<?xml version="1.0" encoding="UTF-8"?>
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9">
<url><loc>https://stock.noler.com/us/stock/shire-plc</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-payable-and-accrued-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-payable-related-parties-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-payable-related-parties-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-payable-trade-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accounts-receivable-related-parties</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrual-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrual-provision</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-advertising-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-advertising-current-and-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-bonuses-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-bonuses-current-and-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-income-taxes-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-income-taxes-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-marketing-costs-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accrued-rent-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accumulated-depreciation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accumulated-oci-available-for-sale-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accumulated-oci-cumulative-changes-in-net-gain-loss-from-cash-flow-hedges-effect-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accumulated-oci-defined-benefit-pension-and-other-postretirement-plans-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/accumulated-oci-foreign-currency-translation-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/acquired-finite-lived-intangible-asset-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/acquired-finite-lived-intangible-asset-weighted-average-useful-life</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/acquisition-acquisition-related-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/acquisition-contingent-consideration-arrangements-change-in-amount-of-contingent-consideration-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/acquisitions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/activist-13d-13g-form-sc-13d</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/activist-13d-13g-form-sc-13g</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/additional-paid-in-capital</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/additional-paid-in-capital-common-stock</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/additions-to-noncurrent-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/adjustment-to-additional-paid-in-capital-income-tax-effect-from-share-based-compensation-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/adjustments-noncash-items-to-reconcile-net-income-loss-to-cash-provided-by-used-in-operating-activities-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/advertising-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/allocated-share-based-compensation-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/allocated-share-based-compensation-expense-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/allowance-for-doubtful-accounts-receivable-charge-offs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/allowance-for-doubtful-accounts-receivable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/allowance-for-doubtful-accounts-receivable-write-offs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/amended-reports-10-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/amended-reports-10-q</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/amortization-of-financing-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/amortization-of-financing-costs-and-discounts</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/aoci</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/asset-impairment-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/assets-held-for-sale-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/assets-of-disposal-group-including-discontinued-operation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/available-for-sale-equity-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/available-for-sale-fair-value-disclosure</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/available-for-sale-gross-realized-gain-loss-excluding-other-than-temporary-impairments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/available-for-sale-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/basic-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/buildings-and-improvements-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-contingent-consideration-at-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-cost-of-acquired-entity-cash-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-pro-forma-income-loss-from-before-changes-in-accounting-and-extraordinary-items-net-of-tax-per-share-basic</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-pro-forma-income-loss-from-before-changes-in-accounting-and-extraordinary-items-net-of-tax-per-share-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-purchase-price-allocation-current-liabilities-other-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisition-purchase-price-allocation-goodwill-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisitions-pro-forma-income-loss-from-before-changes-in-accounting-and-extraordinary-items-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/business-acquisitions-pro-forma-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/buybacks-share-repurchases</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/buybacks-treasury-stock-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/capital-expenditures</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/capital-lease-obligations-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/capital-lease-obligations-incurred</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/capital-lease-obligations-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-and-cash-equivalents-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-and-equivalents</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-and-restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-flow-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-flow-hedge-gain-loss-to-be-reclassified-within-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cash-provided-by-used-in-operating-activities-discontinued-operations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/commitments-and-contingencies</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-dividends-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-stock-dividends-per-share-cash-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-stock-par-or-stated-value-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-stock-shares-held-in-employee-trust</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-stock-shares-held-in-employee-trust-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/common-stock-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/comprehensive-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/comprehensive-income-net-of-tax-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/comprehensive-income-net-of-tax-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/congressional-trades-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/construction-in-progress-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/contract-with-customer-asset-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/convertible-debt-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/convertible-debt-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cost-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cost-of-goods-sold</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cost-of-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/costmethod-investments-realized-gain-loss-excluding-other-than-temporary-impairments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cover-page-shares-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/cumulative-effect-of-new-accounting-principle-in-period-of-adoption</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/current-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/current-federal-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/current-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/current-state-and-local-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-and-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-carrying-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-convertible-conversion-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-convertible-effective-interest-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-convertible-number-of-equity-instruments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-face-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-interest-rate-stated-percentage</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-longterm-and-shortterm-combined-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-in-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-in-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-in-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-in-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-maturing-in-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-repaid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/debt-unamortized-discount-premium-and-debt-issuance-costs-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-federal-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-finance-costs-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-other-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-revenue-additions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-revenue-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-state-and-local-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-deferred-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-goodwill-and-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-liabilities-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-net-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-net-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-stock-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-tax-deferred-expense-compensation-and-benefits-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-tax-deferred-expense-reserves-and-accruals-accrued-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-tax-deferred-expense-reserves-and-accruals-allowance-for-doubtful-accounts</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-tax-deferred-expense-reserves-and-accruals-restructuring-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-assets-valuation-allowance</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities-deferred-expense-capitalized-inventory-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities-goodwill-and-intangible-assets-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liabilities-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/deferred-tax-liability-not-recognized-cumulative-amount-of-temporary-difference</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/defined-benefit-plan-assumptions-used-calculating-net-periodic-benefit-cost-expected-long-term-return-on-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/defined-contribution-plan-employer-discretionary-contribution-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/depreciation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/depreciation-and-amortization-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-asset-fair-value-gross-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-asset-fair-value-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-gross-amount-not-offset-against-collateral-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-of-derivative-asset</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-of-derivative-asset-amount-not-offset-against-collateral</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-of-derivative-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-of-derivative-liability-amount-not-offset-against-collateral</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-fair-value-of-derivative-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-gain-loss-recognized-in-income-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-liability-fair-value-gross-asset</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-liability-fair-value-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-notional-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/derivative-number-of-instruments-held</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/diluted-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/discontinued-operation-gain-loss-from-disposal-of-discontinued-operation-before-income-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/discontinued-operation-tax-effect-of-discontinued-operation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/disposal-group-including-discontinued-operation-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/disposal-group-including-discontinued-operation-intangible-assets-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/dividends-common-stock-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/dividends-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/dividends-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/effect-of-exchange-rate-on-cash-and-restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/effective-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/employee-related-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/entity-wide-revenue-major-customer-percentage</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/eps</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/eps-basic</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/equity-method-investment-dividends-or-distributions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/equity-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/excess-tax-benefit-from-share-based-compensation-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/exchange-rate-effect-on-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/extinguishment-of-debt-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/fair-value-inputs-discount-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/fair-value-measurement-with-unobservable-inputs-reconciliation-liability-transfers-into-level</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/fair-value-measurement-with-unobservable-inputs-reconciliation-liability-transfers-out-of-level</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/fair-value-measurement-with-unobservable-inputs-reconciliations-recurring-basis-liability-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/financing-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-contractual-rights-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-accumulated-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-amortization-expense-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-future-amortization-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-purchase-accounting-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-useful-life-maximum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-useful-life-minimum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finite-lived-intangible-assets-weighted-average-useful-life</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/finitelived-intangible-assets-acquired</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-currency-contract-asset-fair-value-disclosure</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-currency-contracts-liability-fair-value-disclosure</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-currency-non-hedging-derivatives-asset-at-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-currency-non-hedging-derivatives-liability-at-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-currency-transaction-gain-loss-before-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/foreign-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/furniture-and-fixtures-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gain-loss-on-disposition-of-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gain-loss-on-sale-of-business</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gain-loss-on-sale-of-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gain-loss-on-sale-of-other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gain-loss-on-sales-of-assets-and-asset-impairment-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gains-losses-on-extinguishment-of-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/gains-losses-on-sales-of-other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-acquired</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-foreign-currency-translation-gain-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-impaired-accumulated-impairment-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-impairment-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-transfers</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-translation-and-purchase-accounting-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/goodwill-written-off-related-to-sale-of-business-unit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-intangible-assets-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-intangible-assets-finitelived</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-intangible-assets-indefinitelived-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-long-lived-assets-held-for-use</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/impairment-of-long-lived-assets-to-be-disposed-of</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-discontinued-operations-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-discontinued-operations-net-of-tax-attributable-to-reporting-entity</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-discontinued-operations-net-of-tax-per-basic-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-discontinued-operations-net-of-tax-per-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-equity-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-per-basic-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-loss-from-per-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-tax-effects-allocated-directly-to-equity-employee-stock-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-tax-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-taxes-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/income-taxes-paid-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-accounts-payable-and-accrued-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-accounts-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-deferred-income-taxes</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-deferred-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-inventories</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-other-accrued-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-other-operating-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-prepaid-deferred-expense-and-other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/increase-decrease-in-restricted-cash-for-operating-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/incremental-common-shares-attributable-to-conversion-of-debt-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/incremental-common-shares-attributable-to-share-based-payment-arrangements</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/indefinite-lived-intangible-assets-excluding-goodwill-fair-value-disclosure</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/intangible-assets-gross-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/intangible-assets-net-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-expense-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-income-deposits-with-financial-institutions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-income-expense-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-on-convertible-debt-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/interest-paid-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-finished-goods</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-finished-goods-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-raw-materials</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-raw-materials-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-work-in-process</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-work-in-process-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/inventory-write-down</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/investing-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/land</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/lease-and-rental-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/letters-of-credit-outstanding-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-gain-loss-included-in-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-gain-loss-included-in-earnings-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-gain-loss-included-in-oci-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-gain-loss-included-in-other-comprehensive-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-transfers-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-transfers-out-of-level</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-asset-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-liability-gain-loss-included-in-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-liability-gain-loss-included-in-other-comprehensive-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-liability-purchases</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-liability-purchases-sales-issuances-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/level-3-liability-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/line-of-credit-facility-amount-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/line-of-credit-facility-commitment-fee-percentage</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/line-of-credit-facility-maximum-borrowing-capacity</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/litigation-reserve-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/litigation-settlement-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/litigation-settlement-amount-awarded-to-other-party</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-in-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-in-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-in-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-in-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-maturities-repayments-of-principal-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-debt-and-capital-lease-obligations-repayments-of-principal-in-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/long-term-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/machinery-and-equipment-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/minority-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/minority-interest-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/minority-interest-decrease-from-redemptions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/minority-interest-increase-from-stock-issuance</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/net-cash-from-operating-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/net-change-in-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/net-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/net-income-loss-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/net-income-loss-available-to-common-stockholders-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/non-hedging-derivatives-gain-loss-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/noncash-or-part-noncash-divestiture-amount-of-consideration-received</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/noncash-or-part-noncash-divestiture-amount-of-consideration-received-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/noncurrent-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/number-of-operating-segments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/number-of-reportable-segments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-available-for-sale-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-before-reclassifications-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-defined-benefit-plans-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-defined-benefit-plans-net-unamortized-gain-loss-arising-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-derivatives-qualifying-as-hedges-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-derivatives-qualifying-as-hedges-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-pension-and-other-postretirement-benefit-plans-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-for-write-down-of-securities-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-for-write-down-of-securities-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-for-write-down-of-securities-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-for-writedown-of-securities-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-from-aoci-for-sale-of-securities-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-from-aoci-for-sale-of-securities-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-from-aoci-for-writedown-of-securities-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-reclassification-adjustment-from-aoci-for-writedown-of-securities-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-securities-sale-reclassification-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-securities-sale-reclassification-net-of-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-securities-sale-reclassification-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-securities-sale-reclassification-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-unrealized-holding-gain-loss-on-securities-arising-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/oci-unrealized-holding-gain-loss-on-securities-arising-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-expenses</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-in-five-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-in-four-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-in-three-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-in-two-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-lease-payments-due-thereafter</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-leases-future-minimum-payments-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/operating-loss-carryforwards</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-accrued-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-accrued-liabilities-current-and-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-accrued-liabilities-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-assets-held-for-sale</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-current-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-general-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-indefinite-lived-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-interest-and-dividend-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-inventory-capitalized-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-long-term-debt-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-long-term-debt-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-noncash-income-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-noncurrent-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-noncurrent-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-noncurrent-liabilities-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-nonoperating-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-nonoperating-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-nonoperating-income-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-sales-revenue-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-short-term-borrowings</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-sundry-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-sundry-liabilities-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/other-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/paid-in-capital-shares-issued-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/paid-in-capital-stock-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/paid-in-capital-tax-effect-from-share-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payment-for-contingent-consideration-liability-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-for-hedge-investing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-for-legal-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-for-proceeds-from-other-investing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-for-proceeds-from-short-term-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-for-restructuring</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-of-debt-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-of-financing-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-of-stock-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-to-acquire-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-to-acquire-interest-in-subsidiaries-and-affiliates</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-to-acquire-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/payments-to-acquire-other-property-plant-and-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/pension-contributions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/pledged-assets-separately-reported-securities-pledged-under-letter-of-credit-facilities-at-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/pledged-financial-instruments-not-separately-reported-securities-for-letter-of-credit-facilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/prepaid-expense-and-other-assets-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/prepaid-expense-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/pretax-income-domestic</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/pretax-income-minority-interest-and-income-loss-from-equity-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-bank-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-collaborators</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-derivative-instrument-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-divestiture-of-businesses</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-divestiture-of-interest-in-subsidiaries-and-affiliates</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-equity-method-investment-dividends-or-distributions-return-of-capital</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-income-tax-refunds</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-lines-of-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-long-term-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-other-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-payments-for-other-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-repayments-of-related-party-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-sale-maturity-and-collection-of-shortterm-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-sale-of-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-sale-of-other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-sale-of-other-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-sale-of-property-plant-and-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-stock-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/proceeds-from-stock-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/profit-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/property-plant-and-equipment-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/property-plant-and-equipment-transfers-and-changes</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/property-plant-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/provision-for-doubtful-accounts</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/provision-for-other-losses</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/public-float</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/reclassification-from-accumulated-oci-current-period-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/reorganization-items</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/repayments-of-assumed-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/repayments-of-bank-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/repayments-of-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/repayments-of-lines-of-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/repayments-of-long-term-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/research-and-development-in-process</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restricted-cash-and-cash-equivalents-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-and-related-cost-cost-incurred-to-date</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-and-related-cost-cost-incurred-to-date-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-and-related-cost-expected-cost-remaining</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-reserve</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-reserve-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-reserve-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/restructuring-reserve-period-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/retained-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/revenue-from-contract-with-customer-excluding-assessed-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/revenues-from-external-customers</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/royalty-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sales-and-excise-tax-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sales-revenue-goods-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-comment-letters-corresp</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-comment-letters-upload</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-10-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-10-q</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-11-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-15-12b</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-15-15d</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-25</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-25-nse</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-425</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-8-a12b</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-8-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-certnys</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-ct-order</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-def-14a</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-defm14a</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-f-4</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-no-act</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-pre-14a</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-prem14a</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-prer14a</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-s-4</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-sc-to-c</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-sc-to-t</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sec-filings-sd</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-424b2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-424b3</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-424b5</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-effect</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-f-6</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-f-6-pos</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-f-6ef</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-fwp</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-pos-am</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-posasr</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-s-3</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-s-3asr</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-s-8</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secondary-offerings-form-s-8-pos</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secured-debt-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/secured-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/self-insurance-reserve-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/senior-long-term-notes</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/sga-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-exercisable-options-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/share-based-compensation-shares-authorized-under-stock-option-plans-exercise-price-range-number-of-exercisable-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/shareholders-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/shares-authorized</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/shares-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/shares-issued-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/short-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/significant-change-in-utb-is-reasonably-possible-amount-of-unrecorded-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-expected-term-maximum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-expected-term-minimum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-expected-volatility-rate-maximum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-expected-volatility-rate-minimum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-risk-free-interest-rate-maximum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-risk-free-interest-rate-minimum</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-fair-value-assumptions-weighted-average-volatility-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-plan-modification-incremental-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-rsu-aggregate-intrinsic-value-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-rsu-grants-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-rsu-grants-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-rsu-nonvested-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-award-rsu-outstanding-remaining-term</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-compensation-tax-benefit-from-compensation-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-compensation-unrecognized-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-compensation-unrecognized-cost-recognition-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-new-shares-sold</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-shares-issued-for-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-shares-issued-value-conversion-of-convertible-securities-net-of-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-shares-issued-value-employee-benefit-plan</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-shares-issued-value-employee-stock-ownership-plan</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-shares-issued-value-stock-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-issued-value-of-shares-issued-for-acquisitions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-options-grants-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-repurchase-program-authorized-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stock-repurchase-program-number-of-shares-authorized-to-be-repurchased</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/stockholders-equity-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-adjustments-settlements-and-unusual-provisions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-credit-carryforward-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-at-federal-statutory-income-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-change-in-deferred-tax-assets-valuation-allowance</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-change-in-enacted-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-deductions-qualified-production-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-foreign-income-tax-rate-differential</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-nondeductible-expense-impairment-losses</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-nondeductible-expense-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-nondeductible-expense-research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-other-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-prior-year-income-taxes</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-tax-contingencies</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-tax-credits-foreign</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-tax-credits-research</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-tax-exempt-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/tax-rate-reconciliation-tax-settlements-foreign</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/taxes-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/total-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/total-contract-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/total-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/total-liabilities-and-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/total-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/treasury-stock-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/treasury-stock-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/unrecognized-tax-benefits</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-decrease-from-acquisition</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-decrease-from-current-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-decrease-from-foreign-currency-translation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-decrease-from-prior-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-decrease-from-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-income-tax-penalties-and-interest-accrued</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-income-tax-penalties-and-interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-increase-from-acquisition</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-increase-from-current-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-increase-from-foreign-currency-translation</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-increase-from-prior-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-reduction-from-statute-lapse</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/utb-that-would-impact-effective-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowance-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowance-deferred-tax-asset-change-in-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowances-and-reserves-balance</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowances-and-reserves-charged-to-cost-and-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowances-and-reserves-deductions</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/valuation-allowances-and-reserves-reserves-of-businesses-acquired</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/value-added-tax-receivable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/shire-plc/weighted-average-number-of-shares-issued-basic</loc></url>
</urlset>
