IHE additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| Alumis Inc | Alumis Inc | 2026-03-31 | Added / first present |
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| BIOAGE Labs Inc | BIOAGE Labs Inc | 2026-03-31 | Added / first present |
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| LB Pharmaceuticals Inc | LB Pharmaceuticals Inc | 2026-03-31 | Added / first present |
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| INDIVIOR PHARMACEUTICALS, INC. | INDIVIOR PHARMACEUTICALS, INC. | 2026-03-31 | Added / first present |
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| Definium Therapeutics Inc | Definium Therapeutics Inc | 2026-03-31 | Added / first present |
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| 1XAVM26 | XAV HEALTH CARE JUN26 | 2026-03-31 | Added / first present |
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| OMEROS CORPORATION | OMEROS CORPORATION | 2025-12-31 | Added / first present |
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| CORMEDIX INC. | CORMEDIX INC. | 2025-12-31 | Added / first present |
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| Trevi Therapeutics Inc | Trevi Therapeutics Inc | 2025-12-31 | Added / first present |
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| EYEPOINT, INC. | EYEPOINT, INC. | 2025-12-31 | Added / first present |
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| Terns Pharmaceuticals Inc | Terns Pharmaceuticals Inc | 2025-12-31 | Added / first present |
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| XERIS BIOPHARMA HOLDINGS, INC. | XERIS BIOPHARMA HOLDINGS, INC. | 2025-12-31 | Added / first present |
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| Ventyx Biosciences Inc | Ventyx Biosciences Inc | 2025-12-31 | Added / first present |
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| INDIVIOR PLC | INDIVIOR PLC | 2025-12-31 | Added / first present |
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| Rapport Therapeutics Inc | Rapport Therapeutics Inc | 2025-12-31 | Added / first present |
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| Septerna Inc | Septerna Inc | 2025-12-31 | Added / first present |
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| MBX Biosciences Inc | MBX Biosciences Inc | 2025-12-31 | Added / first present |
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| Maze Therapeutics Inc | Maze Therapeutics Inc | 2025-12-31 | Added / first present |
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| 1XAVH26 | XAV HEALTH CARE MAR26 | 2025-12-31 | Added / first present |
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| PHIBRO ANIMAL HEALTH CORPORATION | PHIBRO ANIMAL HEALTH CORPORATION | 2025-09-30 | Added / first present |
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| Crinetics Pharmaceuticals Inc | Crinetics Pharmaceuticals Inc | 2025-09-30 | Added / first present |
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| PHATHOM PHARMACEUTICALS, INC. | PHATHOM PHARMACEUTICALS, INC. | 2025-09-30 | Added / first present |
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| Amylyx Pharmaceuticals Inc | Amylyx Pharmaceuticals Inc | 2025-09-30 | Added / first present |
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| LENZ Therapeutics Inc | LENZ Therapeutics Inc | 2025-09-30 | Added / first present |
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| AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2025-09-30 | Added / first present |
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| NEKTAR THERAPEUTICS | NEKTAR THERAPEUTICS | 2025-09-30 | Added / first present |
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| 1XAVZ25 | XAV HEALTH CARE DEC25 | 2025-09-30 | Added / first present |
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| 1XAVU25 | XAV HEALTH CARE SEP25 | 2025-06-30 | Added / first present |
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| 1XAVM25 | XAV HEALTH CARE JUN25 | 2025-03-31 | Added / first present |
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| OMEROS CORPORATION | OMEROS CORPORATION | 2024-12-31 | Added / first present |
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| Evolus Inc | Evolus Inc | 2024-12-31 | Added / first present |
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| OCULAR THERAPEUTIX, INC. | OCULAR THERAPEUTIX, INC. | 2024-12-31 | Added / first present |
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| HARROW, INC. | HARROW, INC. | 2024-12-31 | Added / first present |
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| Liquidia Corp | Liquidia Corp | 2024-12-31 | Added / first present |
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| WAVE Life Sciences Ltd | WAVE Life Sciences Ltd | 2024-12-31 | Added / first present |
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| 1XAVH25 | XAV HEALTH CARE MAR25 | 2024-12-31 | Added / first present |
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| PHATHOM PHARMACEUTICALS, INC. | PHATHOM PHARMACEUTICALS, INC. | 2024-09-30 | Added / first present |
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| Neumora Therapeutics Inc | Neumora Therapeutics Inc | 2024-09-30 | Added / first present |
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| 1XAVZ24 | XAV HEALTH CARE DEC24 | 2024-09-30 | Added / first present |
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| Nuvation Bio Inc | Nuvation Bio Inc | 2024-06-30 | Added / first present |
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| Mind Medicine (MindMed) Inc | Mind Medicine (MindMed) Inc | 2024-06-30 | Added / first present |
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| Enliven Therapeutics Inc | Enliven Therapeutics Inc | 2024-06-30 | Added / first present |
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| 1XAVU24 | XAV HEALTH CARE SEP24 | 2024-06-30 | Added / first present |
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| AMNEAL PHARMACEUTICALS, INC. | AMNEAL PHARMACEUTICALS, INC. | 2024-03-31 | Added / first present |
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| Tarsus Pharmaceuticals Inc | Tarsus Pharmaceuticals Inc | 2024-03-31 | Added / first present |
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| Edgewise Therapeutics Inc | Edgewise Therapeutics Inc | 2024-03-31 | Added / first present |
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| 1XAVM24 | XAV HEALTH CARE JUN24 | 2024-03-31 | Added / first present |
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| CASSAVA SCIENCES INC | CASSAVA SCIENCES INC | 2023-12-31 | Added / first present |
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| CymaBay Therapeutics Inc | CymaBay Therapeutics Inc | 2023-12-31 | Added / first present |
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| ANI PHARMACEUTICALS, INC. | ANI PHARMACEUTICALS, INC. | 2023-12-31 | Added / first present |
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| IXCH4 | XAV HEALTH CARE MAR24 | 2023-12-31 | Added / first present |
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| SUPERNUS PHARMACEUTICALS, INC. | SUPERNUS PHARMACEUTICALS, INC. | 2023-09-30 | Added / first present |
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| IXCZ3 | XAV HEALTH CARE DEC23 | 2023-09-30 | Added / first present |
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| BlackRock Funds III: BlackRock Cash Funds: Treasury; SL Agency Shares | BlackRock Funds III: BlackRock Cash Funds: Treasury; SL Agency Shares | 2023-06-30 | Added / first present |
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| IXCU3 | XAV HEALTH CARE SEP23 | 2023-06-30 | Added / first present |
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| IXCM3 | XAV HEALTH CARE JUN23 | 2023-03-31 | Added / first present |
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| Aclaris Therapeutics Inc | Aclaris Therapeutics Inc | 2022-12-31 | Added / first present |
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| LIGAND PHARMACEUTICALS INCORPORATED | LIGAND PHARMACEUTICALS INCORPORATED | 2022-12-31 | Added / first present |
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| Dice Therapeutics Inc | Dice Therapeutics Inc | 2022-12-31 | Added / first present |
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| Ventyx Biosciences Inc | Ventyx Biosciences Inc | 2022-12-31 | Added / first present |
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| IXCH3 | XAV HEALTH CARE MAR23 | 2022-12-31 | Added / first present |
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| JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY | JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2022-09-30 | Added / first present |
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| PERRIGO COMPANY PUBLIC LIMITED COMPANY | PERRIGO COMPANY PUBLIC LIMITED COMPANY | 2022-09-30 | Added / first present |
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| THERAVANCE BIOPHARMA, INC. | THERAVANCE BIOPHARMA, INC. | 2022-09-30 | Added / first present |
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| ROYALTY PHARMA PLC | ROYALTY PHARMA PLC | 2022-09-30 | Added / first present |
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| Pliant Therapeutics Inc | Pliant Therapeutics Inc | 2022-09-30 | Added / first present |
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| CinCor Pharma Inc | CinCor Pharma Inc | 2022-09-30 | Added / first present |
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| Amylyx Pharmaceuticals Inc | Amylyx Pharmaceuticals Inc | 2022-09-30 | Added / first present |
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| IXCZ2 | XAV HEALTH CARE DEC22 | 2022-09-30 | Added / first present |
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| Cassava Sciences Inc | Cassava Sciences Inc | 2021-12-31 | Added / first present |
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| Harmony Biosciences Holdings Inc | Harmony Biosciences Holdings Inc | 2021-12-31 | Added / first present |
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| Antares Pharma Inc | Antares Pharma Inc | 2021-06-30 | Added / first present |
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| Nuvation Bio Inc | Nuvation Bio Inc | 2021-06-30 | Added / first present |
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| Organon & Co | Organon & Co | 2021-06-30 | Added / first present |
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| NGM Biopharmaceuticals Inc | NGM Biopharmaceuticals Inc | 2021-03-31 | Added / first present |
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| Atea Pharmaceuticals Inc | Atea Pharmaceuticals Inc | 2021-03-31 | Added / first present |
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| Viatris Inc | Viatris Inc | 2020-12-31 | Added / first present |
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| Collegium Pharmaceutical Inc | Collegium Pharmaceutical Inc | 2020-09-30 | Added / first present |
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| ChemoCentryx Inc | ChemoCentryx Inc | 2020-09-30 | Added / first present |
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| Provention Bio Inc | Provention Bio Inc | 2020-09-30 | Added / first present |
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| Relmada Therapeutics Inc | Relmada Therapeutics Inc | 2020-06-30 | Added / first present |
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| Phathom Pharmaceuticals Inc | Phathom Pharmaceuticals Inc | 2020-06-30 | Added / first present |
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| Arvinas Holding Co LLC | Arvinas Holding Co LLC | 2019-12-31 | Added / first present |
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Removals
| Ticker | Issuer | Observed date | Change |
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| Ventyx Biosciences Inc | Ventyx Biosciences Inc | 2026-03-31 | Removed / first absent |
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| INDIVIOR PLC | INDIVIOR PLC | 2026-03-31 | Removed / first absent |
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| 1XAVH26 | XAV HEALTH CARE MAR26 | 2026-03-31 | Removed / first absent |
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| AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2026-03-31 | Removed / first absent |
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| 1XAVZ25 | XAV HEALTH CARE DEC25 | 2025-12-31 | Removed / first absent |
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| 1XAVU25 | XAV HEALTH CARE SEP25 | 2025-09-30 | Removed / first absent |
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| 1XAVM25 | XAV HEALTH CARE JUN25 | 2025-06-30 | Removed / first absent |
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| OMEROS CORPORATION | OMEROS CORPORATION | 2025-06-30 | Removed / first absent |
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| 1XAVH25 | XAV HEALTH CARE MAR25 | 2025-03-31 | Removed / first absent |
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| PHATHOM PHARMACEUTICALS, INC. | PHATHOM PHARMACEUTICALS, INC. | 2025-03-31 | Removed / first absent |
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| Neumora Therapeutics Inc | Neumora Therapeutics Inc | 2025-03-31 | Removed / first absent |
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| 1XAVZ24 | XAV HEALTH CARE DEC24 | 2024-12-31 | Removed / first absent |
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| Mind Medicine (MindMed) Inc | Mind Medicine (MindMed) Inc | 2026-03-31 | Removed / first absent |
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| 1XAVU24 | XAV HEALTH CARE SEP24 | 2024-09-30 | Removed / first absent |
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| 1XAVM24 | XAV HEALTH CARE JUN24 | 2024-06-30 | Removed / first absent |
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| CASSAVA SCIENCES INC | CASSAVA SCIENCES INC | 2024-03-31 | Removed / first absent |
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| CymaBay Therapeutics Inc | CymaBay Therapeutics Inc | 2024-03-31 | Removed / first absent |
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| IXCH4 | XAV HEALTH CARE MAR24 | 2024-03-31 | Removed / first absent |
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| IXCZ3 | XAV HEALTH CARE DEC23 | 2023-12-31 | Removed / first absent |
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| IXCU3 | XAV HEALTH CARE SEP23 | 2023-09-30 | Removed / first absent |
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| IXCM3 | XAV HEALTH CARE JUN23 | 2023-06-30 | Removed / first absent |
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| Aclaris Therapeutics Inc | Aclaris Therapeutics Inc | 2023-12-31 | Removed / first absent |
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| Dice Therapeutics Inc | Dice Therapeutics Inc | 2023-09-30 | Removed / first absent |
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| Ventyx Biosciences Inc | Ventyx Biosciences Inc | 2023-12-31 | Removed / first absent |
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| IXCH3 | XAV HEALTH CARE MAR23 | 2023-03-31 | Removed / first absent |
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| Pliant Therapeutics Inc | Pliant Therapeutics Inc | 2025-03-31 | Removed / first absent |
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| CinCor Pharma Inc | CinCor Pharma Inc | 2022-12-31 | Removed / first absent |
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| Amylyx Pharmaceuticals Inc | Amylyx Pharmaceuticals Inc | 2024-06-30 | Removed / first absent |
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| IXCZ2 | XAV HEALTH CARE DEC22 | 2022-12-31 | Removed / first absent |
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| Cassava Sciences Inc | Cassava Sciences Inc | 2024-12-31 | Removed / first absent |
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| Antares Pharma Inc | Antares Pharma Inc | 2022-06-30 | Removed / first absent |
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| Nuvation Bio Inc | Nuvation Bio Inc | 2023-06-30 | Removed / first absent |
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| NGM Biopharmaceuticals Inc | NGM Biopharmaceuticals Inc | 2022-12-31 | Removed / first absent |
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| Atea Pharmaceuticals Inc | Atea Pharmaceuticals Inc | 2023-12-31 | Removed / first absent |
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| ChemoCentryx Inc | ChemoCentryx Inc | 2022-12-31 | Removed / first absent |
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| Provention Bio Inc | Provention Bio Inc | 2021-12-31 | Removed / first absent |
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| Relmada Therapeutics Inc | Relmada Therapeutics Inc | 2021-12-31 | Removed / first absent |
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| Phathom Pharmaceuticals Inc | Phathom Pharmaceuticals Inc | 2022-06-30 | Removed / first absent |
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| Chicago Mercantile Exchange | Chicago Mercantile Exchange | 2022-09-30 | Removed / first absent |
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| BlackRock Funds III | BlackRock Funds III | 2023-03-31 | Removed / first absent |
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| Dermira Inc | Dermira Inc | 2020-03-31 | Removed / first absent |
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| Aerie Pharmaceuticals Inc | Aerie Pharmaceuticals Inc | 2022-12-31 | Removed / first absent |
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| Reata Pharmaceuticals Inc | Reata Pharmaceuticals Inc | 2023-09-30 | Removed / first absent |
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| Tricida Inc | Tricida Inc | 2020-12-31 | Removed / first absent |
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| MyoKardia Inc | MyoKardia Inc | 2020-12-31 | Removed / first absent |
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| Amicus Therapeutics Inc | Amicus Therapeutics Inc | 2023-09-30 | Removed / first absent |
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| Zogenix Inc | Zogenix Inc | 2022-03-31 | Removed / first absent |
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| Ironwood Pharmaceuticals Inc | Ironwood Pharmaceuticals Inc | 2023-09-30 | Removed / first absent |
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| Madrigal Pharmaceuticals Inc | Madrigal Pharmaceuticals Inc | 2023-09-30 | Removed / first absent |
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| Spectrum Pharmaceuticals Inc | Spectrum Pharmaceuticals Inc | 2021-12-31 | Removed / first absent |
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| TherapeuticsMD Inc | TherapeuticsMD Inc | 2021-12-31 | Removed / first absent |
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| Omeros Corp | Omeros Corp | 2022-06-30 | Removed / first absent |
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| Cara Therapeutics Inc | Cara Therapeutics Inc | 2023-06-30 | Removed / first absent |
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| Revance Therapeutics Inc | Revance Therapeutics Inc | 2025-03-31 | Removed / first absent |
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| Catalyst Pharmaceuticals Inc | Catalyst Pharmaceuticals Inc | 2023-09-30 | Removed / first absent |
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| Intersect ENT Inc | Intersect ENT Inc | 2020-12-31 | Removed / first absent |
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| Akorn Inc | Akorn Inc | 2020-06-30 | Removed / first absent |
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| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2025-06-30 | Removed / first absent |
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| AMAG Pharmaceuticals Inc | AMAG Pharmaceuticals Inc | 2020-12-31 | Removed / first absent |
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| Amneal Pharmaceuticals Inc | Amneal Pharmaceuticals Inc | 2022-09-30 | Removed / first absent |
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| Cymabay Therapeutics Inc | Cymabay Therapeutics Inc | 2019-12-31 | Removed / first absent |
|---|
| Phibro Animal Health Corp | Phibro Animal Health Corp | 2023-12-31 | Removed / first absent |
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| Catalent Inc | Catalent Inc | 2024-12-31 | Removed / first absent |
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| Vanda Pharmaceuticals Inc | Vanda Pharmaceuticals Inc | 2023-09-30 | Removed / first absent |
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