics Inc | 2020-10-31 | Removed / first absent |
|---|
| Exact Sciences Corp | Exact Sciences Corp | 2026-04-30 | Removed / first absent |
|---|
| ABIOMED Inc | ABIOMED Inc | 2023-01-31 | Removed / first absent |
|---|
| Nektar Therapeutics | Nektar Therapeutics | 2022-07-31 | Removed / first absent |
|---|
| Sage Therapeutics Inc | Sage Therapeutics Inc | 2020-10-31 | Removed / first absent |
|---|
| Bluebird Bio Inc | Bluebird Bio Inc | 2021-10-31 | Removed / first absent |
|---|
| MEDNAX Inc | MEDNAX Inc | 2020-10-31 | Removed / first absent |
|---|
| Agios Pharmaceuticals Inc | Agios Pharmaceuticals Inc | 2021-10-31 | Removed / first absent |
|---|
| Premier Inc | Premier Inc | 2025-07-31 | Removed / first absent |
|---|
| Portola Pharmaceuticals Inc | Portola Pharmaceuticals Inc | 2020-07-31 | Removed / first absent |
|---|
| ACADIA Pharmaceuticals Inc | ACADIA Pharmaceuticals Inc | 2021-10-31 | Removed / first absent |
|---|
| Teladoc Health Inc | Teladoc Health Inc | 2024-07-31 | Removed / first absent |
|---|
| Amedisys Inc | Amedisys Inc | 2025-10-31 | Removed / first absent |
|---|
| Allogene Therapeutics Inc | Allogene Therapeutics Inc | 2021-10-31 | Removed / first absent |
|---|
| Blueprint Medicines Corp | Blueprint Medicines Corp | 2021-10-31 | Removed / first absent |
|---|
| Guardant Health Inc | Guardant Health Inc | 2023-07-31 | Removed / first absent |
|---|
| Syneos Health Inc | Syneos Health Inc | 2023-10-31 | Removed / first absent |
|---|
| Medicines Co/The | Medicines Co/The | 2020-01-31 | Removed / first absent |
|---|
| FibroGen Inc | FibroGen Inc | 2021-10-31 | Removed / first absent |
|---|
| Immunomedics Inc | Immunomedics Inc | 2020-10-31 | Removed / first absent |
|---|
| Tenet Healthcare Corp | Tenet Healthcare Corp | 2021-10-31 | Removed / first absent |
|---|
| Intercept Pharmaceuticals Inc | Intercept Pharmaceuticals Inc | 2020-10-31 | Removed / first absent |
|---|
| Hologic Inc | Hologic Inc | 2026-04-30 | Removed / first absent |
|---|
| Hill-Rom Holdings Inc | Hill-Rom Holdings Inc | 2022-01-31 | Removed / first absent |
|---|
| PRA Health Sciences Inc | PRA Health Sciences Inc | 2021-07-31 | Removed / first absent |
|---|
| Covetrus Inc | Covetrus Inc | 2021-10-31 | Removed / first absent |
|---|
| Integra LifeSciences Holdings | Integra LifeSciences Holdings | 2024-07-31 | Removed / first absent |
|---|
| Cantel Medical Corp | Cantel Medical Corp | 2020-10-31 | Removed / first absent |
|---|
| Catalent Inc | Catalent Inc | 2025-01-31 | Removed / first absent |
|---|
| Haemonetics Corp | Haemonetics Corp | 2021-10-31 | Removed / first absent |
|---|
| HealthEquity Inc | HealthEquity Inc | 2021-10-31 | Removed / first absent |
|---|
| NuVasive Inc | NuVasive Inc | 2021-10-31 | Removed / first absent |
|---|
| ICU Medical Inc | ICU Medical Inc | 2024-07-31 | Removed / first absent |
|---|
| AVANOS MEDICAL INC | AVANOS MEDICAL INC | 2020-10-31 | Removed / first absent |
|---|
| Neogen Corp | Neogen Corp | 2021-10-31 | Removed / first absent |
|---|
| Myriad Genetics Inc | Myriad Genetics Inc | 2020-10-31 | Removed / first absent |
|---|