| Insmed Inc | Insmed Inc | 3.036459189905% | 17,029,299.84 | 104,142 NS |
|---|
| Vaxcyte Inc | Vaxcyte Inc | 2.973017667339% | 16,673,502.3 | 286,930 NS |
|---|
| uniQure NV | uniQure NV | 2.836387380031% | 15,907,242 | 972,920 NS |
|---|
| Argenx SE | Argenx SE | 2.557702562309% | 14,344,300.75 | 19,643 NS |
|---|
| Dyne Therapeutics Inc | Dyne Therapeutics Inc | 2.469667644017% | 13,850,576.67 | 763,959 NS |
|---|
| Denali Therapeutics Inc | Denali Therapeutics Inc | 2.275663362331% | 12,762,547.2 | 664,716 NS |
|---|
| Axsome Therapeutics Inc | Axsome Therapeutics Inc | 2.222527906124% | 12,464,548.92 | 73,746 NS |
|---|
| Xenon Pharmaceuticals Inc | Xenon Pharmaceuticals Inc | 2.101343182999% | 11,784,911.6 | 202,664 NS |
|---|
| Fulcrum Therapeutics Inc | Fulcrum Therapeutics Inc | 2.076741934591% | 11,646,941.02 | 1,518,506 NS |
|---|
| Tectonic Therapeutic Inc | Tectonic Therapeutic Inc | 2.044126457998% | 11,464,024.44 | 370,884 NS |
|---|
| NEUROVANCE MILESTONE INTEREST | NEUROVANCE MILESTONE INTEREST | 2.04301683884% | 11,457,801.39 | 34,054.99 NS |
|---|
| Crinetics Pharmaceuticals Inc | Crinetics Pharmaceuticals Inc | 2.021547774262% | 11,337,396.96 | 312,153 NS |
|---|
| Edgewise Therapeutics Inc | Edgewise Therapeutics Inc | 1.983121887731% | 11,121,894 | 353,076 NS |
|---|
| Immunovant Inc | Immunovant Inc | 1.955469237901% | 10,966,810.32 | 441,498 NS |
|---|
| Alnylam Pharmaceuticals Inc | Alnylam Pharmaceuticals Inc | 1.78264563268% | 9,997,567.92 | 30,216 NS |
|---|
| Cytokinetics Inc | Cytokinetics Inc | 1.763135148757% | 9,888,147.75 | 150,025 NS |
|---|
| VeraDermics Inc | VeraDermics Inc | 1.752337658613% | 9,827,592.45 | 155,623 NS |
|---|
| Regeneron Pharmaceuticals Inc | Regeneron Pharmaceuticals Inc | 1.708045660531% | 9,579,190.72 | 12,398 NS |
|---|
| BioCryst Pharmaceuticals Inc | BioCryst Pharmaceuticals Inc | 1.690730377233% | 9,482,081.84 | 996,017 NS |
|---|
| Personalis Inc | Personalis Inc | 1.625122056712% | 9,114,132.3 | 1,430,790 NS |
|---|
| Praxis Precision Medicines Inc | Praxis Precision Medicines Inc | 1.622590451432% | 9,099,934.36 | 28,244 NS |
|---|
| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 1.615286338141% | 9,058,970.88 | 416,313 NS |
|---|
| Arrowhead Pharmaceuticals Inc | Arrowhead Pharmaceuticals Inc | 1.601689399244% | 8,982,715.5 | 143,265 NS |
|---|
| EyePoint Inc | EyePoint Inc | 1.415819243561% | 7,940,304.45 | 616,005 NS |
|---|
| Shattuck Labs Inc | Shattuck Labs Inc | 1.32918469512% | 7,454,434.03 | 1,159,321 NS |
|---|
| Ideaya Biosciences Inc | Ideaya Biosciences Inc | 1.251286327621% | 7,017,558.52 | 210,611 NS |
|---|
| VERADERMICS, INC. | VERADERMICS, INC. | 1.230790228788% | 6,902,610.75 | 109,305 NS |
|---|
| Oculis Holding AG | Oculis Holding AG | 1.203034076553% | 6,746,946.6 | 253,740 NS |
|---|
| Sionna Therapeutics Inc | Sionna Therapeutics Inc | 1.201289866607% | 6,737,164.59 | 168,051 NS |
|---|
| Equillium Inc | Equillium Inc | 1.195674844715% | 6,705,674 | 3,352,837 NS |
|---|
| Syndax Pharmaceuticals Inc | Syndax Pharmaceuticals Inc | 1.195304292309% | 6,703,595.84 | 286,969 NS |
|---|
| Amgen Inc | Amgen Inc | 1.168739586525% | 6,554,613.65 | 18,629 NS |
|---|
| Biohaven Ltd | Biohaven Ltd | 1.16372383262% | 6,526,483.92 | 771,452 NS |
|---|
| Abivax SA | Abivax SA | 1.160381536076% | 6,507,739.4 | 58,444 NS |
|---|
| Apogee Therapeutics Inc | Apogee Therapeutics Inc | 1.153243436382% | 6,467,706.97 | 76,841 NS |
|---|
| Disc Medicine Inc | Disc Medicine Inc | 1.132564832251% | 6,351,735.66 | 99,339 NS |
|---|
| Travere Therapeutics Inc | Travere Therapeutics Inc | 1.080234944522% | 6,058,255.23 | 203,913 NS |
|---|
| Precision BioSciences Inc | Precision BioSciences Inc | 1.065003840201% | 5,972,835 | 1,085,970 NS |
|---|
| Structure Therapeutics Inc | Structure Therapeutics Inc | 1.028694568642% | 5,769,202.6 | 119,693 NS |
|---|
| Nuvalent Inc | Nuvalent Inc | 1.01739835122% | 5,705,850.3 | 55,694 NS |
|---|
| Adaptive Biotechnologies Corp | Adaptive Biotechnologies Corp | 0.977514330202% | 5,482,169.72 | 394,969 NS |
|---|
| ARS Pharmaceuticals Inc | ARS Pharmaceuticals Inc | 0.914219549713% | 5,127,195.15 | 638,505 NS |
|---|
| Corbus Pharmaceuticals Holdings Inc | Corbus Pharmaceuticals Holdings Inc | 0.910354950016% | 5,105,521.41 | 543,719 NS |
|---|
| Newamsterdam Pharma Co NV | Newamsterdam Pharma Co NV | 0.898319250384% | 5,038,021.89 | 157,389 NS |
|---|
| Codexis Inc | Codexis Inc | 0.898162601519% | 5,037,143.36 | 3,090,272 NS |
|---|
| IMMUNIC | IMMUNIC | 0.879684030158% | 4,933,510.44 | 4,444,604 NS |
|---|
| Taysha Gene Therapies Inc | Taysha Gene Therapies Inc | 0.813824422056% | 4,564,151.61 | 1,021,063 NS |
|---|
| Summit Therapeutics Inc | Summit Therapeutics Inc | 0.805391910215% | 4,516,859.76 | 238,231 NS |
|---|
| CURASEN THERAPEUTICS, INC. | CURASEN THERAPEUTICS, INC. | 0.773692863272% | 4,339,082.77 | 9,049,182 NS |
|---|
| Vertex Pharmaceuticals Inc | Vertex Pharmaceuticals Inc | 0.729572928775% | 4,091,646.02 | 9,163 NS |
|---|
| Jade Biosciences Inc | Jade Biosciences Inc | 0.695338114845% | 3,899,647.75 | 277,555 NS |
|---|
| Vericel Corp | Vericel Corp | 0.680555952444% | 3,816,745.31 | 118,643 NS |
|---|
| GRAIL Inc | GRAIL Inc | 0.678248243082% | 3,803,803.04 | 73,603 NS |
|---|
| Cogent Biosciences Inc | Cogent Biosciences Inc | 0.671709464867% | 3,767,131.77 | 97,873 NS |
|---|
| Guardant Health Inc | Guardant Health Inc | 0.662419133193% | 3,715,029.03 | 40,219 NS |
|---|
| Oruka Therapeutics Inc | Oruka Therapeutics Inc | 0.661897577151% | 3,712,104 | 75,680 NS |
|---|
| Allogene Therapeutics Inc | Allogene Therapeutics Inc | 0.63616959024% | 3,567,814.36 | 1,462,219 NS |
|---|
| Revolution Medicines Inc | Revolution Medicines Inc | 0.636012882534% | 3,566,935.5 | 36,678 NS |
|---|
| LENZ Therapeutics Inc | LENZ Therapeutics Inc | 0.606557437903% | 3,401,741.25 | 371,775 NS |
|---|
| Arcutis Biotherapeutics Inc | Arcutis Biotherapeutics Inc | 0.606241103589% | 3,399,967.16 | 144,311 NS |
|---|
| Jazz Pharmaceuticals PLC | Jazz Pharmaceuticals PLC | 0.602449285623% | 3,378,701.6 | 17,872 NS |
|---|
| Immunic Inc | Immunic Inc | 0.599488510988% | 3,362,096.76 | 3,028,916 NS |
|---|
| Palvella Therapeutics Inc | Palvella Therapeutics Inc | 0.585034966534% | 3,281,037.3 | 26,322 NS |
|---|
| Soleno Therapeutics Inc | Soleno Therapeutics Inc | 0.581781934505% | 3,262,793.4 | 97,455 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.552755151052% | 3,100,003.2 | 1,291,668 NS |
|---|
| Arcus Biosciences Inc | Arcus Biosciences Inc | 0.54081308448% | 3,033,028.8 | 140,418 NS |
|---|
| Krystal Biotech Inc | Krystal Biotech Inc | 0.526471563766% | 2,952,597.6 | 11,430 NS |
|---|
| Tempus AI Inc | Tempus AI Inc | 0.506329457882% | 2,839,635.12 | 62,796 NS |
|---|
| Rhythm Pharmaceuticals Inc | Rhythm Pharmaceuticals Inc | 0.502549627557% | 2,818,436.79 | 32,407 NS |
|---|
| Ascendis Pharma A/S | Ascendis Pharma A/S | 0.470814797779% | 2,640,459.12 | 11,544 NS |
|---|
| Ionis Pharmaceuticals Inc | Ionis Pharmaceuticals Inc | 0.467856802965% | 2,623,869.87 | 34,943 NS |
|---|
| IMMUNIC INC. | IMMUNIC INC. | 0.457560766427% | 2,566,126.86 | 2,311,826 NS |
|---|
| Avalo Therapeutics Inc | Avalo Therapeutics Inc | 0.457033083724% | 2,563,167.47 | 171,679 NS |
|---|
| Rocket Pharmaceuticals Inc | Rocket Pharmaceuticals Inc | 0.424383423718% | 2,380,059.18 | 664,821 NS |
|---|
| Immatics NV | Immatics NV | 0.418877763429% | 2,349,181.92 | 238,738 NS |
|---|
| Caribou Biosciences Inc | Caribou Biosciences Inc | 0.410790782042% | 2,303,827.9 | 1,212,541 NS |
|---|
| THIRD ARC BIO, INC | THIRD ARC BIO, INC | 0.394060377281% | 2,209,999.18 | 1,050,280 NS |
|---|
| IMMUNIC | IMMUNIC | 0.384524947094% | 2,156,521.86 | 4,444,604 NS |
|---|
| Neurocrine Biosciences Inc | Neurocrine Biosciences Inc | 0.381646686236% | 2,140,379.78 | 16,247 NS |
|---|
| GeneDx Holdings Corp | GeneDx Holdings Corp | 0.316400790846% | 1,774,462.82 | 27,631 NS |
|---|
| QUELL THERAPEUTICS | QUELL THERAPEUTICS | 0.31382201242% | 1,760,000.32 | 846,561 NS |
|---|
| IMMUNIC INC. | IMMUNIC INC. | 0.299351917425% | 1,678,848.04 | 2,311,826 NS |
|---|
| Maze Therapeutics Inc | Maze Therapeutics Inc | 0.290842235695% | 1,631,123.4 | 54,644 NS |
|---|
| ARBOR BIOTECHNOLOGIES | ARBOR BIOTECHNOLOGIES | 0.285292390701% | 1,599,998.34 | 389,294 NS |
|---|
| GLYCOMINE, INC. | GLYCOMINE, INC. | 0.284055764587% | 1,593,063 | 2,655,105 NS |
|---|
| QLARIS BIO, INC. | QLARIS BIO, INC. | 0.276377249222% | 1,549,999.77 | 1,974,522 NS |
|---|
| Ocular Therapeutix Inc | Ocular Therapeutix Inc | 0.274962441778% | 1,542,065.14 | 182,062 NS |
|---|
| Immunocore Holdings PLC | Immunocore Holdings PLC | 0.268482020183% | 1,505,721.15 | 49,941 NS |
|---|
| AgomAb Therapeutics NV | AgomAb Therapeutics NV | 0.265205519264% | 1,487,345.63 | 141,787 NS |
|---|
| RECODE THERAPEUTICS | RECODE THERAPEUTICS | 0.25676353214% | 1,440,000.64 | 155,959 NS |
|---|
| Lexeo Therapeutics Inc | Lexeo Therapeutics Inc | 0.251679673522% | 1,411,488.96 | 245,904 NS |
|---|
| ENDEAVOR BIOMEDICINES, INC. | ENDEAVOR BIOMEDICINES, INC. | 0.24963072106% | 1,399,997.87 | 296,855 NS |
|---|
| EVOMMUNE | EVOMMUNE | 0.239009645215% | 1,340,431.95 | 58,305 NS |
|---|
| ABCURO, INC. | ABCURO, INC. | 0.227341504199% | 1,274,993.8 | 232,252 NS |
|---|
| SEISMIC THERAPEUTICS, INC. | SEISMIC THERAPEUTICS, INC. | 0.227340999587% | 1,274,990.97 | 282,340 NS |
|---|
| ENGRAIL THERAPEUTICS INC. SERI | ENGRAIL THERAPEUTICS INC. SERI | 0.225827256205% | 1,266,501.48 | 2,124,646 NS |
|---|
| Twist Bioscience Corp | Twist Bioscience Corp | 0.210279225587% | 1,179,303.84 | 24,817 NS |
|---|
| Palisade Bio Inc | Palisade Bio Inc | 0.206850570946% | 1,160,075 | 662,900 NS |
|---|
| AMOLYT MILESTONE | AMOLYT MILESTONE | 0.195068145246% | 1,093,995.91 | 6,849.46 NS |
|---|
| WaVe Life Sciences Ltd | WaVe Life Sciences Ltd | 0.193909872986% | 1,087,500 | 150,000 NS |
|---|
| PRECISION BIOSCIENCES | PRECISION BIOSCIENCES | 0.184128315448% | 1,032,642.33 | 336,267 NS |
|---|
| CRYSTALYS THERAPEUTICS SER A | CRYSTALYS THERAPEUTICS SER A | 0.182302017881% | 1,022,399.95 | 1,020,512 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.164186167642% | 920,801.27 | 284,119 NS |
|---|
| SpyGlass Pharma Inc | SpyGlass Pharma Inc | 0.163800626672% | 918,639.05 | 35,455 NS |
|---|
| State Street Global Advisors | State Street Global Advisors | 0.151847456865% | 851,602.38 | 851,602.38 NS |
|---|
| TScan Therapeutics Inc | TScan Therapeutics Inc | 0.150697094344% | 845,150.83 | 836,783 NS |
|---|
| NUVIG THERAPEUTICS, INC | NUVIG THERAPEUTICS, INC | 0.138188607672% | 774,999.79 | 739,010 NS |
|---|
| INCENDIA THERAPEUTICS, INC. | INCENDIA THERAPEUTICS, INC. | 0.131673273384% | 738,460 | 738,460 PA |
|---|
| ATALANTA THERAPEUTICS | ATALANTA THERAPEUTICS | 0.124815586089% | 700,000.2 | 777,778 NS |
|---|
| INVETX MILESTONE INTEREST | INVETX MILESTONE INTEREST | 0.124329083603% | 697,271.76 | 13,998.63 NS |
|---|
| CURASEN THERAPEUTICS, INC. | CURASEN THERAPEUTICS, INC. | 0.11797283565% | 661,624.17 | 1,379,821 NS |
|---|
| ARBOR BIOTECHNOLOGIES | ARBOR BIOTECHNOLOGIES | 0.114117017618% | 639,999.68 | 38,624 NS |
|---|
| Iovance Biotherapeutics Inc | Iovance Biotherapeutics Inc | 0.097008428871% | 544,050 | 155,000 NS |
|---|
| HIBERCELL, INC. SERIES B | HIBERCELL, INC. SERIES B | 0.095997376553% | 538,379.74 | 1,305,163 NS |
|---|
| ENDEAVOR BIOMEDICINES INC. | ENDEAVOR BIOMEDICINES INC. | 0.063771108725% | 357,645.95 | 54,815 NS |
|---|
| HIBERCELL,INC. SERIES C | HIBERCELL,INC. SERIES C | 0.059488993879% | 333,630.67 | 719,652 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.057748626469% | 323,870.21 | 323,870.21 PA |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 0.057058537338% | 320,000 | 320,000 PA |
|---|
| ABCURO INC. | ABCURO INC. | 0.055348082866% | 310,407.3 | 51,403 NS |
|---|
| BIOTHERYX, INC. SERIES E | BIOTHERYX, INC. SERIES E | 0.054917501312% | 307,992.48 | 609,524 NS |
|---|
| Incendia Therapeutics, Inc. | Incendia Therapeutics, Inc. | 0.053849379758% | 302,002.16 | 832,650 NS |
|---|
| INCENDIA THERAPEUTICS, INC. | INCENDIA THERAPEUTICS, INC. | 0.045929569187% | 257,585.68 | 257,585.68 PA |
|---|
| OCULIS HOLDINGS AG | OCULIS HOLDINGS AG | 0.042547599129% | 238,618.66 | 8,974 NS |
|---|
| Quoin Pharmaceuticals Ltd | Quoin Pharmaceuticals Ltd | 0.040718398708% | 228,360 | 34,600 NS |
|---|
| AVICEDA THERAPEUTICS | AVICEDA THERAPEUTICS | 0.03995716293% | 224,090.78 | 38,906 NS |
|---|
| HIBERCELL, INC. | HIBERCELL, INC. | 0.036836456781% | 206,589 | 206,589 PA |
|---|
| QLARIS BIO, INC. | QLARIS BIO, INC. | 0.034159876457% | 191,578 | 191,578 PA |
|---|
| RECODE THERAPEUTICS, INC. | RECODE THERAPEUTICS, INC. | 0.013540531183% | 75,939.03 | 75,939.03 PA |
|---|
| CONTRA CHINOOK THERAPE | CONTRA CHINOOK THERAPE | 0.00337004839% | 18,900.16 | 59,063 NS |
|---|
| CONTRA FUSION PHARMACE | CONTRA FUSION PHARMACE | 0.000801187452% | 4,493.28 | 3,256 NS |
|---|
| IO LIGHT HOLDINIGS, INC. | IO LIGHT HOLDINIGS, INC. | 0.000007517462% | 42.16 | 421,634 NS |
|---|
| PRIOTHERA LIMITED | PRIOTHERA LIMITED | 0.000003143568% | 17.63 | 152,534 NS |
|---|
| Willow Laboratories Inc. | Willow Laboratories Inc. | 0.000002318003% | 13 | 130,000 NS |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 4.60034e-7% | 2.58 | 2,582,362 NS |
|---|
| HIBERCELL, INC. SERIES C | HIBERCELL, INC. SERIES C | 1.28381e-7% | 0.72 | 719,652 NS |
|---|
| Afferent Milestone Interest | Afferent Milestone Interest | 1.783e-9% | 0.01 | 11,232.03 NS |
|---|
| ETHISMOS RESEARCH, INC. MILEST | ETHISMOS RESEARCH, INC. MILEST | 0% | 0 | 820 NS |
|---|
| AMPHIVENA MILESTONE INTEREST | AMPHIVENA MILESTONE INTEREST | 0% | 0 | 100 NS |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 0% | 0 | 4,000,000 NS |
|---|
| RECODE THERAPEUTICS, INC. | RECODE THERAPEUTICS, INC. | 0% | 0 | 75,939 NS |
|---|
| Options Clearing Corp. | Options Clearing Corp. | -0.0004992622% | -2,800 | -700 NC |
|---|
| Options Clearing Corp. | Options Clearing Corp. | -0.00066330549% | -3,720 | -124 NC |
|---|
| Options Clearing Corp. | Options Clearing Corp. | -0.01060932178% | -59,500 | -3,500 NC |
|---|