BBH additions & removals
Changes are observation-bounded: an addition is the first retained official snapshot containing a security after an earlier absence; a removal is its first retained absence. Baseline holdings receive no invented addition date.
Additions
| Ticker | Issuer | Observed date | Change |
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| Revolution Medicines Inc | Revolution Medicines Inc | 2026-03-31 | Added / first present |
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| State Street Global Advisors | State Street Global Advisors | 2025-12-31 | Added / first present |
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| United Therapeutics Corp | United Therapeutics Corp | 2025-09-30 | Added / first present |
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| Tempus AI Inc | Tempus AI Inc | 2025-09-30 | Added / first present |
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| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2025-03-31 | Added / first present |
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| Insmed Inc | Insmed Inc | 2024-09-30 | Added / first present |
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| State Street Global Advisors | State Street Global Advisors | 2024-06-30 | Added / first present |
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| GRAIL Inc | GRAIL Inc | 2024-06-30 | Added / first present |
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| Neurocrine Biosciences Inc | Neurocrine Biosciences Inc | 2024-03-31 | Added / first present |
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| Cytokinetics Inc | Cytokinetics Inc | 2024-03-31 | Added / first present |
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| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 2023-03-31 | Added / first present |
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| Repligen Corp | Repligen Corp | 2022-09-30 | Added / first present |
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| Argenx SE | Argenx SE | 2022-09-30 | Added / first present |
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| State Street Global Advisors | State Street Global Advisors | 2021-12-31 | Added / first present |
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| Natera Inc | Natera Inc | 2021-09-30 | Added / first present |
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| Intellia Therapeutics Inc | Intellia Therapeutics Inc | 2021-09-30 | Added / first present |
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| Bio-Techne Corp | Bio-Techne Corp | 2021-09-30 | Added / first present |
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| 10X Genomics Inc | 10X Genomics Inc | 2021-03-31 | Added / first present |
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| Seagen Inc | Seagen Inc | 2020-12-31 | Added / first present |
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| Immunomedics Inc | Immunomedics Inc | 2020-09-30 | Added / first present |
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| Quidel Corp | Quidel Corp | 2020-09-30 | Added / first present |
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| Novavax Inc | Novavax Inc | 2020-09-30 | Added / first present |
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| BioNTech SE | BioNTech SE | 2020-09-30 | Added / first present |
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| State Street Global Advisors | State Street Global Advisors | 2020-03-31 | Added / first present |
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| Moderna Inc | Moderna Inc | 2020-03-31 | Added / first present |
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| BeiGene Ltd | BeiGene Ltd | 2019-12-31 | Added / first present |
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| Vertex Pharmaceuticals Inc | Vertex Pharmaceuticals Inc | 2019-12-31 | Added / first present |
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| Gilead Sciences Inc | Gilead Sciences Inc | 2019-12-31 | Added / first present |
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| Biogen Inc | Biogen Inc | 2019-12-31 | Added / first present |
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| Amgen Inc | Amgen Inc | 2019-12-31 | Added / first present |
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| Illumina Inc | Illumina Inc | 2019-12-31 | Added / first present |
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| Regeneron Pharmaceuticals Inc | Regeneron Pharmaceuticals Inc | 2019-12-31 | Added / first present |
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| Alexion Pharmaceuticals Inc | Alexion Pharmaceuticals Inc | 2019-12-31 | Added / first present |
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| Incyte Corp | Incyte Corp | 2019-12-31 | Added / first present |
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| Seattle Genetics Inc | Seattle Genetics Inc | 2019-12-31 | Added / first present |
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| BioMarin Pharmaceutical Inc | BioMarin Pharmaceutical Inc | 2019-12-31 | Added / first present |
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| Exact Sciences Corp | Exact Sciences Corp | 2019-12-31 | Added / first present |
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| Alnylam Pharmaceuticals Inc | Alnylam Pharmaceuticals Inc | 2019-12-31 | Added / first present |
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| Ionis Pharmaceuticals Inc | Ionis Pharmaceuticals Inc | 2019-12-31 | Added / first present |
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| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 2019-12-31 | Added / first present |
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| Neurocrine Biosciences Inc | Neurocrine Biosciences Inc | 2019-12-31 | Added / first present |
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| Bluebird Bio Inc | Bluebird Bio Inc | 2019-12-31 | Added / first present |
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| United Therapeutics Corp | United Therapeutics Corp | 2019-12-31 | Added / first present |
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| Charles River Laboratories International Inc | Charles River Laboratories International Inc | 2019-12-31 | Added / first present |
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| IQVIA Holdings Inc | IQVIA Holdings Inc | 2019-12-31 | Added / first present |
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| Guardant Health Inc | Guardant Health Inc | 2019-12-31 | Added / first present |
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| Grifols SA | Grifols SA | 2019-12-31 | Added / first present |
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Removals
| Ticker | Issuer | Observed date | Change |
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| Intra-Cellular Therapies Inc | Intra-Cellular Therapies Inc | 2025-06-30 | Removed / first absent |
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| State Street Global Advisors | State Street Global Advisors | 2024-09-30 | Removed / first absent |
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| GRAIL Inc | GRAIL Inc | 2024-09-30 | Removed / first absent |
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| Cytokinetics Inc | Cytokinetics Inc | 2025-03-31 | Removed / first absent |
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| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 2025-09-30 | Removed / first absent |
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| Repligen Corp | Repligen Corp | 2026-03-31 | Removed / first absent |
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| State Street Global Advisors | State Street Global Advisors | 2023-03-31 | Removed / first absent |
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| Intellia Therapeutics Inc | Intellia Therapeutics Inc | 2023-09-30 | Removed / first absent |
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| 10X Genomics Inc | 10X Genomics Inc | 2022-09-30 | Removed / first absent |
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| Seagen Inc | Seagen Inc | 2023-12-31 | Removed / first absent |
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| Immunomedics Inc | Immunomedics Inc | 2020-12-31 | Removed / first absent |
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| Quidel Corp | Quidel Corp | 2021-09-30 | Removed / first absent |
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| Novavax Inc | Novavax Inc | 2022-09-30 | Removed / first absent |
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| State Street Global Advisors | State Street Global Advisors | 2020-06-30 | Removed / first absent |
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| Alexion Pharmaceuticals Inc | Alexion Pharmaceuticals Inc | 2021-09-30 | Removed / first absent |
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| Seattle Genetics Inc | Seattle Genetics Inc | 2020-12-31 | Removed / first absent |
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| Exact Sciences Corp | Exact Sciences Corp | 2026-03-31 | Removed / first absent |
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| Ionis Pharmaceuticals Inc | Ionis Pharmaceuticals Inc | 2021-09-30 | Removed / first absent |
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| Sarepta Therapeutics Inc | Sarepta Therapeutics Inc | 2021-03-31 | Removed / first absent |
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| Neurocrine Biosciences Inc | Neurocrine Biosciences Inc | 2021-09-30 | Removed / first absent |
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| Bluebird Bio Inc | Bluebird Bio Inc | 2020-09-30 | Removed / first absent |
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| United Therapeutics Corp | United Therapeutics Corp | 2020-09-30 | Removed / first absent |
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| Guardant Health Inc | Guardant Health Inc | 2023-03-31 | Removed / first absent |
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| Grifols SA | Grifols SA | 2020-09-30 | Removed / first absent |
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| BGNE | BeiGene Ltd | 2019-12-31 | Removed / first absent |
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| BLUE | BLUEBIRD BIO INC | 2019-12-31 | Removed / first absent |
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| CELG | CELGENE CORP | 2019-12-31 | Removed / first absent |
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| AGN | ALLERGAN PLC | 2019-12-31 | Removed / first absent |
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| ALXN | ALEXION PHARMACEUTICALS INC | 2019-12-31 | Removed / first absent |
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| EXAS | Exact Sciences Corp | 2019-12-31 | Removed / first absent |
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| SGEN | SEATTLE GENETICS INC | 2019-12-31 | Removed / first absent |
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| ALNY | ALNYLAM PHARMACEUTICALS INC | 2019-12-31 | Removed / first absent |
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| AMGN | AMGEN INC | 2019-12-31 | Removed / first absent |
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| BIIB | BIOGEN INC | 2019-12-31 | Removed / first absent |
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| BMRN | BIOMARIN PHARMACEUTICAL INC | 2019-12-31 | Removed / first absent |
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| CRL | CHARLES RIVER LABORATORIES INTERNATIONAL INC | 2019-12-31 | Removed / first absent |
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| GH | Guardant Health Inc | 2019-12-31 | Removed / first absent |
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| GILD | GILEAD SCIENCES INC | 2019-12-31 | Removed / first absent |
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| GRFS | GRIFOLS SA | 2019-12-31 | Removed / first absent |
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| ILMN | ILLUMINA INC | 2019-12-31 | Removed / first absent |
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| INCY | INCYTE CORP | 2019-12-31 | Removed / first absent |
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| IONS | IONIS PHARMACEUTICALS INC | 2019-12-31 | Removed / first absent |
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| IQV | IQVIA HOLDINGS INC | 2019-12-31 | Removed / first absent |
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| NBIX | NEUROCRINE BIOSCIENCES INC | 2019-12-31 | Removed / first absent |
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| QGEN | QIAGEN NV | 2019-12-31 | Removed / first absent |
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| REGN | REGENERON PHARMACEUTICALS INC | 2019-12-31 | Removed / first absent |
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| SRPT | Sarepta Therapeutics Inc | 2019-12-31 | Removed / first absent |
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| UTHR | UNITED THERAPEUTICS CORP | 2019-12-31 | Removed / first absent |
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| VRTX | VERTEX PHARMACEUTICALS INC | 2019-12-31 | Removed / first absent |
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