<?xml version="1.0" encoding="UTF-8"?>
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9">
<url><loc>https://stock.noler.com/us/stock/irwd</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/13f-holdings</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accounts-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accounts-payable-related-parties-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accounts-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accounts-receivable-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accounts-receivable-net-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accretion-amortization-of-discounts-and-premiums-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-bonuses-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-income-taxes-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-payroll-taxes-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-professional-fees-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-salaries-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accrued-vacation-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/accumulated-depreciation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/acquisition-contingent-consideration-arrangements-change-in-amount-of-contingent-consideration-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/acquisition-contingent-consideration-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/acquisition-contingent-consideration-liability-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/acquisition-contingent-consideration-liability-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/activist-13d-13g</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/additional-paid-in-capital-common-stock</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/adjustments-related-to-tax-withholding-for-share-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/allocated-share-based-compensation-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/allocated-share-based-compensation-expense-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/allowance-for-doubtful-accounts-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/amended-reports-10-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/amortization-of-debt-discount-premium</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/amortization-of-financing-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/amortization-of-financing-costs-and-discounts</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/analyst-ratings-buy</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/analyst-ratings-hold</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/analyst-ratings-no-rating</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/analyst-ratings-sell</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/antidilutive-securities-excluded-from-computation-of-earnings-per-share-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/aoci</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/asset-impairment-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/asset-retirement-obligation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/assets-of-disposal-group-including-discontinued-operation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/assets-of-disposal-group-including-discontinued-operation-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/auditor</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-accumulated-gross-unrealized-gain-before-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-accumulated-gross-unrealized-loss-before-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-amortized-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-accumulated-gross-unrealized-loss-before-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-amortized-cost-basis</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-maturities-next-rolling-twelve-months-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-unrealized-loss-position-12-months-or-longer-number-of-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-unrealized-loss-position-less-than-12-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-debt-unrealized-loss-position-less-than-12-months-number-of-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-fair-value-disclosure</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-gross-unrealized-gain</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-gross-unrealized-gains</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-gross-unrealized-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-gross-unrealized-losses</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-in-unrealized-loss-positions-qualitative-disclosure-number-of-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-in-unrealized-loss-positions-qualitative-disclosure-number-of-positions-1</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-in-unrealized-loss-positions-qualitative-disclosure-number-of-positions-greater-than-or-equal-to-one-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-in-unrealized-loss-positions-qualitative-disclosure-number-of-positions-less-than-one-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/available-for-sale-unrealized-loss-position-less-than-twelve-months-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/basic-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/business</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/buyback-authorization</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/buyback-authorization-remaining</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/buybacks-share-repurchases</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/buybacks-shares-repurchased</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/buybacks-shares-repurchased-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-expenditures</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-expenditures-incurred-but-not-yet-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-lease-obligations-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-lease-obligations-incurred</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-lease-obligations-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leased-assets-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-due</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-due-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-due-in-four-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-due-in-three-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-due-in-two-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-interest-included-in-payments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-future-minimum-payments-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/capital-leases-lessee-balance-sheet-assets-by-major-class-accumulated-deprecation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-and-cash-equivalents-change</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-and-equivalents</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-and-restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-and-restricted-cash-change-excluding-exchange-rate-effect</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-equivalents-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-flow-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-provided-by-used-in-financing-activities-discontinued-operations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-provided-by-used-in-investing-activities-discontinued-operations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cash-provided-by-used-in-operating-activities-discontinued-operations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/class-of-warrant-or-right-exercise-price-of-warrants-or-rights</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/clinical-trials</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/common-stock-par-or-stated-value-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/common-stock-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/company-guidance</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/company-profile</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/comprehensive-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/comprehensive-income-net-of-tax-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/comprehensive-income-net-of-tax-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/congressional-trades-stocks-including-adrs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/construction-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/contract-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/convertible-debt-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/convertible-debt-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/convertible-notes-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/convertible-preferred-stock-converted-to-other-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/convertible-securities-retired</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cost-of-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cost-of-revenue-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/costs-and-expenses</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/cover-page-shares-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-federal-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-foreign-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-portion-of-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/current-state-and-local-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-carrying-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-convertible-carrying-amount-of-the-equity-component</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-equity-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-face-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-fee-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-interest-rate-stated-percentage</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-in-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-in-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-in-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-in-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-in-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-maturing-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-repaid</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-unamortized-discount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/debt-weighted-average-interest-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-federal-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-income-tax-assets-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-income-tax-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-income-taxes-and-tax-credits</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-rent-credit-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-rent-credit-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-revenue-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-state-and-local-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-deferred-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-goodwill-and-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-liabilities-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-operating-loss-carryforwards</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-stock-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-tax-credit-carryforwards</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-tax-deferred-expense-reserves-and-accruals</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-assets-valuation-allowance</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-liabilities-goodwill-and-intangible-assets-intangible-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/deferred-tax-liabilities-property-plant-and-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-accumulated-benefit-obligation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-actual-return-on-plan-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-administration-expenses</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-amortization-of-gains-losses</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-amortization-of-prior-service-cost-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-assumptions-used-calculating-benefit-obligation-discount-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-assumptions-used-calculating-net-periodic-benefit-cost-discount-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-assumptions-used-calculating-net-periodic-benefit-cost-expected-long-term-return-on-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-assumptions-used-calculating-net-periodic-benefit-cost-rate-of-compensation-increase</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-benefit-obligation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-benefit-obligation-contributions-by-plan-participant</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-benefit-obligation-increase-decrease-for-remeasurement-due-to-settlement</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-contributions-by-employer</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-curtailments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-expected-future-benefit-payments-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-expected-future-benefit-payments-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-expected-future-benefit-payments-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-expected-future-benefit-payments-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-expected-return-on-plan-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-fair-value-of-plan-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-foreign-currency-exchange-rate-changes-benefit-obligation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-funded-status-of-plan</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-interest-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-net-periodic-benefit-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-plan-amendments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-plan-assets-contributions-by-plan-participant</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-plan-assets-foreign-currency-translation-gain-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-recognized-net-gain-loss-due-to-curtailments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-service-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-benefit-plan-weighted-average-asset-allocations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/defined-contribution-plan-cost-recognized</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/depreciation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/depreciation-and-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/diluted-shares</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/dilutive-securities-effect-on-basic-earnings-per-share-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/discontinued-operation-tax-effect-of-discontinued-operation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/disposal-group-including-discontinued-operation-assets-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/disposal-group-including-discontinued-operation-operating-income-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/disposal-group-including-discontinued-operation-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/dividend</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/dividend-safety</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/dividends-declared</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/due-from-related-parties-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/earnings-per-share-basic-and-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/ebitda</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/ebitda-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/effective-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/employee-count</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/employee-related-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/entity-listing-par-value-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/eps</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/eps-basic</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/exchange-rate-effect-on-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/executive-pay-pvp</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/executive-salary-officers</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/expense-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/fair-value-adjustment-of-warrants</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/fair-value-assets-level-1-to-level-2-transfers-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/fair-value-measurement-with-unobservable-inputs-reconciliations-recurring-basis-liability-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/federal-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/financing-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-amortization-expense-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/finite-lived-intangible-assets-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/foreign-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/foreign-pretax-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/form-144-stocks</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/form-n-port-stocks</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/gain-loss-on-derivative-instruments-net-pretax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/gain-loss-on-sale-of-derivatives</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/gain-loss-on-sale-of-property-plant-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/gains-losses-on-extinguishment-of-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/general-and-administrative-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/goodwill-impairment-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/grants-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/graph</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/gross-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/hedging-assets-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/hedging-assets-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/hedging-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/hedging-liabilities-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/impairment-of-intangible-assets-finitelived</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/impairment-of-intangible-assets-indefinitelived-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/impairment-of-long-lived-assets-held-for-use</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/impairment-of-long-lived-assets-to-be-disposed-of</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/included-in-etf</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax-attributable-to-reporting-entity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax-per-basic-and-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax-per-basic-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-discontinued-operations-net-of-tax-per-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-per-basic-and-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-per-basic-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-loss-from-per-diluted-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-tax-at-federal-statutory-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-tax-examination-penalties-and-interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-tax-paid-foreign-after-refund-received</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-tax-paid-state-and-local-after-refund-received</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-taxes-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/income-taxes-paid-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-accounts-payable-and-accrued-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-accounts-receivable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-contract-with-customer-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-deferred-revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-inventories</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-operating-lease-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-other-current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-other-operating-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-other-operating-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-prepaid-deferred-expense-and-other-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-receivables</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/increase-decrease-in-restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/incremental-common-shares-attributable-to-conversion-of-debt-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/incremental-common-shares-attributable-to-share-based-payment-arrangements</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/insider-transactions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/intangible-assets-net-excluding-goodwill</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-expense-debt-excluding-amortization</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-expense-nonoperating</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-expense-on-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-paid</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-paid-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/interest-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/inventory</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/inventory-finished-goods-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/inventory-raw-materials-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/inventory-work-in-process-net-of-reserves</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/inventory-write-down</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/investing-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/investment-income-interest-and-dividend</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/investment-income-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/iran-activity-notices-irannotice</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/late-filing-notices-nt-10-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/lessee-operating-lease-liability-payments-remainder-of-fiscal-year</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/lessee-operating-lease-liability-undiscounted-excess-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/level-3-asset-gain-loss-included-in-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/level-3-asset-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/level-3-asset-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/level-3-liability-gain-loss-included-in-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/level-3-liability-settlements</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/liabilities-of-disposal-group-including-discontinued-operation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/liabilities-of-disposal-group-including-discontinued-operation-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/litigation-reserve-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/long-term-line-of-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/long-term-notes-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/long-term-purchase-commitment-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/market-cap</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/material-contracts</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/maturities-of-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/minority-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/minority-interest-decrease-from-redemptions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-cash-from</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-cash-from-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-cash-from-investing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-cash-from-operating-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-change-in-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-income-loss-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-income-loss-available-to-common-stockholders-basic</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-income-loss-available-to-common-stockholders-diluted</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/net-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/news</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/non-peo-neo-avg-comp-actually-paid-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/non-peo-neo-avg-total-comp-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/noncash-or-part-noncash-acquisition-fixed-assets-acquired</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/noncash-or-part-noncash-divestiture-amount-of-consideration-received</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/noncontrolling-interest-decrease-from-deconsolidation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/noncontrolling-interest-increase-from-business-combination</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/notes-payable-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/number-of-reportable-segments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-amortization-adjustment-from-aoci-pension-and-other-postretirement-benefit-plans-for-net-prior-service-cost-credit-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-available-for-sale-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-defined-benefit-plan-net-prior-service-costs-credit-arising-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-defined-benefit-plans-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-foreign-currency-transaction-and-translation-adjustment-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-net-of-tax-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/oci-reclassification-adjustment-from-aoci-pension-and-other-postretirement-benefit-plans-for-net-gain-loss-net-of-tax</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-cash-flow</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-expenses</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-liability-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-liability-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-2</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-after-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-future-minimum-sublease-rentals</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-in-five-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-in-four-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-in-three-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-in-two-years</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-next-twelve-months</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-thereafter</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-year-five</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-year-four</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-year-three</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-payments-due-year-two</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-right-of-use-asset-amortization-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-lease-weighted-average-discount-rate-percent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-leases-rent-expense-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-leases-rent-expense-sublease-rentals</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/operating-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/options-activity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-accrued-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-current-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-employee-related-liabilities-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-noncurrent-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-noncurrent-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-nonoperating-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-nonoperating-income-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-than-temporary-impairment-loss-debt-securities-available-for-sale</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/other-than-temporary-impairment-losses-investments-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/outstanding-bonds</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/paid-in-capital-equity-component-of-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/paid-in-capital-equity-component-of-convertible-debt-subsequent-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/paid-in-capital-shares-issued-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/paid-in-capital-stock-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/paid-in-kind-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/patents-active</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payment-for-contingent-consideration-liability-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-for-hedge-financing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-for-hedge-investing-activities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-for-proceeds-from-tenant-allowance</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-for-restructuring</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-of-debt-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-of-derivative-issuance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-to-acquire-available-for-sale-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-to-acquire-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-to-acquire-businesses-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/payments-to-minority-shareholders</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pb-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pe-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/peo-actually-paid-comp-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/peo-total-comp-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pre-tax-margin</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/preferred-shares-facts</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/preferred-stock-par-or-stated-value-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/preferred-stock-shares-authorized</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/preferred-stock-shares-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/preferred-stock-shares-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/prepaid-expense-and-other-assets-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pretax-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pretax-income-domestic</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/pretax-income-minority-interest-and-income-loss-from-equity-method-investments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/previous-etf-holding-it</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/price-fcf-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-and-excess-tax-benefit-from-share-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-divestiture-of-interest-in-consolidated-subsidiaries</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-issuance-initial-public-offering</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-issuance-of-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-issuance-of-preferred-stock-and-preference-stock</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-issuance-of-shares-under-incentive-and-share-based-compensation-plans-including-stock-options</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-issuance-of-warrants</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-long-term-lines-of-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-notes-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-repayments-of-notes-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-sale-and-maturity-of-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-sale-of-available-for-sale-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-sale-of-available-for-sale-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-sale-of-property-plant-and-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-stock-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/proceeds-from-stock-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/production-related-impairments-or-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/profit-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/profit-loss</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/property-plant-and-equipment-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/property-plant-equipment</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/ps-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/public-float</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/purchase-commitment-remaining-minimum-amount-committed</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/purchase-obligation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/quick-ratio</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/related-party-transaction-due-from-to-related-party-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-convertible-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-debt-and-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-long-term-capital-lease-obligations</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-long-term-lines-of-credit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/repayments-of-notes-payable</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/research-and-development</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash-and-cash-equivalents</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash-and-cash-equivalents-at-carrying-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash-and-cash-equivalents-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restricted-cash-noncurrent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-and-related-cost-number-of-positions-eliminated</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-and-related-cost-number-of-positions-eliminated-period-percent</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-charges</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-reserve</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-reserve-accrual-adjustment</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-reserve-current</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-reserve-settled-without-cash</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/restructuring-settlement-and-impairment-provisions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/retained-earnings</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/return-on-tangible-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/revenue</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/revenue-breakdown</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/revenue-from-grants</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/revenue-recognition-milestone-method-revenue-recognized</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/revenues</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/right-of-use-asset-obtained-in-exchange-for-operating-lease-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/roa</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/roe</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/roi</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sales-revenue-goods-net</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/scorecard</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-comment-letters-upload</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-enforcement-actions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-filings-10-q</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-filings-25-nse</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-filings-8-k</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-filings-px14a6g</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sec-filings-s-4</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/secondary-offerings</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/settlement-of-asset-retirement-obligations-through-noncash-payments-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/severance-costs</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sga-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/share-based-goods-and-nonemployee-services-transaction-stockholders-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/shareholders-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/shares-authorized</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/shares-issued</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/shares-outstanding</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/short-sale-volume</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/short-term-lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/state-and-local-income-tax-expense-benefit</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-award-number-of-shares-available-for-grant</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-award-options-exercises-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-award-options-grants-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-award-plan-modification-incremental-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-based-compensation</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-compensation-tax-benefit-from-compensation-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-issued-new-shares-sold</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-issued-shares-issued-for-options-exercised</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-issued-shares-issued-value-conversion-of-convertible-securities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-issued-shares-issued-value-restricted-stock-award-gross</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-issued-value-of-shares-issued-for-stock-awards</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-exercisable-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-exercisable-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-exercisable-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-exercises-in-period-total-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-forfeitures-and-expirations-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-forfeitures-and-expirations-in-period-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-grants-in-period</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-grants-in-period-grant-date-fair-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-outstanding-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-outstanding-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-outstanding-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-vested-and-expected-to-vest-outstanding-aggregate-intrinsic-value</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-vested-and-expected-to-vest-outstanding-average-exercise-price</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-options-vested-and-expected-to-vest-outstanding-number</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-repurchase-program-authorized-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stock-splits</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/stockholders-equity-including-portion-attributable-to-noncontrolling-interest</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/sublease-income</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/subsidiaries</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-credit-carryforward-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-at-federal-statutory-income-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-deductions-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-nondeductible-expense-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-nondeductible-expense-share-based-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-state-and-local-income-taxes</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-rate-reconciliation-tax-contingencies</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-change-in-deferred-tax-assets-valuation-allowance</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-change-in-enacted-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-deductions-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-foreign-income-tax-rate-differential</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-nondeductible-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-nondeductible-expense-other</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-nondeductible-expense-share-based-compensation-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-other-adjustments</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-state-and-local-income-taxes</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-tax-contingencies</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-reconciliation-tax-credits</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/tax-withholding-on-stock-awards</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-assets</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-contract-liability</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-liabilities</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-liabilities-and-equity</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-long-term-debt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/total-shareholder-rtn-amt</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/treasury-stock-acquired-average-cost-per-share</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/unamortized-debt-issuance-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/unrealized-gain-loss-on-derivatives</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/unrecognized-tax-benefits</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-decrease-from-prior-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-income-tax-penalties-and-interest-accrued</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-income-tax-penalties-and-interest-expense</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-increase-from-acquisition</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-increase-from-current-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-increase-from-prior-year-positions</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/utb-that-would-impact-effective-tax-rate</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/valuation-allowance-deferred-tax-asset-change-in-amount</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/variable-lease-cost</loc></url>
<url><loc>https://stock.noler.com/us/stock/irwd/weighted-average-number-of-share-outstanding-basic-and-diluted</loc></url>
</urlset>
