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<url><loc>https://stock.noler.com/us/stock/vrtx/oci-available-for-sale-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-before-reclassifications-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-before-reclassifications-net-of-tax-attributable-to-parent</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-cash-flow-hedge-gain-loss-after-reclassification-and-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-cash-flow-hedge-gain-loss-after-reclassification-and-tax-parent</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-cash-flow-hedge-gain-loss-after-reclassification-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-cash-flow-hedge-gain-loss-after-reclassification-tax-parent</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-derivatives-qualifying-as-hedges-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-derivatives-qualifying-as-hedges-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-foreign-currency-transaction-and-translation-gain-loss-arising-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-net-of-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-net-of-tax-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-securities-sale-reclassification-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-unrealized-gain-loss-on-derivatives-arising-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-unrealized-gain-loss-on-derivatives-arising-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-unrealized-holding-gain-loss-on-securities-arising-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/oci-unrealized-holding-gain-loss-on-securities-arising-tax</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-liability-current</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-future-minimum-sublease-rentals</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-in-five-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-in-four-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-in-three-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-in-two-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-thereafter</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-payments-due-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-lease-weighted-average-discount-rate-percent</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-leases-future-minimum-payments-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-leases-rent-expense-sublease-rentals</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-loss-carryforwards</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/operating-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/options-activity</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-accrued-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-current-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-indefinite-lived-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-noncash-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-noncash-income-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-noncurrent-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-noncurrent-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-nonoperating-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-nonoperating-income-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-sundry-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/other-sundry-liabilities-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/outstanding-bonds</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/paid-in-capital-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/paid-in-capital-shares-issued-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/paid-in-capital-stock-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/paid-in-capital-tax-effect-from-share-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/patents-active</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-for-derivative-instrument-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-for-proceeds-from-other-investing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-for-restructuring</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-of-debt-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-of-debt-restructuring-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-of-financing-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-available-for-sale-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-equity-securities-fv-ni</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-in-process-research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-marketable-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/payments-to-acquire-notes-receivable</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/pb-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/pe-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/pre-tax-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/preferred-shares-facts</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/preferred-stock-par-or-stated-value-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/preferred-stock-shares-authorized</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/preferred-stock-shares-issued</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/preferred-stock-value</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/prepaid-expense-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/pretax-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/pretax-income-domestic</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/pretax-income-minority-interest-and-income-loss-from-equity-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/previous-etf-holding-it</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/price-fcf-ratio</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-issuance-of-shares-under-incentive-and-share-based-compensation-plans-including-stock-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-lines-of-credit</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-payments-for-other-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-repayments-of-restricted-cash-financing-activities</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-sale-and-maturity-of-other-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-sale-of-available-for-sale-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-sale-of-equity-securities-fv-ni</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-sale-of-trading-securities-heldforinvestment</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-stock-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/proceeds-from-stock-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/profit-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/profit-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-and-equipment-and-finance-lease-right-of-use-asset-accumulated-depreciation-and-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-and-equipment-and-finance-lease-right-of-use-asset-after-accumulated-depreciation-and-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-and-equipment-and-finance-lease-right-of-use-asset-before-accumulated-depreciation-and-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-and-equipment-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-and-equipment-gross-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/property-plant-equipment</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/public-float</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/realized-investment-gains-losses</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/reclassification-from-accumulated-oci-current-period-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/reclassification-from-aoci-current-period-net-of-tax-attributable-to-parent</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-advances-for-construction</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-construction-loans-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-lines-of-credit</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/repayments-of-secured-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/research-and-development-asset-acquired-other-than-through-acquisition-written-off</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-and-related-cost-expected-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-reserve</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-reserve-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-reserve-current</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/restructuring-reserve-settled-with-cash</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/retained-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/return-on-tangible-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/revenue-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/revenues</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/right-of-use-asset-obtained-in-exchange-for-finance-lease-liability</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/roa</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/roe</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/roi</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/royalty-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sales-revenue-goods-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/scorecard</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-comment-letters-upload</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-enforcement-actions</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-filings-10-q</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-filings-25-nse</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-filings-8-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-filings-px14a6g</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sec-filings-s-4</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/secondary-offerings</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/secured-debt</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/senior-notes-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/sga-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-exercisable-options-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-number-of-exercisable-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-number-of-outstanding-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-outstanding-options-average-exercise-price-beginning-balance</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-outstanding-options-average-exercise-price-beginning-balance-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/share-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/shareholders-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/shares-authorized</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/shares-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/shares-issued-shares-new-issues</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/shares-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/short-sale-volume</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/significant-change-in-utb-is-reasonably-possible-amount-of-unrecorded-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-number-of-shares-available-for-grant</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-options-exercises-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-options-expirations-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-options-forfeitures-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-options-grants-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-forfeited-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-forfeited-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-forfeitures-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-grants-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-grants-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-nonvested-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-nonvested-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-vested-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-vested-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-award-rsu-vested-in-period-total-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-compensation-allocation-of-recognized-period-costs-capitalized-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-compensation-cash-received-from-exercise-of-stock-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-compensation-tax-benefit-from-compensation-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-compensation-unrecognized-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-new-shares-sold</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-shares-issued-for-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-shares-issued-shares-employee-benefit-plan</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-shares-issued-value-conversion-of-convertible-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-shares-issued-value-employee-benefit-plan</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-issued-value-of-shares-issued-for-acquisitions</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercisable-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercisable-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercisable-intrinsic-value-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercisable-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercisable-remaining-term</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercises-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercises-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-exercises-in-period-total-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-expirations-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-expirations-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-forfeitures-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-forfeitures-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-grants-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-grants-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-grants-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-grants-in-period-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-outstanding-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-outstanding-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-outstanding-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-outstanding-remaining-term</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/stock-options-vested-and-expected-to-vest-outstanding-aggregate-intrinsic-value</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/stockholders-equity-including-portion-attributable-to-noncontrolling-interest</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/sublease-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/subordinated-borrowing-interest-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/subsidiaries</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-credit-carryforward-amount</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-fdii-amount</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-repatriation-of-foreign-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-share-based-compensation-excess-tax-benefit-amount</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-tax-credits</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-tax-credits-research</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-rate-reconciliation-tax-exempt-income</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-minority-interest-income-expense</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-nondeductible-expense-research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-nondeductible-expense-share-based-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-other-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-state-and-local-income-taxes</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-tax-contingencies</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/tax-reconciliation-tax-exempt-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/tax-withholding-on-stock-awards</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/taxes-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/temporary-equity-issue-period-increase-or-decrease</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/total-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/total-contract-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/total-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/total-liabilities-and-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/total-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/ttl-fee-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/ttl-offering-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/ttl-offset-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/undistributed-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/undistributed-earnings-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/undistributed-earnings-loss-allocated-to-participating-securities-basic</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unrealized-gain-loss-on-derivatives</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unrealized-gain-loss-on-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unrealized-gain-loss-on-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unrecognized-deferred-tax-liability-foreign-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unrecognized-tax-benefits</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/unusual-or-infrequent-item-earnings-per-share-impact-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/us-government-securities-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-change</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/utb-decrease-from-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-income-tax-penalties-and-interest-accrued</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-income-tax-penalties-and-interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-increase-from-current-year-positions</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/utb-reduction-from-statute-lapse</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-resulting-in-net-operating-loss-carryforward</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/utb-that-would-impact-effective-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/valuation-allowance-deferred-tax-asset-change-in-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/valuation-allowances-and-reserves-adjustments</loc></url>
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<url><loc>https://stock.noler.com/us/stock/vrtx/variable-lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/weighted-average-number-of-share-outstanding-basic-and-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/vrtx/write-off-of-deferred-debt-issuance-cost</loc></url>
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