IBRN additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| ARROWHEAD PHARMACEUTICALS, INC. | ARROWHEAD PHARMACEUTICALS, INC. | 2026-04-30 | Added / first present |
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| OVID THERAPEUTICS INC. | OVID THERAPEUTICS INC. | 2026-04-30 | Added / first present |
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| Relmada Therapeutics Inc | Relmada Therapeutics Inc | 2026-04-30 | Added / first present |
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| AC Immune SA | AC Immune SA | 2026-04-30 | Added / first present |
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| Design Therapeutics Inc | Design Therapeutics Inc | 2026-04-30 | Added / first present |
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| Gain Therapeutics Inc | Gain Therapeutics Inc | 2026-04-30 | Added / first present |
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| Acumen Pharmaceuticals Inc | Acumen Pharmaceuticals Inc | 2026-04-30 | Added / first present |
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| Brainsway Ltd | Brainsway Ltd | 2026-04-30 | Added / first present |
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| PepGen Inc | PepGen Inc | 2026-04-30 | Added / first present |
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| Inhibikase Therapeutics Inc | Inhibikase Therapeutics Inc | 2026-04-30 | Added / first present |
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| Neumora Therapeutics Inc | Neumora Therapeutics Inc | 2026-04-30 | Added / first present |
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| Alto Neuroscience Inc | Alto Neuroscience Inc | 2026-04-30 | Added / first present |
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| LB Pharmaceuticals Inc | LB Pharmaceuticals Inc | 2026-04-30 | Added / first present |
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| MapLight Therapeutics Inc | MapLight Therapeutics Inc | 2026-04-30 | Added / first present |
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| Newron Pharmaceuticals SpA | Newron Pharmaceuticals SpA | 2026-04-30 | Added / first present |
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| Santhera Pharmaceuticals Holding AG | Santhera Pharmaceuticals Holding AG | 2026-04-30 | Added / first present |
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| Myung In Pharm Co Ltd | Myung In Pharm Co Ltd | 2026-04-30 | Added / first present |
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| BrainAurora Medical Technology Ltd | BrainAurora Medical Technology Ltd | 2026-04-30 | Added / first present |
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| BlackRock Funds III: BlackRock Cash Funds: Treasury; SL Agency Shares | BlackRock Funds III: BlackRock Cash Funds: Treasury; SL Agency Shares | 2026-01-31 | Added / first present |
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| HONG KONG DOLLAR | HONG KONG DOLLAR | 2026-01-31 | Added / first present |
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| ALKERMES PUBLIC LIMITED COMPANY | ALKERMES PUBLIC LIMITED COMPANY | 2026-01-31 | Added / first present |
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| Prothena Corporation PLC | Prothena Corporation PLC | 2026-01-31 | Added / first present |
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| Biohaven Ltd | Biohaven Ltd | 2026-01-31 | Added / first present |
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| AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2026-01-31 | Added / first present |
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| SK Biopharmaceuticals Co Ltd | SK Biopharmaceuticals Co Ltd | 2026-01-31 | Added / first present |
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| PEIJIA MEDICAL LIMITED | PEIJIA MEDICAL LIMITED | 2026-01-31 | Added / first present |
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| Oncolys Biopharma Inc | Oncolys Biopharma Inc | 2026-01-31 | Added / first present |
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| Axsome Therapeutics Inc | Axsome Therapeutics Inc | 2025-10-31 | Added / first present |
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| Neuronetics Inc | Neuronetics Inc | 2025-10-31 | Added / first present |
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| Centessa Pharmaceuticals PLC | Centessa Pharmaceuticals PLC | 2025-10-31 | Added / first present |
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| Cognition Therapeutics Inc | Cognition Therapeutics Inc | 2025-10-31 | Added / first present |
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| Benitec Biopharma Inc | Benitec Biopharma Inc | 2025-10-31 | Added / first present |
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| Tonix Pharmaceuticals Holding Corp | Tonix Pharmaceuticals Holding Corp | 2025-10-31 | Added / first present |
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| Denali Therapeutics Inc | Denali Therapeutics Inc | 2025-04-30 | Added / first present |
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| REGENXBIO Inc | REGENXBIO Inc | 2025-04-30 | Added / first present |
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| Fulcrum Therapeutics Inc | Fulcrum Therapeutics Inc | 2025-04-30 | Added / first present |
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| Design Therapeutics Inc | Design Therapeutics Inc | 2025-04-30 | Added / first present |
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| NeuroPace Inc | NeuroPace Inc | 2025-04-30 | Added / first present |
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| Ceribell Inc | Ceribell Inc | 2025-04-30 | Added / first present |
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| Bright Minds Biosciences Inc | Bright Minds Biosciences Inc | 2025-04-30 | Added / first present |
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| Sangamo Therapeutics Inc | Sangamo Therapeutics Inc | 2024-10-31 | Added / first present |
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| ClearPoint Neuro Inc | ClearPoint Neuro Inc | 2024-10-31 | Added / first present |
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| Taysha Gene Therapies Inc | Taysha Gene Therapies Inc | 2024-10-31 | Added / first present |
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| Zevra Therapeutics Inc | Zevra Therapeutics Inc | 2024-10-31 | Added / first present |
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| Climb Bio Inc | Climb Bio Inc | 2024-10-31 | Added / first present |
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| Praxis Precision Medicines Inc | Praxis Precision Medicines Inc | 2024-10-31 | Added / first present |
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| Neurogene Inc | Neurogene Inc | 2024-10-31 | Added / first present |
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| Contineum Therapeutics Inc | Contineum Therapeutics Inc | 2024-10-31 | Added / first present |
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| Rapport Therapeutics Inc | Rapport Therapeutics Inc | 2024-10-31 | Added / first present |
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| Capricor Therapeutics Inc | Capricor Therapeutics Inc | 2024-04-30 | Added / first present |
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| Larimar Therapeutics Inc | Larimar Therapeutics Inc | 2024-04-30 | Added / first present |
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| Athira Pharma Inc | Athira Pharma Inc | 2024-04-30 | Added / first present |
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| Longboard Pharmaceuticals Inc | Longboard Pharmaceuticals Inc | 2024-04-30 | Added / first present |
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| NeuroPace Inc | NeuroPace Inc | 2024-04-30 | Added / first present |
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| Brainsway Ltd | Brainsway Ltd | 2024-04-30 | Added / first present |
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| Abeona Therapeutics Inc | Abeona Therapeutics Inc | 2024-04-30 | Added / first present |
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| PepGen Inc | PepGen Inc | 2024-04-30 | Added / first present |
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| Solid Biosciences Inc | Solid Biosciences Inc | 2024-04-30 | Added / first present |
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| Vistagen Therapeutics Inc | Vistagen Therapeutics Inc | 2024-04-30 | Added / first present |
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| Dianthus Therapeutics Inc | Dianthus Therapeutics Inc | 2024-04-30 | Added / first present |
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| Neumora Therapeutics Inc | Neumora Therapeutics Inc | 2024-04-30 | Added / first present |
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| Kyverna Therapeutics Inc | Kyverna Therapeutics Inc | 2024-04-30 | Added / first present |
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| Alto Neuroscience Inc | Alto Neuroscience Inc | 2024-04-30 | Added / first present |
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Removals
| Ticker | Issuer | Observed date | Change |
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| AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | AVADEL PHARMACEUTICALS PUBLIC LIMITED COMPANY | 2026-04-30 | Removed / first absent |
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| Neuronetics Inc | Neuronetics Inc | 2026-01-31 | Removed / first absent |
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| Fulcrum Therapeutics Inc | Fulcrum Therapeutics Inc | 2026-04-30 | Removed / first absent |
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| Design Therapeutics Inc | Design Therapeutics Inc | 2025-07-31 | Removed / first absent |
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| Zevra Therapeutics Inc | Zevra Therapeutics Inc | 2025-10-31 | Removed / first absent |
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| Climb Bio Inc | Climb Bio Inc | 2025-07-31 | Removed / first absent |
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| Contineum Therapeutics Inc | Contineum Therapeutics Inc | 2025-07-31 | Removed / first absent |
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| Athira Pharma Inc | Athira Pharma Inc | 2024-10-31 | Removed / first absent |
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| Longboard Pharmaceuticals Inc | Longboard Pharmaceuticals Inc | 2025-01-31 | Removed / first absent |
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| NeuroPace Inc | NeuroPace Inc | 2024-10-31 | Removed / first absent |
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| Brainsway Ltd | Brainsway Ltd | 2024-07-31 | Removed / first absent |
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| Abeona Therapeutics Inc | Abeona Therapeutics Inc | 2025-10-31 | Removed / first absent |
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| PepGen Inc | PepGen Inc | 2025-01-31 | Removed / first absent |
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| Vistagen Therapeutics Inc | Vistagen Therapeutics Inc | 2024-10-31 | Removed / first absent |
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| Neumora Therapeutics Inc | Neumora Therapeutics Inc | 2024-10-31 | Removed / first absent |
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| Kyverna Therapeutics Inc | Kyverna Therapeutics Inc | 2024-10-31 | Removed / first absent |
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| Alto Neuroscience Inc | Alto Neuroscience Inc | 2025-07-31 | Removed / first absent |
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| Cellivery Therapeutics Inc | Cellivery Therapeutics Inc | 2026-01-31 | Removed / first absent |
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| Nevro Corp | Nevro Corp | 2025-04-30 | Removed / first absent |
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| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2025-04-30 | Removed / first absent |
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| Axonics Inc | Axonics Inc | 2025-01-31 | Removed / first absent |
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| Ovid therapeutics Inc | Ovid therapeutics Inc | 2024-01-31 | Removed / first absent |
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| Avadel Pharmaceuticals PLC | Avadel Pharmaceuticals PLC | 2024-04-30 | Removed / first absent |
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| Karuna Therapeutics Inc | Karuna Therapeutics Inc | 2024-04-30 | Removed / first absent |
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| Seelos Therapeutics Inc | Seelos Therapeutics Inc | 2024-01-31 | Removed / first absent |
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| Bioxcel Therapeutics Inc | Bioxcel Therapeutics Inc | 2024-04-30 | Removed / first absent |
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| ClearPoint Neuro Inc | ClearPoint Neuro Inc | 2024-01-31 | Removed / first absent |
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| Larimar Therapeutics Inc | Larimar Therapeutics Inc | 2024-01-31 | Removed / first absent |
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| Harmony Biosciences Holdings Inc | Harmony Biosciences Holdings Inc | 2024-04-30 | Removed / first absent |
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| Cerevel Therapeutics Holdings Inc | Cerevel Therapeutics Holdings Inc | 2024-10-31 | Removed / first absent |
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| Design Therapeutics Inc | Design Therapeutics Inc | 2024-04-30 | Removed / first absent |
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| Acumen Pharmaceuticals Inc | Acumen Pharmaceuticals Inc | 2025-01-31 | Removed / first absent |
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| CVRx Inc | CVRx Inc | 2024-10-31 | Removed / first absent |
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| Amylyx Pharmaceuticals Inc | Amylyx Pharmaceuticals Inc | 2025-10-31 | Removed / first absent |
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