| Vaxcyte Inc | Vaxcyte Inc | 3.102636861986% | 35,276,547.15 | 607,065 NS |
|---|
| uniQure NV | uniQure NV | 3.011254075543% | 34,237,537.65 | 2,094,039 NS |
|---|
| Amgen Inc | Amgen Inc | 2.525119568382% | 28,710,256.3 | 81,598 NS |
|---|
| Insmed Inc | Insmed Inc | 2.361116905294% | 26,845,568.96 | 164,173 NS |
|---|
| Argenx SE | Argenx SE | 2.342737614991% | 26,636,599 | 36,476 NS |
|---|
| Tectonic Therapeutic Inc | Tectonic Therapeutic Inc | 2.095870585116% | 23,829,755.4 | 770,940 NS |
|---|
| Denali Therapeutics Inc | Denali Therapeutics Inc | 2.009067459233% | 22,842,816 | 1,189,730 NS |
|---|
| Xenon Pharmaceuticals Inc | Xenon Pharmaceuticals Inc | 1.99267720923% | 22,656,461.15 | 389,621 NS |
|---|
| VeraDermics Inc | VeraDermics Inc | 1.92002799977% | 21,830,449.8 | 345,692 NS |
|---|
| Praxis Precision Medicines Inc | Praxis Precision Medicines Inc | 1.807318276385% | 20,548,956.01 | 63,779 NS |
|---|
| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 1.801987479935% | 20,488,345.6 | 941,560 NS |
|---|
| BioCryst Pharmaceuticals Inc | BioCryst Pharmaceuticals Inc | 1.744870006839% | 19,838,927.92 | 2,083,921 NS |
|---|
| Abbott Laboratories | Abbott Laboratories | 1.701028951243% | 19,340,461.25 | 188,375 NS |
|---|
| Crinetics Pharmaceuticals Inc | Crinetics Pharmaceuticals Inc | 1.623533555517% | 18,459,349.44 | 508,242 NS |
|---|
| Immunovant Inc | Immunovant Inc | 1.571392924647% | 17,866,517.76 | 719,264 NS |
|---|
| Regeneron Pharmaceuticals Inc | Regeneron Pharmaceuticals Inc | 1.571053993477% | 17,862,664.16 | 23,119 NS |
|---|
| Cytokinetics Inc | Cytokinetics Inc | 1.554451692492% | 17,673,898.32 | 268,152 NS |
|---|
| NEUROVANCE MILESTONE INTEREST | NEUROVANCE MILESTONE INTEREST | 1.450159358496% | 16,488,109.07 | 49,006.12 NS |
|---|
| Danaher Corp | Danaher Corp | 1.425152518765% | 16,203,784.8 | 85,463 NS |
|---|
| Sionna Therapeutics Inc | Sionna Therapeutics Inc | 1.396728805865% | 15,880,611.16 | 396,124 NS |
|---|
| VERADERMICS, INC. | VERADERMICS, INC. | 1.387645289548% | 15,777,332.85 | 249,839 NS |
|---|
| Oculis Holding AG | Oculis Holding AG | 1.355325577093% | 15,409,862.24 | 579,536 NS |
|---|
| Edgewise Therapeutics Inc | Edgewise Therapeutics Inc | 1.310391186148% | 14,898,964.5 | 472,983 NS |
|---|
| Alnylam Pharmaceuticals Inc | Alnylam Pharmaceuticals Inc | 1.280340059209% | 14,557,287.39 | 43,997 NS |
|---|
| EyePoint Inc | EyePoint Inc | 1.272433240745% | 14,467,387.97 | 1,122,373 NS |
|---|
| Jazz Pharmaceuticals PLC | Jazz Pharmaceuticals PLC | 1.267515201352% | 14,411,470.55 | 76,231 NS |
|---|
| Intuitive Surgical Inc | Intuitive Surgical Inc | 1.226199831181% | 13,941,720.57 | 30,243 NS |
|---|
| Merck & Co Inc | Merck & Co Inc | 1.217430181522% | 13,842,010.88 | 115,072 NS |
|---|
| Arrowhead Pharmaceuticals Inc | Arrowhead Pharmaceuticals Inc | 1.217106344644% | 13,838,328.9 | 220,707 NS |
|---|
| Zoetis Inc | Zoetis Inc | 1.200506456179% | 13,649,590.49 | 115,469 NS |
|---|
| Personalis Inc | Personalis Inc | 1.152730949368% | 13,106,389.66 | 2,057,518 NS |
|---|
| Axsome Therapeutics Inc | Axsome Therapeutics Inc | 1.12892477964% | 12,835,716.84 | 75,942 NS |
|---|
| ARS Pharmaceuticals Inc | ARS Pharmaceuticals Inc | 1.093289827633% | 12,430,552.42 | 1,548,014 NS |
|---|
| Dyne Therapeutics Inc | Dyne Therapeutics Inc | 1.06265909286% | 12,082,285.25 | 666,425 NS |
|---|
| Ideaya Biosciences Inc | Ideaya Biosciences Inc | 0.981794522882% | 11,162,866.4 | 335,020 NS |
|---|
| Thermo Fisher Scientific Inc | Thermo Fisher Scientific Inc | 0.96599586327% | 10,983,237.85 | 22,345 NS |
|---|
| Newamsterdam Pharma Co NV | Newamsterdam Pharma Co NV | 0.962015093103% | 10,937,977.05 | 341,705 NS |
|---|
| Travere Therapeutics Inc | Travere Therapeutics Inc | 0.923017699556% | 10,494,582.14 | 353,234 NS |
|---|
| Elevance Health Inc | Elevance Health Inc | 0.896181341276% | 10,189,456.5 | 34,806 NS |
|---|
| CURASEN THERAPEUTICS, INC. | CURASEN THERAPEUTICS, INC. | 0.890471300056% | 10,124,534.13 | 21,114,774 NS |
|---|
| Insulet Corp | Insulet Corp | 0.879419437625% | 9,998,876 | 47,650 NS |
|---|
| Abivax SA | Abivax SA | 0.868432956825% | 9,873,961.25 | 88,675 NS |
|---|
| IMMUNIC | IMMUNIC | 0.863747119058% | 9,820,683.93 | 8,847,463 NS |
|---|
| Inspire Medical Systems Inc | Inspire Medical Systems Inc | 0.856655896379% | 9,740,057.72 | 188,834 NS |
|---|
| Vericel Corp | Vericel Corp | 0.837168765711% | 9,518,491.77 | 295,881 NS |
|---|
| Adaptive Biotechnologies Corp | Adaptive Biotechnologies Corp | 0.824823958614% | 9,378,133.04 | 675,658 NS |
|---|
| Medtronic PLC | Medtronic PLC | 0.8141770739% | 9,257,079.45 | 106,833 NS |
|---|
| Codexis Inc | Codexis Inc | 0.801404447996% | 9,111,856.48 | 5,590,096 NS |
|---|
| Vertex Pharmaceuticals Inc | Vertex Pharmaceuticals Inc | 0.78445907507% | 8,919,189.96 | 19,974 NS |
|---|
| Jade Biosciences Inc | Jade Biosciences Inc | 0.728741810051% | 8,285,692.45 | 589,729 NS |
|---|
| Disc Medicine Inc | Disc Medicine Inc | 0.7159568533% | 8,140,329.28 | 127,312 NS |
|---|
| AstraZeneca PLC | AstraZeneca PLC | 0.713313793521% | 8,110,278.06 | 41,123 NS |
|---|
| Summit Therapeutics Inc | Summit Therapeutics Inc | 0.712272762245% | 8,098,441.68 | 427,133 NS |
|---|
| Structure Therapeutics Inc | Structure Therapeutics Inc | 0.703974535272% | 8,004,092 | 166,060 NS |
|---|
| Charles River Laboratories International Inc | Charles River Laboratories International Inc | 0.682437814746% | 7,759,222.5 | 44,981 NS |
|---|
| Humana Inc | Humana Inc | 0.657670108124% | 7,477,617.14 | 43,126 NS |
|---|
| Revolution Medicines Inc | Revolution Medicines Inc | 0.65509842829% | 7,448,377.5 | 76,590 NS |
|---|
| GRAIL Inc | GRAIL Inc | 0.653735043004% | 7,432,876 | 143,825 NS |
|---|
| Corbus Pharmaceuticals Holdings Inc | Corbus Pharmaceuticals Holdings Inc | 0.642550656516% | 7,305,711.09 | 778,031 NS |
|---|
| Boston Scientific Corp | Boston Scientific Corp | 0.63719352465% | 7,244,801.25 | 115,455 NS |
|---|
| LENZ Therapeutics Inc | LENZ Therapeutics Inc | 0.631241881513% | 7,177,131.9 | 784,386 NS |
|---|
| Arcutis Biotherapeutics Inc | Arcutis Biotherapeutics Inc | 0.626633256657% | 7,124,732.48 | 302,408 NS |
|---|
| Nuvalent Inc | Nuvalent Inc | 0.611670967932% | 6,954,613.35 | 67,883 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.606867623882% | 6,900,000 | 2,875,000 NS |
|---|
| Palvella Therapeutics Inc | Palvella Therapeutics Inc | 0.600333625296% | 6,825,709.35 | 54,759 NS |
|---|
| Cogent Biosciences Inc | Cogent Biosciences Inc | 0.591859581736% | 6,729,360.66 | 174,834 NS |
|---|
| NeoGenomics Inc | NeoGenomics Inc | 0.590508092815% | 6,713,994.42 | 904,851 NS |
|---|
| Bristol-Myers Squibb Co | Bristol-Myers Squibb Co | 0.57348827746% | 6,520,481.5 | 107,510 NS |
|---|
| Arcus Biosciences Inc | Arcus Biosciences Inc | 0.570516780923% | 6,486,696 | 300,310 NS |
|---|
| Molina Healthcare Inc | Molina Healthcare Inc | 0.567206098155% | 6,449,054 | 48,380 NS |
|---|
| Soleno Therapeutics Inc | Soleno Therapeutics Inc | 0.559482122749% | 6,361,233.48 | 190,001 NS |
|---|
| Dexcom Inc | Dexcom Inc | 0.522605162499% | 5,941,947.6 | 94,617 NS |
|---|
| Ionis Pharmaceuticals Inc | Ionis Pharmaceuticals Inc | 0.521079497293% | 5,924,601 | 78,900 NS |
|---|
| IMMUNIC INC. | IMMUNIC INC. | 0.512270325599% | 5,824,441.95 | 5,247,245 NS |
|---|
| Apogee Therapeutics Inc | Apogee Therapeutics Inc | 0.492574525698% | 5,600,503.46 | 66,538 NS |
|---|
| Tandem Diabetes Care Inc | Tandem Diabetes Care Inc | 0.486018588407% | 5,525,963.37 | 288,261 NS |
|---|
| CVS Health Corp | CVS Health Corp | 0.479513360624% | 5,451,999.84 | 75,912 NS |
|---|
| Fulcrum Therapeutics Inc | Fulcrum Therapeutics Inc | 0.467792781083% | 5,318,738.49 | 693,447 NS |
|---|
| Immunic Inc | Immunic Inc | 0.462629772978% | 5,260,035.81 | 4,738,771 NS |
|---|
| THIRD ARC BIO, INC | THIRD ARC BIO, INC | 0.445915631568% | 5,069,998.36 | 2,409,466 NS |
|---|
| Krystal Biotech Inc | Krystal Biotech Inc | 0.425426693501% | 4,837,042 | 18,725 NS |
|---|
| GeneDx Holdings Corp | GeneDx Holdings Corp | 0.415424352336% | 4,723,316.78 | 73,549 NS |
|---|
| Guardant Health Inc | Guardant Health Inc | 0.405433734271% | 4,609,724.85 | 49,905 NS |
|---|
| IMMUNIC | IMMUNIC | 0.377558650812% | 4,292,789.05 | 8,847,463 NS |
|---|
| State Street Global Advisors | State Street Global Advisors | 0.370855852436% | 4,216,579.17 | 4,216,579.17 NS |
|---|
| Tempus AI Inc | Tempus AI Inc | 0.360420162932% | 4,097,926.84 | 90,622 NS |
|---|
| Rhythm Pharmaceuticals Inc | Rhythm Pharmaceuticals Inc | 0.359128560412% | 4,083,241.5 | 46,950 NS |
|---|
| Acadia Healthcare Co Inc | Acadia Healthcare Co Inc | 0.34914684571% | 3,969,750.8 | 169,720 NS |
|---|
| ICON PLC | ICON PLC | 0.348072318859% | 3,957,533.58 | 35,763 NS |
|---|
| GLYCOMINE, INC. | GLYCOMINE, INC. | 0.347489235169% | 3,950,904 | 6,584,840 NS |
|---|
| Ascendis Pharma A/S | Ascendis Pharma A/S | 0.340725388549% | 3,874,000.01 | 16,937 NS |
|---|
| Becton Dickinson & Co | Becton Dickinson & Co | 0.338235345604% | 3,845,688.57 | 24,459 NS |
|---|
| IMMUNIC INC. | IMMUNIC INC. | 0.335144784277% | 3,810,549.32 | 5,247,245 NS |
|---|
| QUELL THERAPEUTICS | QUELL THERAPEUTICS | 0.32893969651% | 3,739,998.34 | 1,798,941 NS |
|---|
| QLARIS BIO, INC. | QLARIS BIO, INC. | 0.303433780278% | 3,449,999.64 | 4,394,904 NS |
|---|
| ARBOR BIOTECHNOLOGIES | ARBOR BIOTECHNOLOGIES | 0.299036000584% | 3,399,997.5 | 827,250 NS |
|---|
| IQVIA Holdings Inc | IQVIA Holdings Inc | 0.295351314974% | 3,358,103.14 | 19,691 NS |
|---|
| Maze Therapeutics Inc | Maze Therapeutics Inc | 0.293426221811% | 3,336,215.1 | 111,766 NS |
|---|
| Ocular Therapeutix Inc | Ocular Therapeutix Inc | 0.280338845333% | 3,187,413.46 | 376,318 NS |
|---|
| ENDEAVOR BIOMEDICINES, INC. | ENDEAVOR BIOMEDICINES, INC. | 0.272650344418% | 3,099,996.28 | 657,322 NS |
|---|
| RECODE THERAPEUTICS | RECODE THERAPEUTICS | 0.269132819176% | 3,060,002.51 | 331,413 NS |
|---|
| AgomAb Therapeutics NV | AgomAb Therapeutics NV | 0.268360012835% | 3,051,215.81 | 290,869 NS |
|---|
| ABCURO, INC. | ABCURO, INC. | 0.257259101428% | 2,925,000 | 532,816 NS |
|---|
| SEISMIC THERAPEUTICS, INC. | SEISMIC THERAPEUTICS, INC. | 0.257257607126% | 2,924,983.01 | 647,722 NS |
|---|
| WaVe Life Sciences Ltd | WaVe Life Sciences Ltd | 0.255060305689% | 2,900,000 | 400,000 NS |
|---|
| ENGRAIL THERAPEUTICS INC. SERI | ENGRAIL THERAPEUTICS INC. SERI | 0.250011138034% | 2,842,591.67 | 4,768,649 NS |
|---|
| EVOMMUNE | EVOMMUNE | 0.244734290358% | 2,782,594.65 | 121,035 NS |
|---|
| Sera Prognostics Inc | Sera Prognostics Inc | 0.231353751083% | 2,630,459.79 | 1,295,793 NS |
|---|
| AMOLYT MILESTONE | AMOLYT MILESTONE | 0.224510911407% | 2,552,657.66 | 15,982.08 NS |
|---|
| InspireMD Inc | InspireMD Inc | 0.215546712301% | 2,450,735.97 | 1,503,519 NS |
|---|
| CRYSTALYS THERAPEUTICS SER A | CRYSTALYS THERAPEUTICS SER A | 0.205174002464% | 2,332,799.71 | 2,328,492 NS |
|---|
| Twist Bioscience Corp | Twist Bioscience Corp | 0.20396654082% | 2,319,071.04 | 48,802 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.1802595359% | 2,049,525.71 | 632,394 NS |
|---|
| Immunocore Holdings PLC | Immunocore Holdings PLC | 0.177444346475% | 2,017,517.4 | 66,916 NS |
|---|
| SpyGlass Pharma Inc | SpyGlass Pharma Inc | 0.166477785885% | 1,892,829.14 | 73,054 NS |
|---|
| Waters Corp | Waters Corp | 0.162364547949% | 1,846,062.2 | 6,199 NS |
|---|
| McKesson Corp | McKesson Corp | 0.15564494022% | 1,769,661.2 | 2,045 NS |
|---|
| NUVIG THERAPEUTICS, INC | NUVIG THERAPEUTICS, INC | 0.151716751175% | 1,724,998.24 | 1,644,892 NS |
|---|
| ATALANTA THERAPEUTICS | ATALANTA THERAPEUTICS | 0.140722944867% | 1,600,000.2 | 1,777,778 NS |
|---|
| INCENDIA THERAPEUTICS, INC. | INCENDIA THERAPEUTICS, INC. | 0.138016649481% | 1,569,230 | 1,569,230 PA |
|---|
| INVETX MILESTONE INTEREST | INVETX MILESTONE INTEREST | 0.136660695246% | 1,553,812.99 | 31,194.8 NS |
|---|
| CURASEN THERAPEUTICS, INC. | CURASEN THERAPEUTICS, INC. | 0.135779328203% | 1,543,791.97 | 3,219,587 NS |
|---|
| Tenet Healthcare Corp | Tenet Healthcare Corp | 0.13490358392% | 1,533,834.88 | 8,128 NS |
|---|
| ARBOR BIOTECHNOLOGIES | ARBOR BIOTECHNOLOGIES | 0.119614428378% | 1,359,999.32 | 82,076 NS |
|---|
| HIBERCELL, INC. SERIES B | HIBERCELL, INC. SERIES B | 0.100621923847% | 1,144,057.2 | 2,773,472 NS |
|---|
| ENDEAVOR BIOMEDICINES INC. | ENDEAVOR BIOMEDICINES INC. | 0.069652252627% | 791,936.37 | 121,377 NS |
|---|
| HOTSPOT THERAPEUTICS, INC. | HOTSPOT THERAPEUTICS, INC. | 0.063401981366% | 720,871.66 | 720,871.66 PA |
|---|
| ABCURO INC. | ABCURO INC. | 0.06263223399% | 712,119.74 | 117,926 NS |
|---|
| HIBERCELL,INC. SERIES C | HIBERCELL,INC. SERIES C | 0.062354804016% | 708,965.4 | 1,529,261 NS |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 0.059807244092% | 680,000 | 680,000 PA |
|---|
| BIOTHERYX, INC. SERIES E | BIOTHERYX, INC. SERIES E | 0.057563044101% | 654,483.76 | 1,295,238 NS |
|---|
| Incendia Therapeutics, Inc. | Incendia Therapeutics, Inc. | 0.056443544841% | 641,755.21 | 1,769,383 NS |
|---|
| OCULIS HOLDINGS AG | OCULIS HOLDINGS AG | 0.049466895251% | 562,431.68 | 21,152 NS |
|---|
| INCENDIA THERAPEUTICS, INC. | INCENDIA THERAPEUTICS, INC. | 0.048142231638% | 547,370.44 | 547,370.44 PA |
|---|
| AVICEDA THERAPEUTICS | AVICEDA THERAPEUTICS | 0.043869749879% | 498,792.92 | 86,599 NS |
|---|
| HIBERCELL, INC. | HIBERCELL, INC. | 0.038611029075% | 439,002 | 439,002 PA |
|---|
| QLARIS BIO, INC. | QLARIS BIO, INC. | 0.037503979396% | 426,415 | 426,415 PA |
|---|
| RECODE THERAPEUTICS, INC. | RECODE THERAPEUTICS, INC. | 0.01419282983% | 161,370.49 | 161,370.49 PA |
|---|
| TScan Therapeutics Inc | TScan Therapeutics Inc | 0.010547567748% | 119,924.37 | 118,737 NS |
|---|
| CONTRA CHINOOK THERAPE | CONTRA CHINOOK THERAPE | 0.002583672944% | 29,376 | 91,800 NS |
|---|
| CONTRA FUSION PHARMACE | CONTRA FUSION PHARMACE | 0.000921589173% | 10,478.34 | 7,593 NS |
|---|
| Vir Biotechnology Inc | Vir Biotechnology Inc | 0.000078804839% | 896 | 100 NS |
|---|
| IO LIGHT HOLDINIGS, INC. | IO LIGHT HOLDINIGS, INC. | 0.000003708049% | 42.16 | 421,634 NS |
|---|
| PRIOTHERA LIMITED | PRIOTHERA LIMITED | 0.000003524229% | 40.07 | 346,666 NS |
|---|
| Willow Laboratories Inc. | Willow Laboratories Inc. | 0.000001407229% | 16 | 160,000 NS |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 4.82855e-7% | 5.49 | 5,487,525 NS |
|---|
| HIBERCELL, INC. SERIES C | HIBERCELL, INC. SERIES C | 1.34566e-7% | 1.53 | 1,529,261 NS |
|---|
| Afferent Milestone Interest | Afferent Milestone Interest | 2.638e-9% | 0.03 | 26,208.04 NS |
|---|
| RECODE THERAPEUTICS, INC. | RECODE THERAPEUTICS, INC. | 0% | 0 | 161,371 NS |
|---|
| ETHISMOS RESEARCH, INC. MILEST | ETHISMOS RESEARCH, INC. MILEST | 0% | 0 | 1,180 NS |
|---|
| AMPHIVENA MILESTONE INTEREST | AMPHIVENA MILESTONE INTEREST | 0% | 0 | 100 NS |
|---|
| HIBERCELL INC. | HIBERCELL INC. | 0% | 0 | 8,500,000 NS |
|---|
| Options Clearing Corp. | Options Clearing Corp. | -0.00065172305% | -7,410 | -247 NC |
|---|